Chemokines Cc
Mostrando 1-12 de 111 artigos, teses e dissertações.
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1. [RETRACTED ARTICLE] Differential expression of CC chemokines (CCLs) and receptors (CCRs) by human T lymphocytes in response to different Aggregatibacter actinomycetemcomitans serotypes
ABSTRACT In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Recently, our research group has reported a differential immunogenicity when T lymphocytes were stimulated with these different serotypes. In particular, it was demonstrated that the serotype b of A. actinomycetemcomitans has a stronger capac
J. Appl. Oral Sci.. Publicado em: 2015-12
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2. Differential expression of CC chemokines (CCLs) and receptors (CCRs) by human T lymphocytes in response to different Aggregatibacter actinomycetemcomitans serotypes
In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Recently, our research group has reported a differential immunogenicity when T lymphocytes were stimulated with these different serotypes. In particular, it was demonstrated that the serotype b of A. actinomycetemcomitans has a stronger capacity to tr
J. Appl. Oral Sci.. Publicado em: 2015-10
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3. Receptor expression and responsiveness of human peripheral blood mononuclear cells to a human cytomegalovirus encoded CC chemokine
Human cytomegalovirus is a ubiquitous pathogen that infects the majority of the world's population. After long period of time co-evolving with human being, this pathogen has developed several strategies to evade host immune surveillance. One of the major trick is encoding homologous to those of the host organism or stealing host cellular genes that have sign
Braz J Infect Dis. Publicado em: 2015-08
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4. Imunopatologia da dengue: receptores de quimiocinas CC e células iNKT
Dengue virus (DENV), a mosquito-borne flavivirus, is a serious public health problem in many tropical countries. Immune mechanisms involved in the pathogenesis of DENV infection are not fully elucidated. Recent clinical data showed an association between levels of different CC chemokines in plasma and severity of dengue. In this regard, we evaluated the role
Publicado em: 2010
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5. Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors - how to make a dream come true
One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic mechanism. Better comprehension of the molecular mechanisms lead
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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6. Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians
The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the world. We investigated the distribution of t
Genetics and Molecular Biology. Publicado em: 16/01/2009
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7. Estudo da inibição do oxido nitrico sobre funções de eosinofilos humanos estimulados com eotaxina e RANTES in vitro / Study of nitric oxide inhibition in human eosinophil functions stimulated in vitro with eotaxin and RANTES
Eosinophils participate in the pathogenesis of many inflammatory diseases, including parasitic infections and allergic diseases. Of the allergic diseases, asthma is characterized by eosinophilia. Currently, asthma affects 300 million people in world, and is an important public health problem. Asthma is an inflammatory chronic disease that involves interactio
Publicado em: 2008
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8. The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models
Chemokines are a superfamily of low-molecular-weight cytokines that were initially described for their chemoattractant activity. It is now clear chemokines have several other activities that modulate immune processes. More than 50 chemokines ligands and at least 19 receptors have been described to date. Depending on the number of N-terminal cysteine residues
Memórias do Instituto Oswaldo Cruz. Publicado em: 2006-10
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9. Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system. Although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. Chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-04
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10. Estudo do envolvimento de CC quimiocinas e moléculas de adesão no recrutamento de linfócitos T γδ em reações inflamatórias de origem alérgica. / Study of the envolvement of CC-chemokines and adhesion moleculares conscription of lymphocyte T gama delta into the inflammatory reactions of allergic origin.
γδ T lymphocytes play an important role during allergic reactions, performing effector and regulatory functions. Chemokines and adhesion molecules are crucial for lymphocyte migration in response to several stimuli. However, the mechanisms by which γδ T lymphocytes migrate into the inflammatory site during allergic reactions have not been
Publicado em: 2006
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11. Efeito da rACLF, uma metalopeptidase recombinante da peçonha de Agkistrodon contortrix laticinctus, na viabilidade celular, expressão de citocinas e degradação de proteínas da matriz extracelular.
ACLF is a fibrinolytic non-hemorrhagic metallopeptidase from the venom of the snake Agkistrodon contortrix laticinctus. rACLF is synthesized as a zymogen (pro- ACLF) with 412 aminoacids, while the active form of enzyme has 222 aminoacids. The ORF (open reading frame) that codes for the peptidase was isolated (from a cDNA venom gland library of A. contortrix.
Publicado em: 2006
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12. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mi
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03