Central Nervous System Sensitization
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Avaliação do impacto da presença de cefaleias primárias e do tempo de experiência de dor na efetividade do tratamento da disfunção temporomandibular / The impact of the coexistence of primary headaches and the time of pain experience on the efficacy of Temporomandibular Disorders (TMD) management
A migrânea e a cefaléia tensional são cefaléias primárias que surgem de estruturas não-mastigatórias, porém, a presença de sintomas de DTM, como a dor, pode influenciar de modo excitatório tais condições e vice-versa, influenciando no resultado final do tratamento. Esta pesquisa tem o objetivo principal de avaliar o impacto da presença de cefal�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/01/2012
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2. Multiple Serotonergic Mechanisms Contributing to Sensitization in Aplysia: Evidence of Diverse Serotonin Receptor Subtypes
The neurotransmitter serotonin (5-HT) plays an important role in memory encoding in Aplysia. Early evidence showed that during sensitization, 5-HT activates a cyclic AMP-protein kinase A (cAMP-PKA)-dependent pathway within specific sensory neurons (SNs), which increases their excitability and facilitates synaptic transmission onto their follower motor neuron
Cold Spring Harbor Laboratory Press.
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3. Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor.
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system that serves as a model for the human disease multiple sclerosis. We evaluated rolipram, a type IV phosphodiesterase inhibitor, for its efficacy in preventing EAE in the common marmoset Callithrix jacchus. In a blinded experimental design, clinical signs of EA
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4. Intrinsic responses to Borna disease virus infection of the central nervous system
Immune cells invading the central nervous system (CNS) in response to Borna disease virus (BDV) antigens are central to the pathogenesis of Borna disease (BD). We speculate that the response of the resident cells of the brain to infection may be involved in the sensitization and recruitment of these inflammatory cells. To separate the responses of resid
The National Academy of Sciences of the USA.
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5. Information storage in the nervous system of Aplysia: specific proteins affected by serotonin and cAMP.
To identify proteins that may be involved in the induction of long-term changes in the nervous system, we investigated whether specific proteins in pleural sensory neurons of Aplysia were affected by procedures that mimic those used to produce long-term sensitization. Using two-dimensional PAGE, we found that exposure to serotonin (5-hydroxytryptamine, 5-HT)
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6. Selective modulation of lipopolysaccharide-induced death and cytokine production by various muramyl peptides.
Pretreatment of animals with the adjuvant muramyl dipeptide enhances both the production of circulating tumor necrosis factor and the sensitivity to the lethal effect of a lipopolysaccharide (LPS) challenge. The present study examined the capacity of various adjuvant muramyl dipeptide derivatives to potentiate responsiveness to LPS administration. Cytokine l
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7. Quantitation of Contacts Among Sensory, Motor, and Serotonergic Neurons in the Pedal Ganglion of Aplysia
Present models of long-term sensitization in Aplysia californica indicate that the enhanced behavioral response is due, at least in part, to outgrowth of sensory neurons mediating defensive withdrawal reflexes. Presumably, this outgrowth strengthens pre-existing connections by formation of newsynapses with follower neurons. However, the relationship between
Cold Spring Harbor Laboratory Press.
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8. BDNF but not NT-4 is required for normal flexion reflex plasticity and function
Neurotrophins can directly modulate the function of diverse types of central nervous system synapses. Brain-derived neurotrophic factor (BDNF) might be released by nociceptors onto spinal neurons and mediate central sensitization associated with chronic pain. We have studied the role of BDNF and neurotrophin-4 (NT-4), both ligands of the trkB tyrosine kinase
The National Academy of Sciences.
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9. Involvement of Tumor Necrosis Factor Alpha and Interleukin-1β in Enhancement of Pentylenetetrazole-Induced Seizures Caused by Shigella dysenteriae
Neurologic manifestations, mainly convulsions, are the most frequent extraintestinal complications of shigellosis. We used an animal model to study the roles of tumor necrosis factor alpha (TNF-α) and interleukin-1 β (IL-1β) in Shigella-related seizures. Administration of Shigella dysenteriae 60R sonicate enhanced the sensitivity of mice to the proconvuls
American Society for Microbiology.