Cellular Targets
Mostrando 13-24 de 793 artigos, teses e dissertações.
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13. Ciclooxigenase-2 modula in vivo a expressão de marcadores da osteoclastogênese e genes envolvidos no metabolismo ósseo em resposta ao lipopolissacarídeo bacteriano / Ciclooxygenase-2 modulates in vivo the expression of osteoclastiogenesis makers and genes involved in bone metabolism in response to bacterial lipopolysaccharide
During an inflammatory response, several mediators are locally released in order to stimulate cellular and humoral immune response. Through the action of cyclooxygenase and lipoxygenase enzymes structural changes occur in the arachidonic acid chain leading to synthesis of prostaglandins or leukotrienes and lipoxins, respectively. Such mediators are responsib
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/06/2012
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14. Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis
Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulatory mechanisms involved in the aggressiveness of this cancer are still poorly understood. A better understanding of the biology, genetics and molecular mechanisms of gastric cancer would be useful in developing novel targeted approaches
Genetics and Molecular Biology. Publicado em: 13/07/2012
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15. Identificação e caracterização de alvos celulares da proteína NIG (NSP-Interacting GTPase) / Identification and characterization of cellular targets of the protein NIG (NSP-Interacting GTPase)
A proteína NSP (nuclear shuttle protein) de geminivírus facilita o transporte intracelular do DNA viral do núcleo para o citoplasma e atua juntamente com a proteína MP (movement protein) na propagação do DNA viral para células adjacentes. No entanto, o mecanismo pelo qual NSP medeia o movimento nucleocitoplasmático do DNA viral não é conhecido. Rec
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/07/2011
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16. Vias de sobrevivência e morte em queratinócitos submetidos ao estresse oxidativo e choque hiperosmótico / Survival and death signaling pathways in keratinocytes exposed to oxidative stress and hyperosmotic shock
The epidermis is constantly confronted with multiple environmental stressors. Changes in humidity or exposition to UV radiation affect the redox state and osmotic balance, modifying the physiological characteristics of the skin. In response to different stresses, epidermal keratinocytes can activate distinct signaling pathways and the balance between death a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2011
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17. Estudos estruturais e funcionais das proteínas cinases humanas Nek1 e Nek6 / Structural and functional studies of Nek1 Nek6 protein kinases
NIMA was identified and functionally characterized in Aspergillus nidulans as a critical Ser/Thr kinase for cell cycle progression. The mammalian Neks (NIMA-related kinases) represent an evolutionarily conserved family of 11 serine/threonine kinases that share 40-45% identity with NIMA N-terminal domain. Neks are associated to cell cyclerelated functions and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/03/2011
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18. Receptores A3 da adenosina: uma nova abordagem terapêutica no câncer
Cancer is a multi-factorial disease linked with different initiating causes, cofactors and promoters, and several types of cellular damage. Advancing knowledge on the cellular and molecular biology of the processes that regulate cell proliferation, cell differentiation and cellular responses to external signals, has provided a wealth of information about the
Química Nova. Publicado em: 2011
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19. Metabolism and brain cancer
Cellular energy metabolism is one of the main processes affected during the transition from normal to cancer cells, and it is a crucial determinant of cell proliferation or cell death. As a support for rapid proliferation, cancer cells choose to use glycolysis even in the presence of oxygen (Warburg effect) to fuel macromolecules for the synthesis of nucleot
Clinics. Publicado em: 2011
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20. Regulation of protein synthesis and the role of eIF3 in cancer
Maintenance of cell homeostasis and regulation of cell proliferation depend importantly on regulating the process of protein synthesis. Many disease states arise when disregulation of protein synthesis occurs. This review focuses on mechanisms of translational control and how disregulation results in cell malignancy. Most translational controls occur during
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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21. Estudo comparativo do efeito da Echinácea purpúrea e sorafenibe em células de adenocarcinoma renal humano em cultura / Comparative study of the effect of Echinacea purpurea and sorafenib in human renal adenocarcinoma cells in culture
Introduction: The renal cell carcinoma (CR) is relatively rare compared to other cancers. One of the most potent tumor mitogen, vascular endothelial growth factor, VEGF is regulated by numerous pathways, especially Ras and Akt, which are targets of many therapeutic agents, among them sorafenib. These signaling pathways play an important role in the developme
Publicado em: 2010
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22. Análise bioquímica inicial do proteassoma em populações do Trypanosoma cruzi com diferentes fenótipos de resistência ao benzonidazol
Differences in susceptibility to benznidazole (Bz) and nifurtimox (NFX) among populations of Trypanosoma cruzi may explain, at least in part, the differences in efficacy of treatment of Chagas disease. The proteasome has an important role in the degradation of normal proteins, damaged, mutated, or denatured, including the degradation of regulatory proteins o
Publicado em: 2010
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23. Association between clinicopathological variables and the immunohistochemical expression of Ezrin and CD44 in patients with osteosarcoma / Estudo da associação das variáveis clínico-patológicas com a expressão imunoistoquímica de Ezrin e CD44 em pacientes portadores de osteossarcoma
Metastasis is the most important prognostic factor in patients with osteosarcoma. Identification of genes that are crucial for metastatic dissemination is of great interest, not only to gain a basic understanding of the molecular and cellular processes involved, but also to provide the potential for new therapeutic targets. In relation to osteosarcoma, it ha
Publicado em: 2010
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24. Dengue-2 infection and the induction of apoptosis in human primary monocytes
Monocytes/macrophages are important targets for dengue virus (DENV) replication; they induce inflammatory mediators and are sources of viral dissemination in the initial phase of the disease. Apoptosis is an active process of cellular destruction genetically regulated, in which a complex enzymatic pathway is activated and may be trigged by many viral infecti
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12