Cardiac Myocyte
Mostrando 1-12 de 248 artigos, teses e dissertações.
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1. DACT1 Involvement in the Cytoskeletal Arrangement of Cardiomyocytes in Atrial Fibrillation by Regulating Cx43
Abstract Objective: To determine the role of the dishevelled binding antagonist of beta catenin 1 (DACT1) in the cytoskeletal arrangement of cardiomyocytes in atrial fibrillation (AF). Methods: The DACT1 expression and its associations with the degree of fibrosis and β-catenin in valvular disease patients were analyzed by immunohistochemistry and Masson�
Braz. J. Cardiovasc. Surg.. Publicado em: 23/09/2019
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2. Odanacatib Inhibits Resistin-induced Hypertrophic H9c2 Cardiomyoblast Cells Through LKB1/AMPK Pathway
ABSTRACT Odanacatib (ODN) is a selective inhibitor of cathepsin K. The cysteine protease cathepsin K has been implicated in cardiac hypertrophy. Resistine is an adipokine which is identified to promote cardiac hypertrophy. Here, we hypothesize that ODN mitigates resistin-induced myocyte hypertrophy. Cell surface area and protein synthesis were measured after
Braz. arch. biol. technol.. Publicado em: 17/08/2017
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3. Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
ABSTRACT PURPOSE: To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI). METHODS: Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and pr
Acta Cir. Bras.. Publicado em: 2016-03
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4. Early neonatal echocardiographic findings in an experimental rabbit model of congenital diaphragmatic hernia
This study aimed to demonstrate that congenital diaphragmatic hernia (CDH) results in vascular abnormalities that are directly associated with the severity of pulmonary hypoplasia and hypertension. These events increase right ventricle (RV) afterload and may adversely affect disease management and patient survival. Our objective was to investigate cardiac fu
Braz J Med Biol Res. Publicado em: 03/02/2015
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5. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats
OBJECTIVES: The present study was performed to investigate 1) whether aerobic exercise training prior to myocardial infarction would prevent cardiac dysfunction and structural deterioration and 2) whether the potential cardiac benefits of aerobic exercise training would be associated with preserved morphological and contractile properties of cardiomyocytes
Clinics. Publicado em: 2013-04
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6. Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats
We determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive rats (SHR) randomly divided into the following groups: sedentary for 8 weeks (SED-8), sedentary for 12 weeks (SED-12), treadmill-running trained for 8 weeks (TRA, 16 m/min, 60 min/
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11
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7. Hemodynamic, morphometric and autonomic patterns in hypertensive rats - renin-angiotensin system modulation
BACKGROUND: Spontaneously hypertensive rats develop left ventricular hypertrophy, increased blood pressure and blood pressure variability, which are important determinants of heart damage, like the activation of renin-angiotensin system. AIMS: To investigate the effects of the time-course of hypertension over 1) hemodynamic and autonomic patterns (blood pres
Clinics. Publicado em: 2010
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8. Estimulação multidirecional de celulas cardiacas : instrumentação e experimentação / Multidirectional stimulation of cardiac cells : instrumentation and experimentation
O procedimento mais efetivo para reverter arritmias cardíacas consiste na aplicação de choques elétricos de alta intensidade, como e o caso da desfibrilação. Estimulação com campos elétricos (E) elevados, entretanto, exerce efeitos deletérios sobre o músculo cardíaco, podendo causar disfunções elétrica e contrátil e até a morte celular. Priv
Publicado em: 2009
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9. Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure
The present investigation was undertaken to study the effect of β-blockers and exercise training on cardiac structure and function, respectively, as well as overall functional capacity in a genetic model of sympathetic hyperactivity-induced heart failure in mice (α2A/α2CArKO). α2A/α2CArKO and their wild-type controls were studied for 2 months, from 3 to
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-09
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10. Modelo experimental e intrumentação para estudo da função do reticulo sarcoplasmatico no transporte de Ca 2+ no coração / Experimental model and instrumentation for the study of sarcoplasmic reticulum Ca 2+ transport in the heart
The goal of this work was to develop an instrument for simultaneous measurement of cell shortening and cytosolic Ca2+ concentration ([Ca2+]i), by using the fluorescent Ca2+ indicator fluo-3. The instrument was applied to study the uptake of cytosolic Ca2+ by the sarcoplasmic reticulum (RS) Ca2+- ATPase (SERCA, the main transporter responsible for cell relaxa
Publicado em: 2007
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11. Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats
The effect of swimming training (ST) on vagal and sympathetic cardiac effects was investigated in sedentary (S, N = 12) and trained (T, N = 12) male Wistar rats (200-220 g). ST consisted of 60-min swimming sessions 5 days/week for 8 weeks, with a 5% body weight load attached to the tail. The effect of the autonomic nervous system in generating training-induc
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-12
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12. Sinalização em miocitos cardiacos submetidos a aumentos de tensão
A variety of stimuli, such as hemodynamic overload, can lead to an increase in mechanical stress on cardiomyocytes that can be compensed by the development of a hypertrophyc phenotype. The hypertrophyc response is characterized by a rapid and coordinate activation of intracellular signaling pathways that regulate gene expression and results in a hypertrophyc
Publicado em: 2004