1. Neuroproteção dopaminérgica pela associação de exercício físico espontâneo e tratamento crônico com nicotina no modelo da doença de Parkinson em ratos - indicativos dos mecanismos envolvidos / Dopaminergic neuroprotection through the association of spontaneous physical exercise and chronic treatment with nicotine in a rat model of Parkinsons disease indicative of involved mechanisms.

A doença de Parkinson é uma patologia neurodegenerativa progressiva, que acomete mais de 1% da população acima de 60 anos, caracterizada pela morte de neurônios dopaminérgicos do sistema nigroestriatal. O tratamento atualmente disponível não fornece a cura para a doença de Parkinson. Contudo, a abordagem interdisciplinar tem sido capaz de melhorar a

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/03/2011

2. Nicotine effects on LPS-induced NF-capaB in the central nervous system / Efeito da nicotina na ativação do fator de transcrição NF-B no sistema nervoso central na vigência de estímulo inflamatório induzido por lipopolissacarídeo (LPS)

Nicotine is an alkaloid extracted from Tobacco plants, and it acts as an agonist in neurons and other cells that express nicotinic receptors. This substance crosses the blood brain barrier and mimics endogenous acetylcholine in interacting with various receptor subtypes. The hippocampus and cerebellum are brain regions rich in nicotinic receptors including 7

Publicado em: 2009

3. "Efeito modulatório da nicotina sobre a neurotransmissão em núcleos encefálicos responsáveis pelo controle cardiovascular em ratos geneticamente hipertensos e normotensos" / "Nicotine modulatory effects on neurotransmiter systems in the cardiovascular brain areas of spontaneously hypertensive and normotensive rats"

Nicotine is one of the most important agents for cardiovascular diseases in tobacco smoking. This alkaloid acts in the blood stream, but it also crosses the blood-brain-barrier and participate in the regulation of pivotal neurotransmitter systems for the blood pressure control and, eventually, for hypertension development. In this context, nicotine abuse cou

Publicado em: 2006

4. Avaliação dos fatores de risco para o abcesso mamario subareolar recorrentecom fistula

The recurrent subareolar breast abscess with fistulae is a non lactational mastitis, characteristically chronic and recurrent, that during its evolution develops a skin fistulae in the periareolar region. Usually affect young women and have as consequence anatomic a!terations due to local fibrosis and scars. Among the several risk factors to the occurrence o

Publicado em: 1995

5. Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal

Elevation of the neuropeptide corticotropin-releasing factor (CRF) in the brain is associated with a reduction of food intake and body weight gain in normal and obese animals. A protein that binds CRF and the related peptide, urocortin, with high affinity, CRF-binding protein (CRF-BP), may play a role in energy homeostasis by inactivating members of thi

The National Academy of Sciences of the USA.