Carcinogenesis
Mostrando 13-24 de 854 artigos, teses e dissertações.
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13. Phytotoxins eliminated by milk: a review
RESUMO: O leite é uma mistura complexa de lipídeos suspensos em solução aquosa de proteínas e pode ser veículo de diversos contaminantes, mas, geralmente, não é uma importante via de excreção de tóxicos. O principal problema é a exposição repetida, como ocorre com a ingestão de plantas tóxicas, e seu potencial perigo para os animais que conso
Pesq. Vet. Bras.. Publicado em: 02/05/2019
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14. THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA
RESUMO Racional : Acredita-se que a via Wnt é uma das mais importantes da sinalização envolvidas na carcinogênese gástrica. Objetivos : Analisar a expressão das proteínas das vias Wnt canônicas e não-canônicas no carcinoma gástrico e relacionar sua expressão com as variáveisclinicopatológicas. Método : Foram coletadas 72 amostras de c
ABCD, arq. bras. cir. dig.. Publicado em: 07/01/2019
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15. Methylation of p16 ink4a promoter is independent of human papillomavirus DNA physical state: a comparison between cervical pre-neoplastic and neoplastic samples
BACKGROUND Epigenetic modifications in host cells, like p16 ink4a methylation, have been considered as putative complementary mechanisms for cancer development. Because only a small proportion of infected women develop cervical cancer, other factors might be involved in carcinogenesis, either independently or in association with high-risk human papillomavir
Mem. Inst. Oswaldo Cruz. Publicado em: 17/12/2018
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16. Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom
Abstract Background: In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can interact with specific integrins to inhibit their activities in cell-cell and cell-ECM interactions. These molecules, known to inh
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/11/2018
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17. FGFR1 is an independent prognostic factor and can be regulated by miR-497 in gastric cancer progression
Fibroblast growth factor receptor 1 (FGFR1) has been reported in gastric cancer to be a prognostic factor. However, miR-497-targeted FGFR1 has not been explored in the carcinogenesis of gastric cancer. The present study intended to revalidate the prognostic significance of FGFR1 in patients with gastric cancer, and the mechanism of miR-497-regulated FGFR1 wa
Braz J Med Biol Res. Publicado em: 23/11/2018
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18. Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was ver
Clinics. Publicado em: 18/10/2018
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19. Epidemiology and biology of cutaneous human papillomavirus
Cutaneous human papillomaviruses (HPVs) include β- and γ-HPVs, in addition to a small fraction of α-HPVs. β-HPVs were first isolated from patients with the rare genetic disorder Epidermodysplasia verruciformis, and they are associated with the development of nonmelanoma skin cancer at sun-exposed skin sites in these individuals. Organ transplant recipien
Clinics. Publicado em: 09/08/2018
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20. Vitamin D levels in actinic keratosis: a preliminary study
Abstract: Background: Recent studies that investigated the effect of vitamin D on skin cancer risk have exhibited inconsistent results. Objective: The aim of the study was to evaluate vitamin D status in patients with actinic keratosis. Methods: A cross-sectional study was conducted on 31 patients with actinic keratosis and 29 healthy controls. Serum vita
An. Bras. Dermatol.. Publicado em: 2018-08
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21. Dual effect of Algerian propolis on lung cancer: antitumor and chemopreventive effects involving antioxidant activity
Abstract The purpose of our study was to divulge the antiproliferative effect of an ethanolic extract of Algerian propolis (EEP) in the human lung adenocarcinoma cell line (A549) and reveal the chemopreventive role against benzo(a)pyrene-induced lung carcinogenesis in albino Wistar rats. Cytotoxicity of EEP was evaluated using the MTT assay and cell adhesion
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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22. The role of Phosphatidylinositol 3 kinase (PI3K) and Cycloxygenase-2 (COX2) in carcinogenesis of colorectal polyps
RESUMO Objetivos: Determinar a expressão imuno-histoquímica de Fosfatase homóloga a tensina (PTEN), Fosfatidilinositol-3-cinase (PI3K), Ciclooxigenase-2 (COX2) e um marcador de proliferação (Ki67) em pólipos colorretais e correlacionar com dados clínicos e patológicos buscando sua correspondência na carcinogênese. Métodos: Revisados 297 pólipos
J. Coloproctol. (Rio J.). Publicado em: 2018-03
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23. Absence of TERT promoter mutations in colorectal precursor lesions and cancer
Abstract Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the
Genet. Mol. Biol.. Publicado em: 19/02/2018
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24. Short-term carcinogenesis evaluation of Casearia sylvestris
Abstract Casearia sylvestris Sw., Salicaceae, is an important medicinal plant widely used in Brazil for the treatment of various cardiovascular disorders. This species was included as of interest by Brazilian Unified Health System. Although preclinical studies described cardiovascular protective effects and apparent absence of toxicity, no studies have evalu
Rev. bras. farmacogn.. Publicado em: 2017-10