Calcium Signaling
Mostrando 1-12 de 635 artigos, teses e dissertações.
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1. Biochemical and Molecular Mechanisms of Glucose Uptake Stimulated by Physical Exercise in Insulin Resistance State: Role of Inflammation
Resumo A obesidade associada à inflamação sistêmica induz resistência à insulina (RI), com consequente hiperglicemia crônica. Este processo envolve o aumento na liberação de citocinas pró-inflamatórias, ativação da enzima c-Jun N-terminal cinase (JNK), do fator nuclear kappa-B (NF-κB) e dos receptores do tipo Toll 4 (TLR4). Dentre as ferramenta
Arq. Bras. Cardiol.. Publicado em: 21/10/2019
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2. Inhibitory effect of Astragalus polysaccharide on osteoporosis in ovariectomized rats by regulating FoxO3a /Wnt signaling pathway
Abstract Purpose: To investigate inhibitory effect of Astragalus polysaccharide (APS) on osteoporosis in ovariectomized rats by regulating FoxO3a/Wnt2 signaling pathway. Methods: Postmenopausal osteoporosis (PMOP) animal model was developed by excising the bilateral ovaries of rats. The model rats were administered with APS (200 mg/kg, 400 mg/kg, 800 mg/
Acta Cir. Bras.. Publicado em: 03/06/2019
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3. 6-Bromoindirubin-3’-oxime promotes osteogenic differentiation of canine BMSCs through inhibition of GSK3β activity and activation of the Wnt/β-catenin signaling pathway
This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively af
An. Acad. Bras. Ciênc.. Publicado em: 21/03/2019
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4. Retinoic acid increases the effect of bone morphogenetic protein type 2 on osteogenic differentiation of human adipose-derived stem cells
Abstract Bone morphogenetic protein type 2 (BMP-2) and retinoic acid (RA) are osteoinductive factors that stimulate endogenous mechanisms of bone repair which can be applied on management of osseous defects in oral and maxillofacial fields. Objective Considering the different results of RA on osteogenesis and its possible use to substitute/potency BMP-2 ef
J. Appl. Oral Sci.. Publicado em: 21/02/2019
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5. Extracellular calcium increases fibroblast growth factor 2 gene expression via extracellular signal-regulated kinase 1/2 and protein kinase A signaling in mouse dental papilla cells
Abstract We previously reported that elevated extracellular calcium (Ca2+) levels increase bone morphogenetic protein 2 expression in human dental pulp (hDP) cells. However, it is unknown whether extracellular Ca2+ affects the expression of other growth factors such as fibroblast growth factor 2 (FGF2). Objective: The present study aimed to examine the effe
J. Appl. Oral Sci.. Publicado em: 14/05/2018
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6. Nitric oxide modulates ATP-evoked currents in mouse Leydig cells
Testosterone synthesis within Leydig cells is a calcium-dependent process. Intracellular calcium levels are regulated by different processes including ATP-activated P2X purinergic receptors, T-type Ca2+ channels modulated by the luteinizing hormone, and intracellular calcium storages recruited by a calcium-induced calcium release mechanism. On the other hand
Braz J Med Biol Res. Publicado em: 15/03/2018
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7. Identification of the difference in the pathogenesis in heart failure arising from different etiologies using a microarray dataset
OBJECTIVES: Clinically, patients with chronic heart failure arising from different etiologies receive the same treatment. However, the prognoses of these patients differ. The purpose of this study was to elucidate whether the pathogenesis of heart failure arising from different etiologies differs. METHODS: Heart failure-related dataset GSE1145 was obtained
Clinics. Publicado em: 2017-10
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8. Mecanismos de proteção da distrofia muscular : estudo proteômico e terapia farmacológica / Protective mechanisms of muscular dystrophy : proteomic study and pharmacological therapy
In Duchenne Muscular Dystrophy (DMD) and in the mdx mice model of DMD, the lack of dystrophin leads to muscle degeneration. The pathogenesis of DMD is related to sarcolemmal fragility, mechanical stress and increased influx of calcium in muscle fibers, due to dysfunction of ion channels, such as the stretch-activated calcium channels. The knowledge of the pr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2012
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9. Arginine induces GH gene expression by activating NOS/NO signaling in rat isolated hemi-pituitaries
The amino acid arginine (Arg) is a recognized secretagogue of growth hormone (GH), and has been shown to induce GH gene expression. Arg is the natural precursor of nitric oxide (NO), which is known to mediate many of the effects of Arg, such as GH secretion. Arg was also shown to increase calcium influx in pituitary cells, which might contribute to its effec
Braz J Med Biol Res. Publicado em: 2012-11
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10. The sodium pump controls the frequency of action-potential-induced calcium oscillations
Calcium plays a significant role in a number of cellular processes, like muscle contraction, gene expression, synaptic plasticity, signal transduction, but the significance of calcium oscillations (CaOs) is not yet completely understood in most of the cell types. It is a widely accepted fact that CaOs are a frequency encoded signal that allows a cell to use
Comput. Appl. Math.. Publicado em: 2012
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11. Ações da epitestosterona através de um mecanismo de membrana em células de Sertoli : implicações no desenvolvimento sexual
Introduction: Epitestosterone is the 17¿-epimer of testosterone. It seems to possess an antiandrogenic activity, as well as a neuroprotective effect. The mechanism of action of epitestosterone has not been elucidated. Objective: The aim of this work is to investigate the non-classical effect of epitestosterone on the membrane of Sertoli cells from testis of
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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12. Papel de SOCS2 na resposta imune e função cardíaca durante a infecção experimental por Trypanosoma cruzi
Infection with Trypanosoma cruzi induces robust inflammation that limits parasite proliferation but may result in Chagas heart disease. The 5-Lipoxygenase pathway induces suppressor of cytokine signaling(SOCS)2 expression, an important regulator of immune responses. Here, we investigated the role of SOCS2 for the pathogenesis of T. cruzi infection. We invest
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011