Brain Damage Chronic
Mostrando 1-12 de 43 artigos, teses e dissertações.
-
1. Histopathology of murine toxoplasmosis under treatment with dialyzable leukocyte extract
BACKGROUND Dialyzable leukocyte extracts (DLEs) contain molecules smaller than 10 kDa with biological activity in receptor organisms. Primarily, they participate in the regulation of the Th1 immune response, which is essential for the control of several intracellular infections, such as toxoplasmosis. This disease is associated with congenital infection, en
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-11
-
2. Translational realistic expectations of chronic cerebral hypoxemia in rat model after bilateral commom carotid artery ligation. Neurocognitive aspects
PURPOSE: To evaluate the effects of chronic cerebral hypoxia on memory of rats submitted to bilateral common carotid artery ligation (BCCL). METHODS: Every each week, for 16 weeks, 31 rats were tested for memory using a water and land mazes and compared with 30 normal rats (control group A). The variables were expressed by their mean and standard error
Acta Cir. Bras.. Publicado em: 2014-01
-
3. Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients
Objective: To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU). Methods: The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100β and neuron-specific enolase (NSE) were determined by ELISA. Results: Acute Physiologic
Rev. Bras. Psiquiatr.. Publicado em: 2013-09
-
4. The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate
Permanent bilateral occlusion of the common carotid arteries (2VO) in the rat has been established as a valid experimental model to investigate the effects of chronic cerebral hypoperfusion on cognitive function and neurodegenerative processes. Our aim was to compare the cognitive and morphological outcomes following the standard 2VO procedure, in which ther
Publicado em: 2011
-
5. O uso de células-tronco adultas em modelos experimentais de crises convulsivas. / The use of adult stem cells in experimental models of seizures.
In Brazil, it is estimated that epilepsy affects from 2% of the population, about three million people at different ages and social classes. The use of antiepileptic drugs is the most common form of seizure control, although about 50- 70% of patients with epilepsy are refractory to medication. Because of difficulties in finding effective treatments, it is cr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/05/2010
-
6. The modified 2VO ischemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate
Permanent bilateral occlusion of the common carotid arteries (2VO) in the rat has been established as a valid experimental model to investigate the effects of chronic cerebral hypoperfusion on cognitive function and neurodegenerative processes. Our aim was to compare the cognitive and morphological outcomes following the standard 2VO procedure, in which ther
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-12
-
7. Metabolic Approach to Evaluate Neuroprotection Promoted by A1 Adenosine Agonist in Pilocarpine-induced Epilepsy. / Abordagem Metabólica na Avaliação da Neuroproteção Promovida pelo Agonista Adenosinérgico A1 no Modelo de Epilepsia Induzida por Pilocarpina.
It is well known that the mismatch between local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) are frequently associated with seizure-induced neuronal damage in adult animal. This study was performed to verify if the neuroprotective effect of adenosinergic A1 receptor agonist R-Pia injected prior to pilocarpine could modulate LCGU
Publicado em: 2009
-
8. Stress-induced neuroinflammation: mechanisms and new pharmacological targets
Stress is triggered by numerous unexpected environmental, social or pathological stimuli occurring during the life of animals, including humans, which determine changes in all of their systems. Although acute stress is essential for survival, chronic, long-lasting stress can be detrimental. In this review, we present data supporting the hypothesis that stres
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-12
-
9. Disseleneto de difenila: Um organocalcogênio com baixa toxicidade em não roedores e importantes propriedades anti-aterogênicas em modelos in vivo e in vitro / Diphenyl Diselenide: an organoselenium compound with low toxicity in non rodents and importants antiatheorgenic properties
Atherosclerosis is a chronic inflammatory condition associated with an overproduction of oxidant species. Since low density lipoprotein (LDL) oxidation plays a key role in the pathogenesis of atherosclerosis, antioxidants that can inhibit this oxidative process might be useful in preventing atherosclerosis-related pathological conditions, such as cardiovascu
Publicado em: 2007
-
10. Aspectos do envelhecimento cerebral e função cognitiva em modelo experimental animal e estudo de mecanismos de neurodegeneração em cultura celular
The two phenomena, biological and behavioural, approached in the present work are brain aging and spatial memory. Several studies, comparative and experimental, have shown that aged subjects present significantly impaired performances in different types of cognitive tasks. It is also known that contradictions in literature exist in relation to consequences o
Publicado em: 2007
-
11. AVALIAÇÃO DE INDICADORES DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA ACETILCOLINESTERASE SANGÜÍNEA EM PACIENTES COM DIAGNÓSTICO DE ACIDENTE VASCULAR CEREBRAL ISQUÊMICO / AVALIATION OF MARKERS OF OXIDATIVE STRESS AND OF ENZYME ACETYLCHOLINESTERASE IN WHOLE BLOOD FROM PATIENTS DIAGNOSED WITH ISCHEMIC STROKE
In ischemic stroke, damage to the brain is caused by a reduction or complete blockage of blood flow to parts of the brain, resulting in glucose and oxygen deficiency. It is a leading cause of mortality and disability particularly in the elderly. The majority of strokes are not fatal and survivors are at a high risk of subsequent vascular complications and ne
Publicado em: 2006
-
12. Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy
Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry. More than 600 antiviral monoclonal antibodies generated against 11 different viruses have been reported to react with
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-02