Clinical Expression Of Asthma
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Increased expression of pendrin in eosinophilic chronic rhinosinusitis with nasal polyps
Resumo Introdução: A rinossinusite crônica com pólipos nasais é uma doença heterogênea e algoritmos diagnósticos apropriados em casos individuais são necessários para um tratamento médico eficaz. Objetivo: O objetivo deste estudo foi esclarecer a relação entre a expressão da pendrina de pólipos nasais e propriedades clínicas e patológicas
Braz. j. otorhinolaryngol.. Publicado em: 13/12/2019
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2. Increased immunohistochemical expression of YKL-40 in the spleen of patients with portal hypertension
YKL-40 has been identified as a growth factor in connective tissue cells and also a migration factor in vascular smooth muscle cells. To a large extent, the increase of serum YKL-40 is attributed to liver fibrosis and asthma. However, the relationship of the expression and clinical/prognostic significance of YKL-40 to the splenomegaly of patients with portal
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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3. Prevalência de sibilância em lactentes nas unidades básicas de saúde do município de Belo Horizonte-MG
The prevalence of recurrent wheezing in early childhood greatly varies in world-wide population. It may be the clinical expression of many lung diseases or not, being asthma one of them, so it is a clinical syndrome. The great variation in prevalence is related to different definitions, study designs and considered age groups. Its evaluation poses a big chal
Publicado em: 2009
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4. A INFLUÊNCIA DO STRESS NA EXPRESSÃO CLÍNICA DA ASMA INFANTIL
Asthma is the most frequent chronic disease in childhood and stress is considered one of the triggering and aggravating agents of bronchospasm in this patients. The aim of this work was investigate the influence of stress in the clinical expression of asthma and your association with the asthma attacks in children. The asthmatic children answered to a stress
Publicado em: 2004
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5. Asthma Therapies Revisited: What Have We Learned?
Asthma is a heterogenous disorder related to numerous biologic, immunologic, and physiologic components that generate multiple clinical phenotypes. Further, genetic and environmental factors interact in ways that produce variability in both disease onset and severity and differential expression based on both the age and sex of the patient. Thus, the natural
American Thoracic Society.
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6. Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil transmigration across endothelium, mucus secretion, and differentiation of T helper type 2 lymphocytes leading to cytokine release. Asthma is a complex ge
BioMed Central.
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7. Interleukin 9: A candidate gene for asthma
Asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of atopy and bronchial hyperresponsiveness. Recent studies localized a major gene for asthma to chromosome 5q31-q33 in humans. Thus, this segment of the genome represents a candidate region for genes that determine susceptibility to bronchial hyperresponsiveness
The National Academy of Sciences of the USA.
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8. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease
The Runx3 transcription factor is a key regulator of lineage-specific gene expression in several developmental pathways and could also be involved in autoimmunity. We report that, in dendritic cells (DC), Runx3 regulates TGFβ-mediated transcriptional attenuation of the chemokine receptor CCR7. When Runx3 is lost, i.e., in Runx3 knockout mice, expression of
National Academy of Sciences.
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9. Effect of natural allergen exposure during the grass pollen season on airways inflammatory cells and asthma symptoms.
BACKGROUND: Bronchial challenge with allergen causes a specific form of airways inflammation consisting of an influx of neutrophils, eosinophils, and T cells. Because the relevance of the challenge model to clinical asthma is uncertain, the cellular changes that occur in the lungs of asthmatic subjects during natural seasonal allergen exposure were investiga
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10. TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids
TBX21 encodes for the transcription factor T-bet (T-box expressed in T cells), which influences naïve T lymphocyte development and has been implicated in asthma pathogenesis. Specifically, the T-bet knockout mouse spontaneously develops airway hyperresponsiveness and other changes consistent with asthma. Because airway responsiveness is moderated by the use
National Academy of Sciences.
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11. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients
Gene expression profiles were examined in freshly isolated peripheral blood mononuclear cells (PBMC) from two independent cohorts (training and test sets) of glucocorticoid (GC)-sensitive (n = 64) and GC-resistant (n = 42) asthma patients in search of genes that accurately predict responders and nonresponders to inhaled corticosteroids. A total of 11,812 gen
National Academy of Sciences.
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12. Respiratory Syncytial Virus Infection and G and/or SH Protein Expression Contribute to Substance P, Which Mediates Inflammation and Enhanced Pulmonary Disease in BALB/c Mice
A distinct clinical presentation of respiratory syncytial virus (RSV) infection of humans is bronchiolitis, which has clinical features similar to those of asthma. Substance P (SP), a tachykinin neuropeptide, has been associated with neurogenic inflammation and asthma; therefore, we chose to examine SP-induced inflammation with RSV infection. In this study,
American Society for Microbiology.