Caveolae
Mostrando 1-12 de 153 artigos, teses e dissertações.
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1. Efeito dos oxisteróis na sinalização através de cavéolas e sua relevância na aterosclerose / Effect of oxysterols in cell signaling through caveolae and its relevance to atherosclerosis
Oxisteróis (por exemplo, 7hidroxicolesterol) são gerados por modificações oxidativas que ocorrem na molécula de colesterol. Podem ser encontrados em elevados níveis plasmáticos em pacientes com aterosclerose e como componentes da placa aterosclerótica. Considerando que o colesterol é o principal componente da cavéola (domínios específicos da memb
Publicado em: 2011
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2. Efeitos celulares do óxido nítrico em aorta de ratos hipertensos renais / Cellular effects of the nitric oxide in rat aorta from renal hypertensive rats
O relaxamento vascular induzido pelo óxido nítrico (NO) está prejudicado em aorta de ratos hipertensos renais (2R-1C). A nossa hipótese é de que o menor efeito do NO na aorta de ratos 2R-1C pode estar relacionada com a maior degradação do NO e/ou modificação das cavéolas no músculo liso vascular (MLV), considerando que o NO pode ser degradado rapi
Publicado em: 2008
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3. Mechanisms of arrhythmogenesis in cardiomyocytes and development of in vitro model of cardiac hypertrophy and fibrosis induced by Trypanosoma cruzi / Mecanismos envolvidos na arritmogenese em cardiomiocitos e desenvolvimento de modelo in vitro de fibrose e hipertrofia cardiaca induzidos por Trypanosoma cruzi
Infection with protozoan Trypanosoma cruzi causes Chagas disease that among its manifestations presents a severe cardiac form, which can induce arrhythmias and sudden death. In the first part of this work we studied the effect of T. cruzi infection on host cell coupling and calcium homeostasis in monolayered cardiac myocytes. In moments of invasion of the pa
Publicado em: 2007
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4. Efeito inibidor da finasterida sobre a enzima 5-alfa-redutase na prostata de gerbilos adultos (Meriones unguiculatus)
Prostatic deve1opment and differentiatíon are induced by androgens acting via mesenchymal-epithelial interactions, and during adult life the gland is maintained functionally active by reciprocal homeostatic stromal-epithelial interactions. Hormonal alterations, usually associated with the physical aspects of aging, leads to disruptions of this homeostatic i
Publicado em: 2003
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5. Caveolae from luminal plasmalemma of rat lung endothelium: microdomains enriched in caveolin, Ca(2+)-ATPase, and inositol trisphosphate receptor.
A distinctive feature of many endothelia is an abundant population of noncoated plasmalemmal vesicles, or caveolae. Caveolae have been implicated in many important cellular processes, including transcytosis, endocytosis, potocytosis, and even signal transduction. Because caveolae have not been purified from endothelial cell surfaces, little is known directly
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6. Cell Surface Orifices of Caveolae and Localization of Caveolin to the Necks of Caveolae in AdipocytesV⃞
Caveolae are noncoated invaginations of the plasma membrane that form in the presence of the protein caveolin. Caveolae are found in most cells, but are especially abundant in adipocytes. By high-resolution electron microscopy of plasma membrane sheets the detailed structure of individual caveolae of primary rat adipocytes was examined. Caveolin-1 and -2 bin
The American Society for Cell Biology.
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7. A detergent-free method for purifying caveolae membrane from tissue culture cells.
Current methods for purifying caveolae from tissue culture cells take advantage of the Triton X-100 insolubility of this membrane domain. To circumvent the use of detergents, we have developed a method that depends upon the unique buoyant density of caveolae membrane. The caveolae fractions that we obtain are highly enriched in caveolin. As a consequence we
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8. Intersectin Regulates Fission and Internalization of Caveolae in Endothelial Cells
Intersectin, a multiple Eps15 homology and Src homology 3 (SH3) domain–containing protein, is a component of the endocytic machinery in neurons and nonneuronal cells. However, its role in endocytosis via caveolae in endothelial cells (ECs) is unclear. We demonstrate herein by coimmunoprecipitation, velocity sedimentation on glycerol gradients, and cross-li
The American Society for Cell Biology.
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9. Reduction of caveolin and caveolae in oncogenically transformed cells.
Caveolae are flask-shaped non-clathrin-coated invaginations of the plasma membrane. In addition to the demonstrated roles for caveolae in potocytosis and transcytosis, caveolae may regulate the transduction of signals from the plasma membrane. Transformation of NIH 3T3 cells by various oncogenes leads to reductions in cellular levels of caveolin, a principal
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10. Caveolae Are Highly Immobile Plasma Membrane Microdomains, Which Are not Involved in Constitutive Endocytic TraffickingV⃞
To investigate whether caveolae are involved in constitutive endocytic trafficking, we expressed N- and C- terminally green fluorescent protein (GFP)-tagged caveolin- 1 fusion proteins in HeLa, A431, and Madin-Darby canine kidney cells. The fusion proteins were shown by immunogold labeling to be sorted correctly to caveolae. By using confocal microscop
The American Society for Cell Biology.
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11. Lipid Rafts and Caveolae and Their Role in Compartmentation of Redox Signaling
Membrane (lipid) rafts and caveolae, a subset of rafts, are cellular domains that concentrate plasma membrane proteins and lipids involved in the regulation of cell function. In addition to providing signaling platforms for G-protein-coupled receptors and certain tyrosine kinase receptors,
Mary Ann Liebert.
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12. Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: A pathway to overcome cell barriers to drug and gene delivery
Site-directed pharmacodelivery is a desirable but elusive goal. Endothelium and epithelium create formidable barriers to endogenous molecules as well as targeted therapies in vivo. Caveolae provide a possible, yet unproven, transcellular pathway to overcome such barriers. By using an antibody- and subfractionation-based strategy, we generated a monoclonal an
The National Academy of Sciences.