Brown Adipose Tissue
Mostrando 1-12 de 130 artigos, teses e dissertações.
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1. Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity
ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is among the activators that can stimulate thermogenesis in the white adipose tissue and brown adipose tissue. People with obesity have elevated blood levels of FGF21, but also develop resistance to its action, impairing its beneficial role. Inversely, clinical treatments to weight loss has been pointe
Arch. Endocrinol. Metab.. Publicado em: 2020-08
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2. Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats
Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic
Braz J Med Biol Res. Publicado em: 10/10/2019
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3. Memory impairments and increased GFAP expression in hippocampal astrocytes following hypercaloric diet in rats
RESUMO Objetivo: A inflamação hipotalâmica e a superexpressão da proteína glial fibrilar ácida (GFAP) em astrócitos são bem descritas em animais obesos, assim como déficits cognitivos e de memória. Como o hipocampo desempenha importante papel na consolidação de informações, esta investigação teve como objetivo observar a função da memória
Arq. Neuro-Psiquiatr.. Publicado em: 23/09/2019
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4. A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
Abstract: The aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein, 74%-carbohydrate) for 45 days; C45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed
An. Acad. Bras. Ciênc.. Publicado em: 01/07/2019
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5. Litter Size Reduction Induces Metabolic and Histological Adjustments in Dams throughout Lactation with Early Effects on Offspring
In the present study we analyzed morphological and metabolic alterations in dams nursing small litters and their consequences to offspring throughout lactation. Offspring sizes were adjusted to Small Litter (SL, 3 pups/ dam) and Normal Litter (NL, 9 pups/ dam). Body weight, food intake, white adipose tissue (WAT) content, histological analysis of the pancrea
An. Acad. Bras. Ciênc.. Publicado em: 21/03/2019
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6. Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats
Maternal smoking is a risk factor for progeny obesity. We have previously shown, in a rat model of neonatal tobacco smoke exposure, a mild increase in food intake and a considerable increase in visceral adiposity in the adult offspring. Males also had secondary hyperthyroidism, while females had only higher T4. Since brown adipose tissue (BAT) hypofunction i
Braz J Med Biol Res. Publicado em: 19/04/2018
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7. Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats
ABSTRACT Here, we evaluated whether the exposure of rats to a cafeteria diet pre- and/or post-weaning, alters histological characteristics in the White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and liver of adult male offspring. Female Wistar rats were divided into Control (CTL; fed on standard rodent chow) and Cafeteria (CAF; fed with the cafeteria
An. Acad. Bras. Ciênc.. Publicado em: 2017-12
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8. Importância do tecido adiposo marrom na ativação da termogênese induzida pela injeção central do C75, um inibidor da ácido graxo sintase / Importance of brown adipose tissue in the activation of thermogenesis induced by central injection of C75, a fatty acid synthase inhibitor
C75, a synthetic inhibitor of fatty acid synthase, causes anorexia and weight loss in rodents, but the underlying mechanisms are not totally known. Thus, the hypothesis tested in this work was that brown adipose tissue (BAT), an organ with important role for control of thermogenesis, could be involved in the anti-obesity effects of fatty acid synthase inhibi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/08/2012
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9. A Interleucina 1 beta desempenha um papel termogênico na inflamação hipotalâmica induzida por dieta em ratos / Interleukin 1 beta plays a thermogenic role in diet-induced hypothalamic inflammation
In experimental obesity, changes in hypothalamic function play an important role in the anomalous regulation of food intake and energy expenditure. Recent studies have shown that a low-grade hypothalamic inflammation is an important factor contributing to hypothalamic dysfunction in this context. Cytokines such as TNF alfa , IL6 and IL10 have been studied in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/03/2011
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10. Weight loss and brown adipose tissue reduction in rat model of sleep apnea
Background -: Obesity is related to obstructive sleep apnea-hypopnea syndrome (OSAHS), but its roles in OSAHS as cause or consequence are not fully clarified. Isocapnic intermittent hypoxia (IIH) is a model of OSAHS. We verified the effect of IIH on body weight and brown adipose tissue (BAT) of Wistar rats. Methods: Nine-month-old male breeders Wistar rats o
Publicado em: 2010
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11. Role of adrenergic receptor b1 e b2 in facultative thermogenesis. / Papel dos receptores adrenérgicos b1 e b2 na termogênese facultativa.
The body weight of animals tends to be relatively stable over long periods of time. Situations of caloric restriction or increase in intake of calories lead to compensatory physiological changes that resist the effects of these disorders. In fact, the energy expenditure increases in animals treated with diet hypercaloric called facultative thermogenesis, in
Publicado em: 2009
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12. Investigação da ação neuroprotetora do fator neurotrofico ciliar (CNTF) conjugado com peptideo contendo dominio de translocação de proteina (PTD) / Investigation of neuroprotective action of ciliary neurotrophic factor (CNTF) fused to a protein transduction domain (PTD)
Ciliary neurotrophic factor (CNTF) is known as a neuroprotective agent on motoneurons after peripheral nerve section in neonatal rats and adult mice. However, side effects like weight loss and caquexia have limited its clinical use. A promising approach for the avoidance of such side effects is the fusion of a protein transduction domain (PTD) with CNTF. Pre
Publicado em: 2009