Ciliary Neurotrophic Factor
Mostrando 1-12 de 65 artigos, teses e dissertações.
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1. Investigação da ação neuroprotetora do fator neurotrofico ciliar (CNTF) conjugado com peptideo contendo dominio de translocação de proteina (PTD) / Investigation of neuroprotective action of ciliary neurotrophic factor (CNTF) fused to a protein transduction domain (PTD)
Ciliary neurotrophic factor (CNTF) is known as a neuroprotective agent on motoneurons after peripheral nerve section in neonatal rats and adult mice. However, side effects like weight loss and caquexia have limited its clinical use. A promising approach for the avoidance of such side effects is the fusion of a protein transduction domain (PTD) with CNTF. Pre
Publicado em: 2009
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2. Ciliary Neurotrophic Factor (CNTF) effects over pancreatic islets function and survival / Efeitos do Ciliary Neurotrophic Factor (CNTF) sobre a função e sobrevivencia de ilhotas pancreaticas
Introduction: CNTF belongs to the IL-6 cytokine family and as such, it signals through gp130 receptor complex, activating many pathways depending on the cell-type, mainly STAT3, MAPK and PI3K. Its effects include increased neuron differentiation and/or survival, and are differentially expressed throughout the animal life. Meanwhile, pancreatic islets are ric
Publicado em: 2009
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3. Effects of systemic administration of ciliary neurotrophic factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection
Ciliary neurotrophic factor (CNTF) is a cytokine that plays a neuroprotective role in relation to axotomized motoneurons. We determined the effect of daily subcutaneous doses of CNTF (1.2 µg/g for 5 days; N = 13) or PBS (N = 13) on the levels of mRNA for Bcl-2 and Bax, as well as the expression and inter-association of Bcl-2 and Bax proteins, and the surviv
Brazilian Journal of Medical and Biological Research. Publicado em: 31/10/2008
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4. Functional properties of the protein transduction domais associated ciliary neurotrophic factor : analysis of its effects on energy metabolism regulating hypothalamic regions / Propriedades funcionais do fator neurotrofico ciliar associado a um dominio de translocação de proteina : analise de seus efeitos sobre regioes hipotalamicas reguladoras do metabolismo energetico
O Fator Neurotrófico Ciliar (CNTF) é uma neurocitocina com múltiplas atividades biológicas, sendo notável sua habilidade de proteger motoneurônios. Entretanto, a administração de CNTF leva à redução de peso corporal. Por outro lado, a administração do CNTF fusionado a um Domínio de Transdução de Proteínas (PTD), denominado TAT-CNTF, é capaz
Publicado em: 2007
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5. Ações das Neurocinas CNTF e IL-6 Exógenas na Regeneração Nervosa Periférica / Effects of Exogenous Ciliary Neurotrophic Factor and lnterleukin-6 in Peripheral Nerve Regeneration
Foi estudada a ação do fator neurotrófico ciliar (CNTF) e da interleucina 6 (IL-6) exógenos na regeneração nervosa periférica. Aplicação de CNTF recombinante humano: o nervo ciático de 12 camundongos adultos C57BL/6J (3 grupos, n=4) foi seccionado e os cotos proximal e distal ancorados com ponto único de sutura no interior de tubo de polietileno (
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/01/1999
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6. Apoptose de neuronios motores, interneuronios e neuronios sensitivos induzida pela transecção do nervo ciatico em ratos recem nascidos : padrão temporal e efeitos do tratamento com fatores neurotroficos (NGH e CNTF)
Transection of a peripheral nerve in neonatal rats induces an extensive death of axotomized neurons. We demonstrate here that spinal motoneurons and sensory dorsal root ganglia neurons become TUNEL-labeled (tenninal deoxynuc1eotidyl transferase dUTP nick end labelling) afier sciatic nerve transection in neonatal rats, thus indicating that apoptotic mechanism
Publicado em: 1999
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7. Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease.
Huntington disease is a dominantly inherited, untreatable neurological disorder featuring a progressive loss of striatal output neurons that results in dyskinesia, cognitive decline, and, ultimately, death. Neurotrophic factors have recently been shown to be protective in several animal models of neurodegenerative disease, raising the possibility that such s
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8. Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.
Embryonic and neonatal neurons require specific trophic supplements for their survival and the induction of transmitter-synthesizing enzymes in vivo and in vitro. Acidic and basic fibroblast growth factor (aFGF, bFGF) and the closely related astroglial growth factors AGF-1 and AGF-2 were studied for putative neurotrophic functions using dissociated, highly n
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9. Neurotrophic factor intervention restores auditory function in deafened animals
A primary cause of deafness is damage of receptor cells in the inner ear. Clinically, it has been demonstrated that effective functionality can be provided by electrical stimulation of the auditory nerve, thus bypassing damaged receptor cells. However, subsequent to sensory cell loss there is a secondary degeneration of the afferent nerve fibers, resulting i
The National Academy of Sciences.
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10. A Trypanosomal Protein Synergizes with the Cytokines Ciliary Neurotrophic Factor and Leukemia Inhibitory Factor to Prevent Apoptosis of Neuronal Cells
Despite the neuronal degeneration in the chronic stage of Chagas' disease, neuron counts actually increase in the preceding, asymptomatic stage, in contrast to the age-related decrease in neuron counts in age-matched normal individuals. Relevant to this observation, we found that the trans-sialidase (TS) of Trypanosoma cruzi, the etiologic agent of Chagas' d
The American Society for Cell Biology.
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11. Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo.
We have investigated the neuroprotective effects of recombinant human ciliary neurotrophic factor (CNTF) for injured dopaminergic neurons of the adult rat substantia nigra compacta. Fourteen days after a unilateral transection of the nigrostriatal pathway two-thirds of the neurons (identified by retrograde labeling) had degenerated. In sharp contrast, 73% (a
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12. The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor α Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription PathwayD⃞
Cytokines regulate numerous cell processes, including connexin expression and gap junctional coupling. In this study, we examined the effect of ciliary neurotrophic factor (CNTF) on connexin43 (Cx43) expression and intercellular coupling in astrocytes. Murine cortical astrocytes matured in vitro were treated with CNTF (20 ng/ml), soluble ciliary neurotrophic
The American Society for Cell Biology.