Mostrando 1-12 de 55 artigos, teses e dissertações.
1. Avaliação funcional dos eosinófilos na anemia falciforme e o efeito do tratamento com hidroxiureia / Altered functional properties of eosinophils in sickle cell anemia and effects of hydroxyurea therapy
Sickle cell anemia is the homozygous state for hemoglobin S. Inflammation plays an important role in the vaso-occlusive process of the disease, where leukocytes, proinflammatory cytokines and adhesion molecules are increased in the peripheral blood of patients with sickle cell anemia. Leukocytosis is associated with morbidity and mortality in these patients.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2011
2. Modulação de eventos da imunidade humoral e celular por venenos brutos e componentes dos venenos de Bothrops jararacussu e Bothrops pirajai / Modulation of events of humoral and cellular immunity by crude venom and components of Bothrops jararacussu and Bothrops pirajai
Snakes of the genus Bothrops are responsible for 90% of snakebites in Brazil. Their venoms cause local effects in humans and animals, such as hemorrhage, edema, pain and necrosis, characteristic of an inflammatory response. The mechanism is not well defined. These effects are related to the combined action of proteases, substances that induce bleeding and ph
Publicado em: 2010
3. Studies on the leukocyte component and chemotactic mediators of the inflammatory reaction induced by Bothrops moojeni venom. Participation of mast cells and histamine in leukocyte recruitment. / Estudo do componente leucocitário e de mediadores quimiotáticos da reação inflamatória induzida pelo veneno de Bothrops moojeni. Participação de mastócitos e da histamina no recrutamento leucocitário
In this study the effects of Bothrops moojeni venom (BmV) on the cellular component of inflammatory responses and the mechanisms involved in this effect were investigated. The effects of venom on peritoneal and circulating leukocyte numbers and on the release of inflammatory mediators, such as LTB4, TXA2, PGD2, MIP-1 and KC, were assessed. The role of both m
Publicado em: 2009
4. Avaliação antiinflamatoria e antioxidante em ratos suplementados com uva (Vitis vinifera L.) na vigencia de colite induzida por acido trinitrobenzenosulfonico / Antiinflamatory and antioxidant evaluation in rats supplemented with frape (Vitis vinifera L.) in the presence of colitis induced by trinitrobenzene sulfonic acid
Despite the range of therapeutic possibilities, there is still no ideal treatment for inflammatory bowel disease (IBD), with the right profile of efficacy and safety. For this reason, it is of great interest to study agents with little side effect, which preferably form part of the diet and that treats / prevents such diseases. In this context, emerged the i
Publicado em: 2009
5. O papel dos neutrófilos na imunidade inata e no desenvolvimento da resposta imune adquirida ao parasita Leishmania amazonensis
Neutrophils provide the first line of defense against infection and also contribute to the initiation of inflammation. However the role of neutrophils in response to Leishmania is not clear yet. Moreover, most of the studies were performed in Leishmania major model of infection, hence there is no information on the involvement of neutrophils in the immune re
Publicado em: 2009
6. Neutrophil function and metabolism in individuals with diabetes mellitus
Neutrophils act as first-line-of-defense cells and the reduction of their functional activity contributes to the high susceptibilityto and severity of infections in diabetes mellitus. Clinical investigations in diabetic patients and experimental studies in diabetic rats and mice clearly demonstrated consistent defects of neutrophil chemotactic, phagocytic an
Brazilian Journal of Medical and Biological Research. Publicado em: 05/07/2007
7. The role of chemokines and chemokine receptors in eosinophil activation during inflammatory allergic reactions
Chemokines are important chemotactic cytokines that play a fundamental role in the trafficking of leukocytes to sites of inflammation. They are also potent cell-activating factors, inducing cytokine and histamine release and free radical production, a fact that makes them particularly important in the pathogenesis of allergic inflammation. The action of chem
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-11
8. Migração de neutrofilos induzida por enterotoxinas estafilococicas para a cavidade peritoneal de camundongos : participação de macrofagos
In this study, the role role of macrophages in the neutrophil migration induced by staphylococcal enterotoxins A (SEA) and B (SEB) into the mouse peritoneal cavity was investigated. SEA and SEB induced dose- and timedependent neutrophil migration into the mouse peritoneal cavity. This migration was potentiated when the macrophage population was increased by
Publicado em: 1999
9. Interleukin-8 is a major neutrophil chemotactic factor derived from cultured human gingival fibroblasts stimulated with interleukin-1 beta or tumor necrosis factor alpha.
Inflammatory mediators produced by cells in the gingiva have been implicated in the initiation and progression of periodontal disease, a common infectious disease. In this study, we examined the biological activity of neutrophil chemotactic factors and the kinetics of expression of interleukin-8 (IL-8) mRNA derived from normal gingival fibroblasts in respons
10. Adherence of neutrophils to cultured human microvascular endothelial cells. Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p150,95 glycoprotein family.
The process of neutrophil adhesion to and migration through the microvascular endothelium, an early event in the induction of the acute inflammatory response, has been attributed to the generation of extravascular chemoattractants. Although both chemotactic peptides and lipid mediators enhance neutrophil adherence in vitro and in vivo, the mechanism(s) invol
11. Differential contribution of chemotaxins and opsonins to neutrophil-mediated killing of Schistosoma mansoni larvae.
In neutrophil-mediated killing of schistosomula, antibody and serum complement serve two functions: (i) opsonization of the target pathogen and (ii) generation of cell-activating, chemotactic peptides. We studied neutrophil-mediated schistosomulum killing in experiments designed to isolate these functions of antibody and complement in the cell activation res
12. Chemotactic factor for tumor cells derived from the C5a fragment of complement component C5.
Previously, we have stablished that the fifth component of complement (C5) serves as an important source of mediators that have locomotory (chemotactic) activity for leukocytes and tumor cells. C5a, a fragment (Mr 11,200) derived from the NH2-terminal portion of the alpha chain of C5, is the major chemotactic peptide for leukocytes. The present studies demon