Car T Cell
Mostrando 1-12 de 55 artigos, teses e dissertações.
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1. Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
ABSTRACT Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independently of human leukocyte antigen (HLA), is composed by
Hematol., Transfus. Cell Ther.. Publicado em: 2020-06
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2. Terapia gênica: avanços, desafios e perspectivas
RESUMO A habilidade de fazer modificações pontuais no genoma humano tem sido o objetivo da medicina desde o conhecimento do DNA como unidade básica da hereditariedade. Entende-se terapia gênica como a capacidade do melhoramento genético por meio da correção de genes alterados (mutados) ou modificações sítio-específicas, que tenham como alvo o trat
Einstein (São Paulo). Publicado em: 2017-09
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3. Influence of carvacrol and thymol on the physiological attributes, enterotoxin production and surface characteristics of Staphylococcus aureus strains isolated from foods
This study evaluated the influence of the phenolic compounds carvacrol (CAR) and thymol (THY) on some physiological characteristics and on the modulation of the secretion of some staphylococcal virulence factors, that is, coagulase and enterotoxin. This study also investigated possible mechanisms for the establishment of the anti-staphylococcal activity of t
Braz. J. Microbiol.. Publicado em: 19/03/2013
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4. Sequence change in the HS2-LCR and Gg-globin gene promoter region of sickle cell anemia patients
The fetal hemoglobin (HbF) levels and ßS-globin gene haplotypes of 125 sickle cell anemia patients from Brazil were investigated. We sequenced the Gg- and Ag-globin gene promoters and the DNase I-2 hypersensitive sites in the locus control regions (HS2-LCR) of patients with HbF level disparities as compared to their ßS haplotypes. Sixty-four (51.2%) patien
Brazilian Journal of Medical and Biological Research. Publicado em: 11/01/2008
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5. Anemia falciforme: aspéctos genéticos e imunológicos associados à IL-8 e ao TNF-α. / Sickle cell disease: genetic and immunological aspects associated with IL-8 e ao TNF-α.
Sickle hemoglobin (HbS) presents high frequency in Brazil, and Bahia is the state with highest prevalence of sickle cell anemia. The disease has a heterogeneous clinical outcome, characterized by vaso-occlusive and infection events, contributing to a chronic proinflammatory condition. The aim of the study was investigate molecular, phenotypic and immunologic
Publicado em: 2007
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6. Sickle cell anemia in Salvador-Bahia: phenotype and molecular characterization and search of specific gene sequences potentially important to gamma genes expression of the fetal hemoglobin. / Anemia falciforme em Salvador-Bahia: caracterização fenotípica, molecular e de seqüências gênicas potencialmente importantes na expressão dos genes gama da hemoglobina fetal.
Introdução. A hemoglobina S (HbS) resulta da troca de nucleotídeo (GAG GTG) no sexto codon do gene da globina beta, levando à substituição do ácido glutâmico por valina na cadeia da globina beta. A anemia falciforme ou a homozigose para a HbS, freqüentemente apresenta manifestações clínicas heterogêneas, fortemente relacionadas aos níveis de he
Publicado em: 2005
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7. Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor
The human coxsackievirus and adenovirus receptor (CAR) represents the primary cellular site of adenovirus attachment during infection. An understanding of the mechanisms regulating its expression could contribute to improving efficacy and safety of adenovirus-based therapies. We characterized regulation of CAR expression in a 3D cell culture model of human b
The National Academy of Sciences.
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8. Immunohematological Reference Ranges for Adults from the Central African Republic
A survey was carried out on 150 healthy adults to establish hematological reference ranges for human immunodeficiency virus (HIV)-negative adults from the Central African Republic (CAR). Immunohematological mean values, medians, and 95th-percentile reference ranges were established. Mean values were as follows: leukocyte (WBC) counts, 5.28 × 109/liter (male
American Society for Microbiology.
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9. Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naïve T cells
The inability to easily and efficiently introduce genes into primary T cells has hampered the investigation of the pathways controlling T cell fate. To enable adenoviral-mediated gene transfer into normal naïve T cells, transgenic (Tg) mice expressing the coxsackie/adenovirus receptor (CAR) in their T cell compartment were constructed. Whereas naïve T
The National Academy of Sciences.
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10. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones
We investigated the direct effects of changes in free ionized extracellular calcium concentrations ([Ca2+]o) on osteoblast function and the involvement of the calcium-sensing receptor (CaR) in mediating these responses. CaR mRNA and protein were detected in osteoblast models, freshly isolated fetal rat calvarial cells and murine clonal osteoblastic 2T3 cells
National Academy of Sciences.
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11. 5′ CArG degeneracy in smooth muscle α-actin is required for injury-induced gene suppression in vivo
CC(A/T)6GG–dependent (CArG-dependent) and serum response factor–dependent (SRF-dependent) mechanisms are required for gene expression in smooth muscle cells (SMCs). However, an unusual feature of many SMC-selective promoter CArG elements is that they contain a conserved single G or C substitution in their central A/T-rich region, which reduces binding af
American Society for Clinical Investigation.
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12. Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways.
The human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates the transcription of several cellular genes. This function is thought to play a critical role in the Tax-dependent transformation step in HTLV-1 leukemogenesis. Tax activates transcription via three enhancers: the cyclic AMP response element (CRE)-like sequence, the kappaB element, and the