Cerulenin
Mostrando 1-12 de 116 artigos, teses e dissertações.
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1. Potential for using crude extract of Sarocladium oryzae for suppression of rice blast
Crude extract of an isolate of the fungus Sarocladium oryzae (CNPAF So 20G), containing the antimicrobial cerulenin, was produced and its antagonistic potential on the rice blast pathogen Magnaporthe oryzae was asessed. Cerulenin was detected in crude extract of S. oryzae through thin layer chromatography showing a Rf value of 0.63. The quantity of cerulenin
Trop. plant pathol.. Publicado em: 2014-02
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2. Importância do tecido adiposo marrom na ativação da termogênese induzida pela injeção central do C75, um inibidor da ácido graxo sintase / Importance of brown adipose tissue in the activation of thermogenesis induced by central injection of C75, a fatty acid synthase inhibitor
C75, a synthetic inhibitor of fatty acid synthase, causes anorexia and weight loss in rodents, but the underlying mechanisms are not totally known. Thus, the hypothesis tested in this work was that brown adipose tissue (BAT), an organ with important role for control of thermogenesis, could be involved in the anti-obesity effects of fatty acid synthase inhibi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/08/2012
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3. Estudo do papel biológico da enzima ácido graxo sintase (FASN) em células endoteliais derivadas dos vasos sanguíneos / Study of the biological role of the enzyme fatty acid synthase (FASN) in endothelial cells derived from blood vessels
Fatty acid synthase (FASN) is the anabolic enzyme with high expression and activity in several human malignancies, which is responsible for the endogenous synthesis of saturated fatty acids and consequently of the phospholipids present in cell membranes. Inhibition of FASN with orlistat (Xenical), an anti-obesity drug, is described as having anti-neoplastic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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4. Regulação do ciclo celular após inibição farmacológica da enzima ácido graxo sintase em linhagem derivada de melanoma murino, B16-F10 / Cell cycle regulation after pharmacological inhibition of the enzyme fatty acid synthase in murine melanoma line derived from, B16-F10
Ácido graxo sintase (FASN - fatty acid synthase) é a enzima metabólica responsável pela síntese endógena do ácido graxo saturado palmitato, a partir dos precursores acetil-CoA e malonil-CoA. Diversos estudos mostram que, em contraste com a maioria das células normais, FASN é altamente expressa em vários tipos de neoplasias malignas humanas, tais co
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/07/2010
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5. CARACTERIZAÇÃO MOLECULAR E BIOQUÍMICA DE CEPAS DE Saccharomyces cerevisiae UTILIZADAS NA CARACTERIZAÇÃO MOLECULAR E BIOQUÍMICA
Aiming the molecular characterization of Saccharomyces cerevisiae LBCM 427 strain, selected from fermentations vats of a cachaça distillery, several analysis using polymorphism analysis of DNA for the characterization/discrimination of this and the selvagem strains present in the origin place was used. Results showed that RAPD-PCR, mtDNA, and PCR using comp
Publicado em: 2007
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6. Effect of cerulenin on macromolecule synthesis in chemoheterotrophically and photoheterotrophically grown Rhodopseudomonas sphaeroides.
The antibiotic cerulenin causes the immediate cessation of phospholipid biosynthesis in both chemoheterotrophic and photoheterotrophic cultures of Rhodopseudomonas sphaeroides. Macromolecule biosynthesis in photoheterotrophic cells was unaffected by cerulenin for the first 2 h after antibiotic addition and then continued at a reduced rate for an additional 8
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7. Mitochondrial biogenesis during fungal spore germination: effects of the antilipogenic antibiotic cerulenin upon Botryodiplodia spores.
Germination of spores of the fungus Botryodiplodia theobromae was inhibited by the antilipogenic antibiotic cerulenin. The spores remained viable in the presence of the antibiotic, however, and after prolonged incubation they were able to overcome the inhibition. Cerulenin inhibition of germination was reversed by Tween 40 and Tween 60 (derivatives of palmit
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8. Inhibition of De Novo Fatty Acid Synthesis by the Antibiotic Cerulenin in Bacillus subtilis: Effects on Citrate-Mg2+ Transport and Synthesis of Macromolecules
Inhibition of de novo fatty acid biosynthesis by the antibiotic cerulenin in Bacillus subtilis stopped de novo synthesis of neutral lipids and phospholipids. The bacteria ceased growing but remained completely viable. Addition of 12-methyltetradecanoic acid and palmitic acid to the culture medium of cerulenin-treated cells restored growth of the bacteria, al
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9. Long-chain fatty acid assimilation By rhodopseudomonas sphaeroides.
Exogenously supplied long-chain fatty acids have been shown to markedly alleviate the inhibition of phototrophic growth of cultures of Rhodopseudomonas sphaeroides caused by the antibiotic cerulenin. Monounsaturated and polyunsaturated C18 fatty acids were most effective in relieving growth inhibition mediated by cerulenin. Medium supplementation with satura
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10. Inhibition of Lipid Synthesis in Escherichia coli Cells by the Antibiotic Cerulenin
The antibiotic cerulenin markedly inhibits the growth of Escherichia coli. The effects of the antibiotic on cellular syntheses were studied by measuring the incorporation of labeled precursors into lipids and macromolecules. During the first 40 min after the addition of cerulenin to a culture of growing cells, lipid synthesis was inhibited more than 90% and
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11. Inhibition of Vibrio harveyi bioluminescence by cerulenin: in vivo evidence for covalent modification of the reductase enzyme involved in aldehyde synthesis.
Bacterial bioluminescence is very sensitive to cerulenin, a fungal antibiotic which is known to inhibit fatty acid synthesis. When Vibrio harveyi cells pretreated with cerulenin were incubated with [3H]myristic acid in vivo, acylation of the 57-kilodalton reductase subunit of the luminescence-specific fatty acid reductase complex was specifically inhibited.
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12. Characterization of cerulenin-resistant mutants of Candida albicans.
Cerulenin, an inhibitor of fatty acid biosynthesis, has been used to study the role of the plasma membrane in germination of Candida albicans. To further elucidate this association, spontaneous, cerulenin-resistant mutants of C. albicans were isolated. Two of the mutants, 4918-2 and 4918-10, were compared biochemically with wild-type cells (4918). All strain