Characterization Of Inclusion Complexes
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
ABSTRACT This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state analysis was performed using X-ray powder diffr
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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2. Chlorhexidine: beta-cyclodextrin inhibits yeast growth by extraction of ergosterol
Chlorhexidine (Cx) augmented with beta-cyclodextrin (β-cd) inclusion compounds, termed Cx:β-cd complexes, have been developed for use as antiseptic agents. The aim of this study was to examine the interactions of Cx:β-cd complexes, prepared at different molecular ratios, with sterol and yeast membranes. The Minimal Inhibitory Concentration (MIC) against t
Brazilian Journal of Microbiology. Publicado em: 2012-06
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3. ESTUDO TEÓRICO DE ESTRUTURA, PROPRIEDADES E REATIVIDADE DE TRIGLICERÍDEOS E ÉSTERES DE ÁCIDOS GRAXOS ENVOLVIDOS NA PRODUÇÃO E COMPOSIÇÃO DO BIODIESEL
The present work aims the study of structural and thermodynamic properties for process involving triglycerides (TG), fatty acid esters (EAG) and biodiesel through theoretical and chemometrical methodologies. The study of the transesterification reaction of triglycerides (TG) using cyclodextrin (CD) as a potential catalyst were also carried out. Initially, th
Publicado em: 2010
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4. Physicochemical characterization of orally-active meglumine antimoniate/beta-cyclodextrin nanoassemblies: non-inclusion interactions and sustained drug release properties
β-cyclodextrin (β-CD) is widely used as a component of pharmaceutical formulations, classically to improve the solubility and oral bioavailability of poorly water-soluble drugs through formation of drug/β-CD inclusion complexes. Unexpectedly, the association of the highly water-soluble drug meglumine antimoniate (MA) with β-CD turned this antimonial comp
Brazilian Journal of Physics. Publicado em: 2009-04
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5. Attainment and characterization of binary and ternary complexes of simvastatin and cyclodextrins. / Obtenção e caracterização de complexos binários e ternários de sinvastatina e ciclodextrinas
O objetivo do presente trabalho foi obter complexos binários e ternários de sinvastatina (SNV) e ciclodextrinas (CDs) utilizando diferentes tipos de CDs, métodos de secagem e polímeros para selecionar aquele que proporcionam um maior aumento da solubilidade aquosa do fármaco. Inicialmente complexos com diferentes CDs, a α, β, γ, e hidroxi
Publicado em: 2009
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6. Inclusion of bixin, curcumin and betanin in cyclodextrin for application in food industry / Inclusão de bixina, curcumina e betanina em ciclodextrina para aplicação na industria de alimentos
The food industry has grown significantly in recent years, and when observing any type of food, it is clear that the visual impact caused by its color is more important than that caused by other factors. This attribute is one of the most important in the commercialization of foods and constitutes a criterion for the acceptance or non-acceptance of the produc
Publicado em: 2008
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7. Caracterização do complexo de inclusão ropivacaína: beta-ciclodextrina
Characteriza of the inclusion complex ropivacaine: beta-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with beta-cyclodextrin (beta-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:beta-CD complex by nuclear mag
Química Nova. Publicado em: 2007-10
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8. Preparação e caracterização físico-química de complexos de inclusão entre anestésicos locais e hidroxipropil-beta-ciclodextrina
S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl beta-cyclodextrin (HP-beta-CD) is used as a drug-carrier system. The aim of this work was to characterize inclusion complexes between LA and HP-beta-CD. The affinity constants determined at different pHs show favourable complexation. The release kinetics expe
Química Nova. Publicado em: 2007-08
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9. Avaliação biologica de uma pre-formulação de ropivacaina em hidroxipropil-beta-ciclodextrina produzida em processo escalonavel / Biological evaluation of a Ropivacaine formulation in hydroxypropyl-beta-cyclodextrin prepared in a scaled up process
Long-acting local anesthetics (LA) are worldwide used, mainly for surgical procedures. Ropivacaine (RVC) is a new, long-acting LA, with increased cardiovascular safety, in comparison to other anesthetics. The delivery of LA in carriers such as cyclodextrins has been investigated in order to increase the nonciceptive action and to reduce the systemic toxicity
Publicado em: 2007
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10. Nanoagregados baseados em ciclodextrinas em associação com a tetraciclina: caracterização fisico-química e avaliação antimicrobiana
Molecular self-assembling has been shown to be an efficient method to produce structures of few hundreds of nanometers in size. The supramolecular compounds made from (R)- cyclodextrin:tetracycline in aqueous solution were evaluated. The physicochemical interactions between â-cyclodextrin:tetracycline were characterized by dynamic light scattering (DLS), is
Publicado em: 2007
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11. Preparation and Solid-State Characterization of Inclusion Complexes Formed Between Miconazole and Methyl-β-Cyclodextrin
The aim of this study is to confirm the formation of inclusion complexes between miconazole (MCZ) and two derivatives of beta-cyclodextrin, methyl-beta-cyclodextrin (MβCD) and 2-hydroxypropyl-beta-cyclodextrin (HPβCD) in aqueous solution by phase solubility studies. Inclusion complexes with MβCD in the solid state were then prepared by different methods,
Springer US.
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12. Physicochemical Characterization of Efavirenz–Cyclodextrin Inclusion Complexes
Efavirenz (EFV) is an oral antihuman immunodeficiency virus type 1 drug with extremely poor aqueous solubility. Thus, its gastrointestinal absorption is limited by the dissolution rate of the drug. The objective of this study was to characterize the inclusion complexes of EFV with β-cyclodextrin (β-CD), hydroxypropyl β-CD (HPβCD), and randomly methylated
Springer US.