Case Deletion Model
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. T-cell/myeloid mixed-phenotype acute leukemia with monocytic differentiation and isolated 17p deletion
Mixed phenotype acute leukemia is a rare subtype of leukemia that probably arises from a hematopoietic pluripotent stem cell. The co-expression of two of myeloid, B- or T-lymphoid antigens is the hallmark of this disease. Herein, the case of a 28-year-old female patient is reported who presented with hemoglobin of 5.8 g/dL, white blood cell count of 138 × 1
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-07
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2. Modelos não lineares sob a classe de distribuições misturas da escala skew-normal / Nonlinear models based on scale mixtures skew-normal distributions
Neste trabalho estudamos alguns aspectos de estimação e diagnóstico de influência global e local de modelos não lineares sob a classe de distribuição misturas da escala skew-normal, baseado na metodologia proposta por Cook (1986) e Poon &Poon (1999). Os modelos não lineares heteroscedásticos também são discutidos. Esta nova classe de modelos const
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/07/2010
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3. The mechanism of U insertion/deletion RNA editing in kinetoplastid mitochondria.
Recent advances in in vitrosystems and identification of putative enzymatic activities have led to the acceptance of a modified 'enzyme cascade' model for U insertion/deletion RNA editing in kinetoplastid mitochondria. Models involving the transfer of uridines (Us) from the 3'-end of gRNA to the editing site appear to be untenable. Two types of in vitrosyste
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4. Multigene families and vestigial sequences
Random duplication and deletion events generate complex genomes carrying a large amount of dispensable sequences. We have simulated such events in a computer model. We followed the evolution of a genome carrying at least one copy of each type of gene. Partial duplications and deletions of genes generated nonfunctional vestigial sequences that were dispensabl
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5. RNA polymerase-dependent mechanism for the stepwise T7 phage DNA transport from the virion into E. coli.
The influence of rifampicin, streptolydigin, tetracycline and chloramphenicol on phage DNA transport from the T7 virion into the E. coli cell was studied. It has been found that the DNA transport proceeds in at least three stages. During the initial stage the phage injects into the host cell the left approximately 10 per cent of its DNA molecule. The entranc
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6. Effect of a recA mutation on cholera toxin gene amplification and deletion events.
The cholera toxin operon (ctxAB) is located on a 7-kilobase pair variable genetic element which undergoes genetic duplication and amplification events in Vibrio cholerae. Amplification of the ctx genetic element was investigated by substituting the resident ctx loci of two V. cholerae strains with a DNA fragment encoding resistance to kanamycin. Although the
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7. Two different but related mechanisms are used in plants for the repair of genomic double-strand breaks by homologous recombination.
Genomic double-strand breaks (DSBs) are key intermediates in recombination reactions of living organisms. We studied the repair of genomic DSBs by homologous sequences in plants. Tobacco plants containing a site for the highly specific restriction enzyme I-Sce I were cotransformed with Agrobacterium strains carrying sequences homologous to the transgene locu
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8. Yeast telomerase RNA: A flexible scaffold for protein subunits
In the yeast Saccharomyces cerevisiae, distinct regions of the 1.2-kb telomerase RNA (TLC1) bind to the catalytic subunit Est2p and to accessory proteins. In particular, a bulged stem structure binds the essential regulatory subunit Est1p. We now show that the Est1p-binding domain of the RNA can be moved to three distant locations with retention of telomeras
National Academy of Sciences.
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9. Persistence of Tandem Arrays: Implications for Satellite and Simple-Sequence Dnas
Recombination processes acting on tandem arrays are suggested here to have probable intrinsic biases, producing an expected net decrease in array size following each event, in contrast to previous models which assume no net change in array size. We examine the implications of this by modeling copy number dynamics in a tandem array under the joint interaction
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10. Endogenous Lipogenic Regulators of Spore Balance in Aspergillus nidulans†
The ability of fungi to produce both meiospores and mitospores has provided adaptive advantages in survival and dispersal of these organisms. Here we provide evidence of an endogenous mechanism that balances meiospore and mitospore production in the model filamentous fungus Aspergillus nidulans. We have discovered a putative dioxygenase, PpoC, that functions
American Society for Microbiology.
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11. A Salmonella fim Homologue in Citrobacter freundii Mediates Invasion In Vitro and Crossing of the Blood-Brain Barrier in the Rat Pup Model
From the invasive Citrobacter freundii strain 3009, an invasion determinant was cloned, sequenced, and expressed. Sequence analysis of the determinant showed high homology with the fim determinant from Salmonella enterica serovar Typhimurium. The genes of the invasion determinant directed invasion of recombinant Escherichia coli K-12 strains into human epith
American Society for Microbiology.
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12. Functional analysis of the true late human cytomegalovirus pp28 upstream promoter: cis-acting elements and viral trans-acting proteins necessary for promoter activation.
As a model for analyzing the regulation of human cytomegalovirus late genes, we investigated the 28-kDa phosphoprotein (pp28) gene region. Transcripts of 1.6 and 1.3 kb were expressed in wild-type human cytomegalovirus-infected cells but not in cells infected with a DNA-negative temperature-sensitive mutant (ts66), indicating that DNA replication is absolute