Clofazimine
Mostrando 1-12 de 65 artigos, teses e dissertações.
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1. Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): adverse effects approach
Abstract: BACKGROUND: The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE: Describe adverse effects due to MDT in U-MDT/CT-BR, comparing the uniform regimen (U-MDT) to the current WHO regimen
An. Bras. Dermatol.. Publicado em: 2018-06
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2. Lobomycosis: a therapeutic challenge
Abstract: Lobomycosis or lacaziosis is a chronic granulomatous fungal infection caused by Lacazia loboi. Most cases are restricted to tropical regions. Transmission is believed to occur through traumatic inoculation in the skin, mainly in exposed areas. It is characterized by keloid-like nodules. There are only a few hundred cases reported. The differential
An. Bras. Dermatol.. Publicado em: 2018-03
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3. Ashy dermatosis with involvement of mucous membranes
Abstract: Ashy dermatosis is a rare condition, of unknown aetiology, in which mucous membranes are typically spared. The authors report the case of a 57-year-old female with a history of asymptomatic gray-bluish macules located on the trunk and oral mucosa. There were no relief changes on examination. Skin biopsies from the oral mucosa and trunk were perform
An. Bras. Dermatol.. Publicado em: 2017
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4. A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
The resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB drugs was analysed. A total of 73 isolates were susceptible and 66 were resistant to anti-TB drugs. Monoresistance to streptomycin, isoniazid (INH) and ethambutol was observed in 29 cases. Resistance to INH was found
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-04
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5. Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects
This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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6. WBC count and functional changes induced by co-administration of clofazimine and clarithromycin, in single and multiple doses, in Wistar rats
Clofazimina e laritromicina são utilizadas no tratamento da hanseníase e em infecções causadas pelo complexo Mycobacterium avium. Devido à escassez de dados sobre a toxicidade de esquemas terapêuticos que associam estes fármacos, este estudo teve por objetivo avaliar os efeitos adversos desta terapia, em ratos machos Wistar, por meio da determinação
Braz. J. Pharm. Sci.. Publicado em: 2012-09
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7. Use of the polymerase chain reaction to detect Mycobacterium leprae in urine
Leprosy is an infectious disease caused by Mycobacterium leprae. The polymerase chain reaction (PCR) has been applied to detect M. leprae in different clinical samples and urine seems to be attractive for this purpose. PCR was used to improve the sensitivity for diagnosing leprosy by amplifying a 151-bp PCR fragment of the M. leprae pra gene (PCR-Pra) in uri
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-02
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8. Queilite granulomatosa associada à síndrome de Melkersson-Rosenthal
A síndrome de Melkerson-Rosenthal (SMR) caracteriza-se por edema orofacial, paralisia facial recorrente e língua plicada. A tríade completa é incomum, com freqüência variando de 8 a 25%, sendo que a apresentação mais comum é a presença de somente um sintoma. A queixa mais freqüente é o edema facial e/ou no lábio. No presente relato, descreve-se
Revista Brasileira de Otorrinolaringologia. Publicado em: 2007-02
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9. Hematological and hemostatic alterations induced by clofazimine and clarithromycin in rats / Alterações hematológicas e hemostáticas induzidas pela clofazimina e claritromicina em ratos
Clarithromycin and clofazimine have been used to treat leprosy and tuberculosis as well as infections of Mycobacterium avium complex, an ordinary complication in patients who are in advanced stage of Acquired Immunodeficiency Syndrome (AIDS). As the data about the toxicity of therapeutic schemes including those drugs are scarce, this research had the aim to
Publicado em: 2007
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10. Ensaio clínico duplo-cego controlado e randômico, comparando a eficácia da Clofazimina com a Cloroquina, no tratamento das lesões cutâneas do Lúpus Eritematoso Sistêmico
PURPOSE: To evaluate the capacity of clofazimine (CFZ) to control cutaneous activity of systemic lupus erythematosus (SLE), compared with chloroquine diphosphate (CDP). METHODS: A prospective, randomized, controlled, double blind clinical trial was carried out in thirty-three patients with SLE and cutaneous lesions (malar rash and/or discoid lupus and/or sub
Publicado em: 2007
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11. A therapeutic study comparing the association of rifampin, ofloxacin and minocycline with the association of rifampin, clofazimine and dapsone in multibacillary leprosy patients
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2007
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12. Perfil laboratorial bioquÃmico e hematolÃgico de uma populaÃÃo de pacientes diagnosticados com hansenÃase: antes e durante a poliquimioterapia
Leprosy or Hansenâs disease is an infectious disease with slow flow velocity, transmitted by Mycobacterium leprae that attacks nerves and skin. The specific treatment for people who suffer of leprosy was emphasized in the beginning of the 80âs by the World Health Organization (WHO) in order to cure the infection with Mycobacterium leprae and prevent disabi
Publicado em: 2007