Ciliary Neorotrophic Factor
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1. Investigação da ação neuroprotetora do fator neurotrofico ciliar (CNTF) conjugado com peptideo contendo dominio de translocação de proteina (PTD) / Investigation of neuroprotective action of ciliary neurotrophic factor (CNTF) fused to a protein transduction domain (PTD)
Ciliary neurotrophic factor (CNTF) is known as a neuroprotective agent on motoneurons after peripheral nerve section in neonatal rats and adult mice. However, side effects like weight loss and caquexia have limited its clinical use. A promising approach for the avoidance of such side effects is the fusion of a protein transduction domain (PTD) with CNTF. Pre
Publicado em: 2009