Camp Signaling
Mostrando 1-12 de 351 artigos, teses e dissertações.
-
1. Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation
Hepatocellular carcinoma (HCC) is the third highest cause of cancer death worldwide. In general, the disease is diagnosed at an advanced stage when potentially curative therapies are no longer feasible. For this reason, it is very important to develop new therapeutic approaches. Retinoic acid (RA) is a natural derivative of vitamin A that regulates important
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
-
2. Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common human life-threatening monogenic disorders. The disease is characterized by bilateral, progressive renal cystogenesis and cyst and kidney enlargement, often leading to end-stage renal disease, and may include extrarenal manifestations. ADPKD is caused by mutation in one of two gen
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-07
-
3. Alvos moleculares em meduloblastoma : um estudo in vitro
Meduloblastoma é o tumor intracranial mais comum em crianças, provavelmente derivado de células precursoras da camada granular externa do cerebelo durante seu desenvolvimento. O tratamento padrão consiste em cirurgia, radioterapia e quimioterapia, que produzem graves sequelas nos pacientes e garantem uma sobrevida baixa, o que demonstra a necessidade de
Publicado em: 2010
-
4. Identificação e caracterização funcional dos elementos cis-regulatorios da miostatina / Identification and functional characterization of the cis-regulatory elements of myostatin
The Myostatin protein (also known as GDF8) is a member of the transforming growth factor-β (TGF-β) superfamily and is expressed almost exclusively in skeletal muscle, both in the embryo and in the adult, where the protein circulates in the blood flow. It was initially identified in 1997 by MCPHERRON et al., and since then many studies have been dem
Publicado em: 2009
-
5. Interação funcional entre o receptor do peptídeo liberador de gastrina e a via de sinalização do AMP cíclico/proteína quinase A : um estudo in vitro e in vivo
Muitas evidências demonstram que o peptídeo liberador de gastrina (GRP) é um fator de crescimento que afeta funções neuroendócrinas, incluindo proliferação e diferenciação celular, comportamento alimentar, formação de memória, respostas a estresses, desenvolvimento de neoplasias, desordens neurológicas e psiquiátricas. Porém, os eventos molec
Publicado em: 2009
-
6. Avaliação do efeito relaxante do BAY 41-2272 em detrusor isolado de coelhos / Evaluation of relaxant effect of BAY 41-2272 in rabbit isolated detrusor
Overactive bladder (OAB) is a highly prevalent condition that affects millions of people worldwide with a profound effect on quality of life. The bladder overactivity is related to spontaneous contractions of the detrusor smooth muscle causing an increase in the intravesical pressure and consequently stimulation of the micturirion reflex. Evidences suggest t
Publicado em: 2009
-
7. RIC-8B, a putative GEF of the olfactory system, interacts with Gαolf, Gβ1 e Gγ13 / Ric-8B, uma GEF putativa do sistema olfatório, interage com Gαolf, Gβ1 e Gγ13
The mammalian olfactory system detects small amounts of thousands of different chemical compounds. Odorant perception starts when an odorant in the air binds to an olfactory receptor (OR). ORs belong to the super family of G-protein coupled receptors (GPCRs). Even though the odorant signaling pathway is well known, little is known about its modulators. In 20
Publicado em: 2008
-
8. Caracterização dos receptores P2 em eosinófilos de ratos e possíveis papéis funcionais. / Characterization of the P2 receivers in eosinophils of rats and possible functional papers.
ATP and other nucleotides can be released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds take on new roles as intercellular signaling molecules that elicit a broad spectrum of physiological responses through the activation of numerous cell surface receptors. These nucleotides a
Publicado em: 2007
-
9. Caracterização da expressão e função de receptores recombinantes do hormônio folículo-estimulante. / Characterization of expression and function of recombinant follicle-stimulating receptors.
The follicle stimulating hormone receptor (FSHR) is a member of a family of Gprotein-coupled receptors that has a large aminoterminal domain, rich in leucine repeats. The FSHR, together with the luteinizing hormone receptor, controls gonadal function in vertebrates. Mutations in the FSHR can alter its binding and signaling properties, and drastically affect
Publicado em: 2006
-
10. Regulation of the expression of the gene plg1 that code for pectin lyase in Penicillium griseoroseum / Regulação da expressão do gene plg1 que codifica pectina liase em Penicillium griseoroseum
Penicillium griseoroseum has been considered a promising species for industrial application because of its capacity to produce pectin lyase (PL) and polygalacturonase. When P. griseoroeum is grown in the presence of glucose, plg1 gene transcripts are detected at low levels, evidencing the effects of catabolic repression. However, in the absence of the natura
Publicado em: 2006
-
11. AMPc - Sinalização intracelular: um software educacional
Chemicals binding to membrane receptors may induce events within the cell changing its behavior. Since these events are simultaneous and hard to be understood by students, we developed a computational model to dynamically and visually explore the cAMP signaling system to facilitate its understanding. The animation is shown in parts, from the hormone-receptor
Química Nova. Publicado em: 2004-06
-
12. Evidence for a modulation of neutral trehalase activity by Ca2+ and cAMP signaling pathways in Saccharomyces cerevisiae
Saccharomyces cerevisiae neutral trehalase (encoded by NTH1) is regulated by cAMP-dependent protein kinase (PKA) and by an endogenous modulator protein. A yeast strain with knockouts of CMK1 and CMK2 genes (cmk1cmk2) and its isogenic control (CMK1CMK2) were used to investigate the role of CaM kinase II in the in vitro activation of neutral trehalase during g
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-01