Cardiovascular System And Cardiomyocytes
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Ca2+/Calmodulin-dependent kinase II delta B is essential for cardiomyocyte hypertrophy and complement gene expression after LPS and HSP60 stimulation in vitro
Inflammation plays an important role in the development of cardiovascular diseases (CVDs), suggesting that the immune system is a target of therapeutic interventions used for treating CVDs. This study evaluated mechanisms underlying inflammatory response and cardiomyocyte hypertrophy associated with bacterial lipopolysaccharide (LPS)- or heat shock protein 6
Braz J Med Biol Res. Publicado em: 15/07/2019
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2. The role of oxytocin in cardiovascular regulation
Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neur
Braz J Med Biol Res. Publicado em: 18/03/2014
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3. Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
Quercetin (Que), a plant-derived flavonoid, has multiple benefical actions on the cardiovascular system. The current study investigated whether Que postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. Male Sprague-Dawley rats were randomly allocated to 5 groups (20
Braz J Med Biol Res. Publicado em: 24/09/2013
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4. Estudo do efeito de nanopartículas magnéticas biocompatíveis no sistema cardiovascular de ratos e investigação do processo de captura e exocitose das nanoestruturas por cardiomiócitos / Study of the effect of magnetic nanoparticles biocampatible in the rat cardiovascular system and investigation of capture process and exocytosis for cardiomyocytes of nanostructures
Fluidos magnéticos (FM) consistem de nanopartículas magnéticas formadas por ferritas dispersas em um líquido carreador formando uma composição coloidal. Estas nanoestruturas têm atraído a atenção da comunidade biomédica já que possuem aplicações na área de carreadores de fármacos, detecção de doenças, e podem, ainda, contribuir para o trat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/05/2012
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5. Estudo do efeito de nanopartículas magnéticas biocompatíveis no sistema cardiovascular de ratos e investigação do processo de captura e exocitose das nanoestruturas por cardiomiócitos / Study of the effect of magnetic nanoparticles biocampatible in the rat cardiovascular system and investigation of capture process and exocytosis for cardiomyocytes of nanostructures
Fluidos magnéticos (FM) consistem de nanopartículas magnéticas formadas por ferritas dispersas em um líquido carreador formando uma composição coloidal. Estas nanoestruturas têm atraído a atenção da comunidade biomédica já que possuem aplicações na área de carreadores de fármacos, detecção de doenças, e podem, ainda, contribuir para o trat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/05/2012
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6. Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system
The purinergic system is composed of mononucleosides, mononucleoside polyphosphates and dinucleoside polyphosphates as agonists, as well as the respective purinergic receptors. Interest in the role of the purinergic system in cardiovascular physiology and pathophysiology is on the rise. This review focuses on the overall impact of dinucleoside polyphosphates
Blackwell Publishing Ltd.
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7. Restricted inactivation of serum response factor to the cardiovascular system
Serum response factor (SRF) directs programs of gene expression linked to growth and muscle differentiation. To investigate the role of SRF in cardiovascular development, we generated mice in which SRF is knocked out in >80% of cardiomyocytes and >50% of vascular smooth muscle cells (SMC) through SM22α-Cre-mediated excision of SRF's promoter and first exon.
National Academy of Sciences.
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8. Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors
Neuropeptide Y (NPY) has been shown to participate in the cardiovascular response mediated by the sympathetic system. In this report, we investigate the growth factor properties of NPY on cardiac myocytes. Mitogen-activated protein kinases (MAPK) are key signaling molecules in the transduction of trophic signals. Therefore, the role of NPY in inducing MAPK a
The National Academy of Sciences.
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9. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver.
We have developed a transgenic animal model to investigate the effects of overexpression of rat prorenin on the cardiovascular system. Two transgenic rat lines were generated in which rat prorenin expression was directed to the liver by a human alpha1-antitrypsin promoter. Liver-specific expression was confirmed by RNase protection assay. Plasma prorenin con
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10. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease. We used the Cre-loxP system to generate an endothelial cell-specific mutation of Pten (Tie2CrePten) in mice. Tie2CrePtenflox/+ mice displayed enhanced tumorigenesis due to an increase in angiogenesis driven by vascular growth f
Cold Spring Harbor Laboratory Press.
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11. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein
Cardiomyocyte apoptosis is a critical process in the pathogenesis of ischemic and diabetic cardiomyopathy, but the mechanisms are not fully understood. Thioredoxin-interacting protein (TXNIP) has recently been shown to have deleterious effects in the cardiovascular system and we therefore investigated whether it may also play a role in diabetes-associated ca
American Physiological Society.
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12. A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia–reperfusion injury
The cytokine erythropoietin (EPO) protects the heart from ischemic injury, in part by preventing apoptosis. However, EPO administration can also raise the hemoglobin concentration, which, by increasing oxygen delivery, confounds assignment of cause and effect. The availability of EPO analogs that do not bind to the dimeric EPO receptor and lack erythropoieti
National Academy of Sciences.