Chronic Allergic Inflammation
Mostrando 1-12 de 52 artigos, teses e dissertações.
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1. Ability of two new thiazolidinediones to downregulate proinflammatory cytokines in peripheral blood mononuclear cells from children with asthma
Allergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, particularly that involving peroxisome proliferator-activated receptors (PPARs). In response, two new thiazolidi
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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2. Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1/Th2/Th17 cytokine balance in neonatal asthmatic mice
Asthma is a chronic allergic disease characterized by airway inflammation, airway hyper-responsiveness (AHR), and mucus hypersecretion. T-lymphocytes are involved in the pathogenesis of asthma, mediating airway inflammatory reactions by secreting cytokines. The phosphoinositide 3-kinase (PI3K) and Notch signaling pathways are associated with T cell signaling
Braz J Med Biol Res. Publicado em: 20/07/2017
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3. Granulocyte-Macrophage Colony-Stimulating Factor Production and Tissue Eosinophilia in Chronic Rhinitis
Abstract Introduction Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a strong proinflammatory cytokine that takes part in allergic nasal inflammation as an eosinophil colony-stimulating factor. However, the role of GM-CSF in non-allergic rhinitis has not been fully explored. Objectives The aim of this investigation was to assess the concent
Int. Arch. Otorhinolaryngol.. Publicado em: 2016-12
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4. Tratamento com inibidor da Rho quinase em cobais com inflamação pulmonar alérgica crônica: modulação da inflamação eosinofílica, da expressão de citocinas inflamatórias, da matriz extracelular e do estresse oxidativo no parênquima pulmonar / Treatment with Rho-kinase inhibitor in guinea pigs with chronic allergic inflammation: modulation of eosinophilic inflammation, expression of inflammatory cytokines, extracellular matrix and oxidative stress in lung tissue
RATIONALE: Previous studies with Rho-kinase inhibitors suggest a beneficial influence of these drugs in asthma. The relevance of distal lung tissue in functional asthmatic impairment has been intensely emphasized. There have not been any previous studies evaluating the effects of these inhibitors on the modulation of distal lung mechanics and histopathologic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2012
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5. Estudo da ativação eosinofílica e de matriz extracelular de tecido pulmonar periférico em cobaias com inflamação alérgica pulmonar: efeitos do tratamento com dexametasona e antagonista do receptor do cisteinil-leucotrieno D4
Aims: Compare the effects of montelukast or dexamethasone treatments on eosinophilic recruitment, eotaxin, RANTES, fibronectin, IGF-I and NF-B positive cells of distal lung parenchyma and also in airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods: GP were inhaled with ovalbumin (OVA group-2x/week/4weeks). After 4th inhalation, GP we
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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6. Evaluation of lung function and histopathology in an experimental model of chronic allergic pulmonary inflammation: effects of reduced cholinergic function in genetically modified mice / Avaliação da função e da histopatologia pulmonar em modelo experimental de inflamação pulmonar alérgica crônica: efeitos da redução da função colinérgica em camundongos geneticamente modificados
INTRODUÇÃO: A Asma Brônquica é caracterizada por obstrução ao fluxo aéreo, reversível ou não, e processo inflamatório pulmonar, caracterizado principalmente por eosinofilia. A persistência da inflamação pode induzir processo de reparo pulmonar associado à redução progressiva da função pulmonar. A recente descrição do sistema colinérgico
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/06/2012
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7. Tratamento com inibidor da Rho quinase em cobaias com inflamação alérgica crônica: modulação da inflamação eosinofílica, da expressão de citocinas inflamatórias, da matriz extracelular, do estresse oxidativo e da reatividade de vias aéreas / Treatment with Rho-kinase inhibitor in guinea pigs with chronic allergic inflammation: modulation of eosinophilic inflammation, expression of inflammatory cytokines, extracellular matrix, oxidative stress and airway responsiveness
INTRODUÇÃO: Vários estudos têm mostrado a importância da Rho quinase na modulação da contração do músculo liso, hiperresponsividade das vias aéreas e inflamação. Entretanto, os efeitos do tratamento crônico com um inibidor específico desta via não haviam sido previamente investigados. MÉTODOS: No presente estudo, foram avaliados os efeitos d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/04/2012
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8. Efeitos dos tratamentos com glicocorticóides, com antagonista do receptor do cisteinil-leucotrieno D4 e com o inibidor específico da iNOS na resposta inflamatória e de remodelamento no tecido pulmonar periférico em mode / Efects of treatment with glucocorticoids, associated with cisteinil-leukotriene D4 antagonist and specific iNOS inhibitor in inflammatory response and remodeling in pulmonary tissue of chronic pulmonary inflammation model
Introdução: Estima-se que 10% dos doentes com asma tm sintomas e limitaes importantes, como exacerbaes freqentes ou reduo persistente da funo respirat ria As alteraes do parnquima pulmonar distal tem sido recentemente abordadas na fisiopatologia da asma. Apesar do uso de corticoster ides, pacientes com asma refratria tm mais
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2012
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9. Inactivation of capsaicin-sensitive nerves reduces pulmonary remodeling in guinea pigs with chronic allergic pulmonary inflammation
Pulmonary remodeling is an important feature of asthma physiopathology that can contribute to irreversible changes in lung function. Although neurokinins influence lung inflammation, their exact role in the extracellular matrix (ECM) remodeling remains to be determined. Our objective was to investigate whether inactivation of capsaicin-sensitive nerves modul
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-02
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10. Influence of the female sexual hormones about the pulmonary allergic inflammation in model murino of chronic asthma. / Influência dos hormônios sexuais femininos sobre a inflamação alérgica pulmonar em modelo murino de asma crônica.
We evaluated the influence of female sex hormones on the pulmonary alergic asthma in a experimental chronic asthma model.Groups: Basal, (non-manipulated animals), Ovx (Ovariectomized) and Sham- Ovx/ allergic ( animals subjected to similar manipulations except for the ovaries removal) sensitized 7 days after ovarietcomy and challenged with OVA after the 21st
Publicado em: 2010
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11. Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation
We evaluated the effects of chronic allergic airway inflammation and of treadmill training (12 weeks) of low and moderate intensity on muscle fiber cross-sectional area and mRNA levels of atrogin-1 and MuRF1 in the mouse tibialis anterior muscle. Six 4-month-old male BALB/c mice (28.5 ± 0.8 g) per group were examined: 1) control, non-sensitized and non-trai
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-04
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12. Efeitos do treinamento físico aeróbico de baixa intensidade na inflamação alérgica crônica e na resposta imune de camundongos sensibilizados / Effects of the aerobic physical training of decrease intensity in the chronic allergic inflammation and in the immune response of mice sensitized
The physical training (PT) is part of the pulmonary rehabilitation of asthmatic patients and seems to reduce the number of crises, the use of medicine, the broncoespasm prompted by the exercise and increase the tolerance to the effort and the quality of life. Despite of these benefits, a few studies have investigated possible anti-inflammatory effects trigge
Publicado em: 2009