Cecal Ligation And Puncture Clp
Mostrando 1-12 de 62 artigos, teses e dissertações.
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1. MiR-106a aggravates sepsis-induced acute kidney injury by targeting THBS2 in mice model
Abstract Purpose To investigate the role and related mechanisms of miR-106a in sepsis-induced AKI. Methods Serum from sepsis and healthy patients was collected, sepsis mouse model was established by cecal ligation and puncture (CLP). TCMK-1 cells were treated with lipopolysaccharide (LPS) and transfected with THBS2-small interfering RNA (siTHBS2), miR-10
Acta Cir. Bras.. Publicado em: 19/08/2019
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2. Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway
Abstract Purpose: To explore the effect of milk fat globule-epidermal growth factor 8 (MFG-E8) on sepsis-induced acute kidney injury (SAKI). Methods: Male C57BL/6 mice were randomized to control, sham, CLP, CLP+PBS, and CLP+rmMFG-E8 groups. SAKI was induced by cecal ligation and puncture (CLP). Recombinant mouse MFG-E8 (rmMFG-E8) (20 μg/kg) or PBS (vehic
Acta Cir. Bras.. Publicado em: 28/02/2019
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3. Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis
Endoplasmic reticulum (ER) stress is a critical molecular mechanism involved in the pathogenesis of sepsis. Hence, strategies for alleviating this stress may be essential for preventing cardiovascular injuries under sepsis. Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. The purpose of this study was to investigate the protectiv
Braz J Med Biol Res. Publicado em: 14/11/2018
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4. Evaluation of Gamma Irradiation Effect on the Oxidative Stress Factors in Septic Rats Treated With Iranian Plant Essential Oils
ABSTRACT Cuminum cyminum L. (CM), Zataria multiflora Boiss. (ZM) and Mentha piperita L. (MP) are traditional medicinal plants with various pharmacological properties. This study was designed to assess the role of gamma irradiation -a modern decontamination method- in hepatoprotective effects of their essential oil (E.Os) in septic rats induced by experimenta
Braz. arch. biol. technol.. Publicado em: 29/10/2018
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5. The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study
ABSTRACT Introduction Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP). Materials and Methods Rat
Int. braz j urol.. Publicado em: 2017-04
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6. Copaiba oil effect on induced fecal peritonitis in rats
PURPOSE: To evaluate the effects of copaiba oil as a prophylactic and/or therapeutic substance on survival of rats subjected to cecal ligation and puncture, describing histopathological and oxidative stress findings.METHODS:Forty rats (Ratus norvegicus) were distributed into five study groups (N=8): Sham group (ShG): normal standard animals; Sepse group (Sep
Acta Cir. Bras.. Publicado em: 2015-08
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7. Copaiba oil effect under different pathways in mice subjected to sepsis
PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture.METHODS:Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with c
Acta Cir. Bras.. Publicado em: 2014-08
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8. Median lethal needle caliber in two models of experimental sepsis
PURPOSE: To estimate the median lethal needle caliber (LC50) of a new experimental sepsis model and compare it to the LC50 of the cecal ligation and puncture (CLP) sepsis model. METHODS: Male albino Wistar rats were studied (n=22). Animals were allocated into two study groups. In Group I, experimental sepsis was induced by cecal ligation and puncture.
Acta Cir. Bras.. Publicado em: 2014-01
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9. Clorhexidine as a factor that promotes peritoneal adhesions in rats with induced peritonitis
PURPOSE: To investigate the effects of chlorhexidine on the formation of adhesions and dilation of the colon at the oral end of anastomosis in the presence of peritonitis. METHODS: Peritonitis was induced in male Wistar rats by cecal ligation and puncture (CLP). Abdominal cavities were irrigated with tepid solutions containing 0.9% saline (SAL group; n=8) or
Acta Cir. Bras.. Publicado em: 2013-09
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10. Análise da concentração de nitrato no líquido cefalorraquidiano e da atividade enzimática das óxido nítrico sintases no hipotálamo de ratos submetidos à sepse experimental / Analysis of nitrate concentration in the cerebrospinal fluid and of the enzymatic activity of nitric oxide synthase in the hypothalamus of rats submitted to experimental sepsis.
Sepsis is defined as a systemic inflammatory response to an infectious stimulus. In the initial phase of the disease the secretion of vasopressin (AVP) is increased and late is observed a reduction, although high levels of inflammatory mediators and worsening of the hypotension, which are stimuli for the hormone secretion. Nitric oxide (NO) produced by the e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/09/2012
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11. Immune cells and oxidative stress in the endotoxin tolerance mouse model
Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune and inflammatory responses during a septic event. We describe a lipopolysaccharide tolerance mouse model to characterize the cellular and molecular alterations of im
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-01
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12. Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats
INTRODUCTION: The antibacterial effect of ozone (O3) has been described in the extant literature, but the role of O3 therapy in the treatment of certain types of infection remains controversial. OBJECTIVES: To evaluate the effect of intraperitoneal (i.p.) O3 application in a cecal ligation/puncture rat model on interleukins (IL-6, IL-10) and cytokine-induced
Clinics. Publicado em: 2010