Chiral Auxiliaries
Mostrando 1-4 de 4 artigos, teses e dissertações.
-
1. Synthetic Studies toward (−)-Cleistenolide: Highly Stereoselective Synthesis of New γ-Lactone Subunits
This study describes the stereoselective synthesis of two new γ-lactones in 6 and 3 steps and 19 and 32% yield, respectively, directed toward the total synthesis of the natural product (−)-cleistenolide. The starting material was an enantiomerically pure diacetonide diol, derived from d-mannitol with the required stereocenters for (−)-cleistenolide synt
J. Braz. Chem. Soc.. Publicado em: 2021-04
-
2. Síntese de aminoálcoois derivados do D-manitol
Aminoalcohols have found important applications in synthetic and medicinal chemistry, being used as chiral building blocks for the synthesis of many biologically active compounds. This class of compounds has been also used as chiral auxiliaries and ligands in asymmetric synthesis. Due to the importance of aminoalcohols in the treatment of several diseases, s
Química Nova. Publicado em: 2008
-
3. Adição de nucleofilos a ions N-aciliminios quirais e reações de ciclização promovidas por Pd(0) / Nucleophilic addition to chiral N-acyliminium ions and palladium(0)-mediated cyclization reactions
The first part of this work described the addition of carbon nucleophiles to chiral N-acyliminium ions derived from tetrahydroisoquinoline. Once established for the racemic series, the methodology was explored with chiral N-acyliminium ions derived from (1R,2S)-(-)-trans-phenylcyclohexanol (97) and (1R,2S,5R)-(-)-8-phenylmenthol (98). The addition of allyltr
Publicado em: 2006
-
4. The addition of allyltrimethylsilane to cyclic N-acyliminium ions derived from(S)-(+)-mandelic acid and cyclohexyl-based chiral auxiliaries
A adição de aliltrimetilsilano, promovida por TiCl4, a íons N-aciliminios cíclicos de 5- e 6-membros derivados do ácido (S)-(+)-mandélico, (1R,2S)-trans-2-fenil-1-cicloexanol e (1R,2S,5R)-8-fenilmentol ocorreu com baixas a moderadas razões diastereoisoméricas (1:1-6:1) e forneceu as respectivas amidas e carbamatos em bons rendimentos. A melhor diaste
Journal of the Brazilian Chemical Society. Publicado em: 2001-08