Claudins
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. A expressão das claudinas 1, 3, 4, 7 e E-caderina em uma série de tumores de mama triplo-negativos
INTRODUCTION: Breast cancer is a major cause of morbidity and mortality, is known to be a heterogeneous disease. The clinical and molecular characterization of its subtypes is critical to guide the prognosis and treatment of these patients. Further studies are needed for the best characterization of triple-negative tumors. The study of the expression of clau
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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2. Estudo da expressão das proteínas juncionais e dos fatores inflamatórios em pacientes com doença do refluxo gastroesofágico erosiva e não erosiva / Study of expressions of junctionals proteins and inflammatory factors in patients with gastro-oesophageal reflux disease and non-erosive reflux disease
Pacientes com doença do refluxo não erosiva apresentam sintomas típicos causados pelo refluxo do conteúdo gástrico para o esôfago. Entretanto, estes pacientes não apresentam alterações de mucosa visualizadas à endoscopia. O objetivo deste estudo é caracterizar a expressão de moléculas relacionadas à junção celular (claudinas 1, 3 e 4), da pro
Publicado em: 2009
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3. Imunoexpressão das claudinas -1 e -7 em ameloblastomas e germes dentais humanos
Investigamos a expressão imuno-histoquímica das claudinas -1 e -7 em ameloblastomas e germes dentais humanos, avaliando o padrão de distribuição (focal, regional ou difuso), as células que as expressavam (central ou periférica) e a localização dessa expressão nos constituintes celulares considerando membrana, citoplasma e núcleo. Dentre os 29 caso
Publicado em: 2008
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4. The claudins
Claudins are crucial components of tight junctions and are important in regulating permeability and maintaining cell polarity in cell sheets.
BioMed Central.
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5. Expression and phylogeny of claudins in vertebrate primordia
Claudins, the major transmembrane proteins of tight junctions, are members of the tetraspanin superfamily of proteins that mediate cellular adhesion and migration. Their functional importance is demonstrated by mutations in claudin genes that eliminate tight junctions in myelin and the testis, abolish Mg2+ resorption in the kidney, and cause autosomal recess
The National Academy of Sciences.
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6. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins
Mutations in the WNK4 gene cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder of hyperkalemia and hypertension. The target molecules of this putative kinase and the molecular mechanisms by which the mutations cause the phenotypes are currently unknown. Although recent reports found that expression of WNK4 in Xenopus oocytes causes
National Academy of Sciences.
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7. Tight junctions, but not too tight: fine control of lung permeability by claudins
American Physiological Society.
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8. Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins
BioMed Central.
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9. Molecular Determinants of the Interaction between Clostridium perfringens Enterotoxin Fragments and Claudin-3
Clostridium perfringens enterotoxin (CPE) binds to the extracellular loop 2 of a subset of claudins, e.g. claudin-3. Here, the molecular mechanism of the CPE-claudin interaction was analyzed. Using peptide arrays, recombinant CPE-(116–319) bound to loop 2 peptides of mouse claudin-3, -6, -7, -9, and -14 but not of 1, 2, 4, 5, 8, 10–13, 15, 16, 18–20, a
American Society for Biochemistry and Molecular Biology.
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10. Extensive Expansion of the Claudin Gene Family in the Teleost Fish, Fugu rubripes
In humans, the claudin superfamily consists of 19 homologous proteins that commonly localize to tight junctions of epithelial and endothelial cells. Besides being structural tight-junction components, claudins participate in cell–cell adhesion and the paracellular transport of solutes. Here, we identify and annotate the claudin genes in the whole-genome of
Cold Spring Harbor Laboratory Press.
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11. Tight Junction Proteins in Human Schwann Cell Autotypic Junctions
Tight junctions (TJs) form physical barriers in various tissues and regulate paracellular transport of ions, water, and molecules. Myelinating Schwann cells form highly organized structures, including compact myelin, nodes of Ranvier, paranodal regions, Schmidt-Lanterman incisures, periaxonal cytoplasmic collars, and mesaxons. Autotypic TJs are formed in non
Histochemical Society.
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12. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
Two related integral membrane proteins, claudin-1 and -2, recently were identified as novel components of tight junction (TJ) strands. Here, we report six more claudin-like proteins, indicating the existence of a claudin gene family. Three of these were reported previously as RVP1, Clostridium perfringens enterotoxin receptor, and TMVCF, but their physiologi
The National Academy of Sciences.