Brain Injuries Therapy
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Efeitos da oxigenoterapia hiperbárica após isquemia hepática segmentar normotérmica e reperfusão, em coelhos:: Avaliação bioquímica, morfológica e da microcirculação hepática pelo ultra-som contrastado
Interruption of blood flow to an organ or tissue (ischemia) and subsequent reperfusion lead to an acute inflammatory response that may cause significant cellular damage and organ dysfunction. It is called ischemia/reperfusion injury. Hepatic ischemia/reperfusion injury is characterized by circulatory and metabolic derangements, liver dysfunction and tissue d
Publicado em: 2008
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2. Efeitos da hemodiluição normovolêmica aguda com Ringer lactato e hidroxietilamido na hipertensão intracraniana: estudo em cães com lesão criogênica do cérebro / Effects of acute normovolemic hemodilution with lactated Ringers solution and hydroxyethylstarch in intracranial hypertension: study in dogs with cryogenic brain injury
Objective: Brain injury is responsible for significant morbidity and mortality in trauma patients, but controversy still exists over optimal fluid management for these patients. This study aimed to investigate the effects of acute hemodilution with hydroxyethyl starch (HES) or lactated Ringers solution (LR) in intracranial pressure(ICP) and cerebral perfusio
Publicado em: 2007
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3. Pro/con ethics debate: Should mechanical ventilation be continued to allow for progression to brain death so that organs can be donated?
Organ transplants continue to redefine medical frontiers. Unfortunately, current demand for organs far surpasses availability, waiting lists are long and many people die before the organ they desperately need becomes available. One proposed way to increase organ availability is to admit patients to the ICU with severe neurological injuries, for a trial of th
BioMed Central.
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4. The unrecognized epidemic of blunt carotid arterial injuries: early diagnosis improves neurologic outcome.
OBJECTIVE: To determine the benefit of screening for blunt carotid arterial injuries (BCI) in patients who are asymptomatic. SUMMARY BACKGROUND DATA: Blunt carotid arterial injuries have the potential for devastating complications. Published studies report 23% to 28% mortality rates, with 48% to 58% of survivors having permanent severe neurologic deficits. M
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5. Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol
Beyond the key role in reproductive and cognitive functions, estrogens have been shown to protect against neurodegeneration associated with acute and chronic injuries of the adult brain. Current hypotheses reconcile this activity with a direct effect of 17β-estradiol (E2) on neurons. Here we demonstrate that brain macrophages are also involved in E2 ac
National Academy of Sciences.
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6. The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery
Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is elevated in the neuronal cell bodies before the spinal axons are cut. Prophylactic injection of cAMP, however, is useless as therapy for spinal injuries. We now show that the phosphodiesterase 4 (PDE4) inhibitor rolipram (which readily
National Academy of Sciences.
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7. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults by largely unknown mechanisms. Apoptosis and necrosis have been proposed as mechanisms of cellular demise, and either could be the target of actions of EPO. This study evaluates whether antiapoptotic mechanisms can account for the neuroprotective actions of EPO. Sy
The National Academy of Sciences.
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8. Management of raised intracranial pressure.
This review has been written at an unfortunate time. Novel questions are being asked of the old therapies and there is an abundance of new strategies both to lower ICP and protect the brain against cerebral ischaemia. In the United Kingdom, the problem is to ensure that appropriate patients continue to be referred to centres where clinical trials of high qua