Cancer Vaccines
Mostrando 1-12 de 107 artigos, teses e dissertações.
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1. Enhancing immune effects of a DNA vaccine against kidney cancer using CD40L as an adjuvant
The use of specific combinations of antigens and adjuvant represents a promising approach for increasing the immunogenicity of DNA vaccines. In the present study, we evaluated the immunity and antitumor effects of DNA vaccines with G250 as the target antigen in a mouse model of renal cell carcinoma. We constructed two recombinant plasmids, pVAX1-G250 and pVA
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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2. HPV VACCINE ADHERENCE AMONG ADOLESCENTS: INTEGRATIVE REVIEW
RESUMO Objetivo: identificar os fatores associados à adesão de adolescentes à vacina contra o Papilomavírus Humano. Método: trata-se de revisão integrativa da literatura realizada nas bases de dados Medical Literature Analysis and Retrieval System Online e Web of Science, Cumulative Index to Nursing and Allied Health Literature, Literatura Latino-A
Texto contexto - enferm.. Publicado em: 04/11/2019
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3. A pilot study on the identification of human papillomavirus genotypes in tongue cancer samples from a single institution in Ecuador
The relationship between human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma has been established. However, data from Ecuador is limited. The objective of this study was to characterize HPV infection in Ecuadorian patients with tongue cancer. Fifty-three patients with tongue cancer treated at the tertiary referral center Sociedad de Lucha Co
Braz J Med Biol Res. Publicado em: 08/10/2018
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4. Discrepancies in the evaluation of the safety of the human papillomavirus vaccine
Despite being more than ten years since its introduction, global acceptance to the human papillomavirus (HPV) vaccine is still low. The immunogenetic background of the host, and HPV antigen recognition, are important in natural HPV infection, and should be taken into account in the understanding of adverse autoimmune reactions by the HPV vaccine in certain g
Mem. Inst. Oswaldo Cruz. Publicado em: 28/05/2018
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5. Generation of potent cytotoxic T lymphocytes against in male patients with non-muscle invasive bladder cancer by dendritic cells loaded with dying T24 bladder cancer cells
ABSTRACT Background In order to induce a potent cytotoxic T lymphocyte (CTL) response in dendritic cell (DC)-based immunotherapy for bladder cancer, various tumor antigens can be loaded onto DCs. Objective The aim of this study was to establish a method of immunotherapy for male patients with non-muscle invasive bladder cancer (NMIBC), using bladder canc
Int. braz j urol.. Publicado em: 2017-08
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6. Papillomaviruses: a systematic review
Abstract In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomavir
Genet. Mol. Biol.. Publicado em: 16/02/2017
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7. Construction of a fusion plasmid containing the PSCA gene and cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and its anti-tumor effect in an animal model of prostate cancer
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding, and which has a greater affinity. Fusion of specific antigens to extracellular domain of CTLA4 represents a promising approach to increase the immunogenicity of DNA vaccines. In this study, we evaluated this inter
Braz J Med Biol Res. Publicado em: 24/10/2016
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8. The immunogenicity and anti-tumor effects of a lung cancer DNA vaccine harboring a MUC-1 and GM-CSF fusion gene
ABSTRACT DNA vaccines have been shown to be an effective approach to induce antigen-specific cellular and humoral immunity. However, the inability of DNA vaccines to elicit strong immune responses in clinical trials limits the application of DNA vaccines. Here, we developed a new DNA vaccine based on MUC1, which has been suggested as a potential target for l
Braz. arch. biol. technol.. Publicado em: 27/06/2016
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9. Prevalence and genotype distribution of human papillomavirus: implications for cancer screening and vaccination in Henan province, China
Abstract: INTRODUCTION: To provide information for cervical cancer screening and vaccination in Henan province, China, the distribution of human papillomavirus (HPV) was analyzed. METHODS: The HPV genotypes were detected using gene array and flow-through hybridization. RESULTS: Overall, 38.1% (1,536/4,033) of the women were human papillomavirus deoxyrib
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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10. New insights on the development of fungal vaccines: from immunity to recent challenges
Fungal infections are emerging as a major problem in part due to high mortality associated with systemic infections, especially in the case of immunocompromised patients. With the development of new treatments for diseases such as cancer and the acquired immune deficiency syndrome pandemic, the number of immunosuppressed patients has increased and, as a cons
Mem. Inst. Oswaldo Cruz. Publicado em: 24/11/2015
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11. Live bacterial vaccine vectors: An overview
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be engineered to deliver recombinant heterologous antigens to stimulate the host immune system, while still offering good levels of safety. A key feature of these live vectors is their capacity to stimulate mucosal as well as humoral and/or cellular systemic immunity. This enab
Braz. J. Microbiol.. Publicado em: 2014-12
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12. Production of L1 protein from different types of HPV in Pichia pastoris using an integrative vector
Human papillomavirus (HPV) infection is the most common sexually transmitted disease in the world and is related to the etiology of cervical cancer. The most common high-risk HPV types are 16 and 18; however, the second most prevalent type in the Midwestern region of Brazil is HPV-33. New vaccine strategies against HPV have shown that virus-like particles (V
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-12