Cell Signalling
Mostrando 13-24 de 545 artigos, teses e dissertações.
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13. A transient increase in total head phosphotyrosine levels is observed upon the emergence of Aedes aegypti from the pupal stage
Phosphorylation and dephosphorylation of protein tyrosine residues constitutes a major biochemical regulatory mechanism for the cell. We report a transient increase in the total tyrosine phosphorylation of the Aedes aegypti head during the first days after emergence from the pupal stage. This correlates with an initial reduction in total head protein tyrosin
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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14. Análises moleculares das vias de sinalização de morte celular originadas no retículo endoplasmático / Molecular analyses of cell death pathways signalling originated in the endoplasmic reticulum
Abiotic and biotic stresses are responsible for major losses in agricultural productivity world wise. Therefore, the understanding of mechanisms of plant stress response and adaptation to such conditions should provide the foundation for engineering plant stress tolerance and hence maximizing the yield of crops growing under adverse environmental conditions.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/02/2010
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15. Produção e caracterização de leptina e TcPTP1 recombinantes, proteínas ligadas ao metabolismo, sinalização celular e inflamação. / Production and characterization of recombinant leptin and TcPTP1, proteins linked to metabolism, cell sinalization and inflamation.
Leptin is predominantly secreted by adipocytes and plays an important role in the regulation of the energetic metabolism of mammals. Because of this, leptin is strongly involved in the regulation of obesity. After ligation, dimerization and activation of its specific receptor in the hypothalamus, leptin activates JAK kinases that phosphorylate STAT transcrip
Publicado em: 2010
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16. In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model
Background: ATP is an important signalling molecule in the peripheral and central nervous system. Both glioma growth and tumor resection induces cell death, thus liberating nucleotides to the extracellular medium. Nucleotides are hydrolyzed very slowly by gliomas when compared with astrocytes and induce neuronal cell death and glioma proliferation. The objec
Publicado em: 2010
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17. Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-β (TGF-β). This cytokine increases during Trypanosoma cruzi infection, modulating fibrosis and the parasite cell cycle. We studied Cx43 expression in cardiomyocytes exposed or not to TGF-β T. cruzi, or SB-
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12
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18. A century of research: what have we learned about the interaction of Trypanosoma cruzi with host cells?
Since the discovery of Trypanosoma cruzi and the brilliant description of the then-referred to "new tripanosomiasis" by Carlos Chagas 100 years ago, a great deal of scientific effort and curiosity has been devoted to understanding how this parasite invades and colonises mammalian host cells. This is a key step in the survival of the parasite within the verte
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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19. Ciliary Neurotrophic Factor (CNTF) effects over pancreatic islets function and survival / Efeitos do Ciliary Neurotrophic Factor (CNTF) sobre a função e sobrevivencia de ilhotas pancreaticas
Introduction: CNTF belongs to the IL-6 cytokine family and as such, it signals through gp130 receptor complex, activating many pathways depending on the cell-type, mainly STAT3, MAPK and PI3K. Its effects include increased neuron differentiation and/or survival, and are differentially expressed throughout the animal life. Meanwhile, pancreatic islets are ric
Publicado em: 2009
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20. Purinergic signalling: past, present and future
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's. The concept of purinergic cotransmission was formulated in 1976 and it is now recognized that ATP is a cotransmitter i
Brazilian Journal of Medical and Biological Research. Publicado em: 03/10/2008
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21. Role of nitric oxide and the cyclic guanosine monophosphate dependent patway on the adhesive properties leucocytes of sickle cell disease patients / Ação do oxido nitrico e da via dependente de guanosina monofosfato ciclico nas propriedades adesivas de leucocitos de pacientes com anemia falciforme
Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in sickle cell disease (SCD). Since nitric oxide (NO) bioavailability is decreased in SCD and NO may inhibit leukocyte adhesion, we determined whether stimulation of NO-signalling pathways can decrease the adhesive properties of neutrophils from SCD individuals (SCDneu). SCDne
Publicado em: 2008
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22. Natural compounds as modulators of transduction pathways in tumor cells / Copostos naturais como moduladores de vias de transdução de sinal em celulas tumorais
The search for compounds that specifically act on tumors, with low side effects, is a great aim in the studies related to cancer treatment. Many natural compounds isolated from plants have presented promising results as modulating agents of the signal transduction pathways in several types of tumors. Flavonoids, polyphenolic compounds largely distributed in
Publicado em: 2008
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23. Avaliação da função e plasticidade celuar de ilhotas pancreaticas em modelo de resistencia a insulina induzida por dexametosa em ratos / Analysis of dexamethasone treatment effcts on insulin secretion, molecular and biochemical parameters in submitted to protein restriction
Introduction and aims: Insulin binds to plasma membrane receptors leading to a variety of cellular responses. Malfunction in any of the insulin cell signalling pathways in target tissues may lead to several conditions and diseases, like hyperglycemia, insulin resistance and type 2 diabetes mellitus (T2DM). These effects may be experimentally reproduced using
Publicado em: 2008
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24. COX-2 expression analysis and signalling pathway mechanisms in human oral squamous cell carcinoma cell lines / "Análise da expressão e mecanismos de ação da proteína COX-2 em cultura de células de carcinoma epidermóide bucal humano"
Celecoxib, a cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drug, is a new anticarcinogenic agent. Its antitumor effects depend on the one hand on its COX-2-inhibiting potency, but on the other hand on COX-2-independent mechanisms, which until now have not been fully understood. The aim of this research was to study the effects of celecoxi
Publicado em: 2007