Central Nervous System Tumors Tumor Marker
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. IdentificaÃÃo de glicoproteÃnas em membrana de tumores primÃrios do sistema nervoso central utilizando lectinas vegetais acopladas a fluoresceÃna / Identification of membrane glycoproteins in tumors Primary central nervous system using lectins plant coupled with fluorescein
Lectinas sÃo proteÃnas que pertencem a um grupo heterogÃneo de molÃculas com capacidade de ligaÃÃo especÃfica e reversÃvel a carboidratos. Desde sua descoberta, as lectinas se tornaram importantes ferramentas para a investigaÃÃo de fenÃmenos como a adesÃo, a migraÃÃo e a proliferaÃÃo celular, em condiÃÃes normais e patolÃgicas. Durante o p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/02/2010
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2. ÉTUDE DES ALTÉRATIONS ÉPIGÉNÉTIQUES DES TUMEURS DES ENFANTS : LE CAS DES ÉPENDYMOMES ET DES NEUROBLASTOMES
During the last 10 years, a new mechanism of tumor development has been described: the hypermethylation of tumor suppressor genes. These epigenetic modifications were rarely studied in childhood cancer and large series of patients didnt exist before 2003. We studied two groups of childhood tumors; ependymoma and neuroblastome. Ependymomas (EP) represent the
Publicado em: 2006
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3. Molecular genetic approach to human meningioma: loss of genes on chromosome 22.
A molecular genetic approach employing polymorphic DNA markers has been used to investigate the role of chromosomal aberrations in meningioma, one of the most common tumors of the human nervous system. Comparison of the alleles detected by DNA markers in tumor DNA versus DNA from normal tissue revealed chromosomal alterations present in primary surgical spec
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4. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.
The MUC18 antigen is an integral membrane glycoprotein of 113 kDa whose expression on primary human melanomas correlates with poor prognosis and the development of metastatic disease. MUC18 is expressed only sporadically in benign melanocytic nevi and thin primary melanomas that have a low probability of metastasizing. However, with increasing tumor thicknes
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5. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1α and HIF-2α are key transcription regulators of phenotypic adaptation to low oxygen levels. Moreover, mouse gene disruption studies have implicated HIF-2α in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic n
The National Academy of Sciences.