Clonidine
Mostrando 25-36 de 116 artigos, teses e dissertações.
-
25. Participação dos receptores adrenérgicos Alfa2 do núcleo parabraquial lateral no controle da ingestão de sódio.
Water and NaCl intake is strongly inhibited by the activation of α2-adrenergic receptors with clonidine or moxonidine (α2-adrenergic/imidazoline agonists) injected peripherally or into the forebrain and by serotonin and cholecystokinin into the lateral parabrachial nucleus (LPBN), a pontine structure. Serotonergic and cathecolaminergic neurons are
Publicado em: 2006
-
26. Proerectile effect of an alkaloidical rich fraction isolated from aspidosperma ulei markgr.: in vivo and in vitro study. / Efeito pró-erétil de uma fração rica em alcalóides isolada de aspidosperma ulei markgr.: estudo in vivo e in vitro
The genus Aspidosperma (Apocyanaceae) is known to be rich in yohimbine type of indol alkaloids. This study was aimed to evaluate the alkaloid rich fraction (SF3-5) obtained from Aspidiosperma ulei Markgr. root bark for its general toxicity, behavioral effects in mice and a possible proerectile activity. Acute toxicity tests were performed to determine the LD
Publicado em: 2005
-
27. Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both alpha2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nerv
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-10
-
28. EPIDURAL CLONIDINE OR SUFENTANIL IN DOGS UNDERGOING OVARIO-HISTERECTOMY / CLONIDINA OU SUFENTANIL EPIDURAL EM CÃES SUBMETIDOS À OVÁRIO-HISTERECTOMIA
The objective of this study was to evaluate the cardiovascular, respiratory and analgesic effects of epidural clonidine and sufentanil associated with halothane anesthesia and in the immediate postoperative period. In order to study this, twenty female dogs, healthy, among 10 to 20 kg from the routine of Veterinary Hospital of UFSM underwent ovario-histerect
Publicado em: 2004
-
29. Participaçãp do óxido nítrico no efeito sedativo e antinociceptivo dos agonistas a2- adrenérgicos
O mecanismo do efeito sedativo da clonidina (CLO), um agonista α2-adrenérgico não é claro. Como a ativação dos receptores α2-adrenérgicos induz a liberação de Óxido Nítrico (NO) das células endoteliais, testamos a hipótese de que o efeito sedativo e antinociceptivo da CLO sistêmica dependeria de mecanismos relacionados a via NOGMPc. O
Publicado em: 2004
-
30. Protective effects of centrally acting sympathomodulatory drugs on myocardial ischemia induced by sympathetic overactivity in rabbits
It is recognized that an imbalance of the autonomic nervous system is involved in the genesis of ventricular arrhythmia and sudden death during myocardial ischemia. In the present study we investigated the effects of clonidine and rilmenidine, two centrally acting sympathomodulatory drugs, on an experimental model of centrally induced sympathetic hyperactivi
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-01
-
31. Efeitos da injeção de moxonidina no controle da ingestão de sódio e regulação cardiovascular.
Deficit of water and sodium in the body is detected by receptors located in different parts of the body. These receptors or hormones signalize to specific areas in the brain that control renal responses and water and sodium intake. Among these areas are: organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), anteroventral third ventricl
Publicado em: 2003
-
32. Adrenoceptors of the medial septal area modulate water intake and renal excretory function induced by central administration of angiotensin II
We investigated the role of a-adrenergic antagonists and clonidine injected into the medial septal area (MSA) on water intake and the decrease in Na+, K+ and urine elicited by ANGII injection into the third ventricle (3rdV). Male Holtzman rats with stainless steel cannulas implanted into the 3rdV and MSA were used. ANGII (12 nmol/µl) increased water intake
Braz J Med Biol Res. Publicado em: 2002-08
-
33. Clonidine p-isothiocyanate, an affinity label for alpha 2-adrenergic receptors on human platelets.
Exposure of intact human platelets or platelet membranes to the clonidine analog clonidine p-isothiocyanate (clonidine-NCS), followed by extensive washing, results in the loss of [3H]yohimbine binding to platelet alpha 2-receptors. In addition, exposure of intact platelets to clonidine-NCS, followed by extensive washing, results in the loss of of epinephrine
-
34. Acetylcholine receptor channels and their block by clonidine in cultured bovine chromaffin cells.
1. Acetylcholine (10-50 microM) applied to bovine chromaffin cells under whole-cell voltage clamp produced an inward current and an increase in the noise level of the current trace. At concentrations greater than or equal to 20 microM the ACh current desensitized with time. Spectral analysis of the ACh-induced increase in current noise showed that it could b
-
35. Roberts's syndrome and clonidine.
A child is described with features of Robert's syndrome. The mother took clonidine during pregnancy. The question of a relationship between the child's abnormalities and clonidine is raised.
-
36. Cardiovascular responses to static exercise in conscious cats: effects of intracerebroventricular injection of clonidine.
1. Static exercise elicits increases in arterial blood pressure and heart rate (HR) in humans and conscious animals. In this study, the effects of intracerebroventricular (I.C.V.) administration of clonidine, an alpha 2-adrenergic agonist, on these cardiovascular responses were investigated using conscious cats. Four cats were operantly trained to extend a f