Busulfan
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Late chimerical status after bone marrow transplantation in severe aplastic anemia according to two different preparatory regimens
ABSTRACT Background: This study investigated the influence of two conditioning regimens on the chimerical status of 104 patients with acquired severe aplastic anemia. Methods: Patients were monitored for at least 18 months after related bone marrow transplantation and reaching partial or complete hematologic recovery. Group I patients (n = 55) received 200
Hematol., Transfus. Cell Ther.. Publicado em: 2018-06
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2. Anti-CD3 Antibody Ameliorates Transfusion-Associated Graft-Versus-Host Disease in a Chemotherapy-Based Mouse Model With Busulfan and Fludarabine
ABSTRACT To establish a transfusion-associated graft-versus-host disease (TA-GVHD) mouse model with busulfan and fludarabine for effective treatment evaluation. BALB/c (H-2d) mice were injected with busulfan (15 mg/kg) and fludarabine (30 mg/kg) twice a day for 4 days. The mice were transfused with 106 T cell-depleted bone marrow (TCD-BM )and cells in differ
Braz. arch. biol. technol.. Publicado em: 18/05/2017
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3. Clinical and histological study of permanent alopecia after bone marrow transplantation
Abstract: BACKGROUND: Permanent alopecia after bone marrow transplantation is rare, but more and more cases have been described, typically involving high doses of chemotherapeutic agents used in the conditioning regimen for the transplant. Busulfan, classically described in cases of irreversible alopecia, remains associated in recent cases. The pathogenesis
An. Bras. Dermatol.. Publicado em: 2015-12
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4. Outcomes in relapsed Hodgkin's lymphoma treated with autologous and allogeneic hematopoietic cell transplantation at the Pontificia Universidad Católica de Chile
Introduction: Hodgkin's lymphoma is a highly curable disease. Autologous and reduced intensity allogeneic hematopoietic cell transplantations are alternatives to treat relapsed patients. Here, we report on the results of one service using these procedures. Methods: All patients who underwent transplantations in our institution between 1996 and 2014 were ret
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-06
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5. Monitoração terapêutica do bussulfano oral, após uso de dose teste e durante condicionamento, em pacientes submetidos a transplante alogênico de células-tronco hematopoiéticas / Therapeutic monitoring of oral busulfan, after the use of test dose and during conditioning regimen, in patients undergoing allogeneic hematopoietic stem cell transplantation
Busulfan is an alkylating agent, used for conditioning patients undergoing hematopoietic stem cell transplantation (HSCT). It presents narrow therapeutic range and high variability in pharmacokinetics among patients and doses in the same patient. High plasma concentrations (>1000 ng mL-1) have been related to toxicity, such as sinusoidal obstruction syndrome
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
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6. Monitoração terapêutica do bussulfano oral, após uso de dose teste e durante condicionamento, em pacientes submetidos a transplante alogênico de células-tronco hematopoiéticas / Therapeutic monitoring of oral busulfan, after the use of test dose and during conditioning regimen, in patients undergoing allogeneic hematopoietic stem cell transplantation
O bussulfano é um agente alquilante utilizado em regimes de condicionamento para ablação medular em pacientes submetidos a transplante de células-tronco hematopoiéticas (TCTH). Apresenta estreita faixa terapêutica e grande variabilidade farmacocinética entre pacientes e entre doses no mesmo paciente. Em altas concentrações plasmáticas (>1000 ng mL-
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
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7. Determinação de bussulfano em plasma através de cromatografia líquida de alta eficiência com detector de arranjo de diodos e derivatização com dietilditiocarbamato de sódio
A high performance liquid chromatographic-diode array detection method for the determination of busulfan in plasma was developed and validated. Sample preparation consisted of protein precipitation followed by derivatization with sodium diethyldithiocarbamate and liquid-liquid extraction with methyl-tert-butyl ether. Chromatograms were monitored at 277 nm. S
Química Nova. Publicado em: 2012
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8. Padronização das técnicas de transplante de espermatogônias em Zebrafish (Danio rerio) e utilização desta espécie como modelo experimental para se investigar a biologia das espermatogônias tronco em teleósteos
A espermatogênese é um complexo processo de desenvolvimento celular no qual um pequeno número de espermatogônias tronco (SPGTs) origina um grande número de espermatozóides, os quais, como vetores gênicos, são capazes de propagar as o genoma da espécie. Este processo ocorre continuamente durante toda a vida reprodutiva do animal, devido ao potencial
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/03/2011
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9. Conditioning regimen using busulfan plus melphalan in hematopoietic stem cell transplantation: can this conditioning regimen be used in autologous or allogeneic transplantation for acute leukemia?
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-06
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10. Busulfan and melphalan as conditioning regimen for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission
BACKGROUND: Allogeneic hematopoietic stem cell transplantation with HLA-identical donors has been established for the treatment of acute myeloid leukemia patients for over 30 years with a cure rate of 50% to 60%. OBJECTIVES: To analyze the overall survival of patients and identify factors that influence the outcomes of this type of transplant in patients in
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-06
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11. Transplante singênico e xenogênico de espermatogônias-tronco em tilápias-nilóticas (Oreochromis niloticus) adultas
O transplante de células germinativas consiste na remoção de espermatogônias-tronco do testículo de um animal doador e a transferência das mesmas para o testículo de um animal receptor, sem espermatogênese endógena, onde estas células irão se desenvolver e formar espermatozóides maduros com características genéticas do doador. Esta técnica apr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/04/2010
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12. A retrospective comparison of cyclophosphamide plus antithymocyte globulin with cyclophosphamide plus busulfan as the conditioning regimen for severe aplastic anemia
Allogeneic hematopoietic stem cell transplantation (AHSCT) is the treatment of choice for young patients with severe aplastic anemia (SAA). The association of antithymocyte globulin (ATG) and cyclophosphamide (CY) is the most frequently used conditioning regimen for this disease. We performed this retrospective study in order to compare the outcomes of HLA-m
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-03