Boron Neutron Capture Therapy
Mostrando 1-12 de 25 artigos, teses e dissertações.
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1. Os dados nucleares da Agência Internacional de Energia Atômica (IAEA) como aporte científico no Ensino de Física Nuclear
Resumo Neste artigo, é apresentada uma sugestão de atividade de ensino de Física Nuclear, na qual são utilizados dados nucleares da Agência Internacional de Energia Atômica (IAEA), tendo como eixo motivador a compreensão da física da Terapia por Captura de Nêutrons pelo Boro (BNCT). A fissão nuclear induzida por nêutrons, da reação 5 1
Rev. Bras. Ensino Fís.. Publicado em: 30/09/2019
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2. Confecção e calibração de filmes finos de boro para medida da taxa de reação 10B(n,alfa)7 Li na terapia por captura de nêutrons pelo boro / Manufacturing and calibration of boron thin films for the 10B(n,alfa)7 Li reaction rate measurement in the boron neutron capture therapy
O princípio de funcionamento da Terapia por Captura de Nêutrons pelo Boro (BNCT, Boron Neutron Capture Therapy) é a entrega seletiva de uma maior quantidade de átomos de boro às células cancerígenas do que àquelas saudáveis, seguida da irradiação com nêutrons que irá induzir a emissão de partículas a e íons de recuo de 7Li através da reaçã
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/03/2012
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3. Simulação Monte Carlo em terapia de câncer por captura de nêutrons pelo boro (BNCT) utilizando a plataforma GEANT4
Neste trabalho, foi utilizado a plataforma de simulação GEANT4 (Geometry and Tracking) para se avaliar a possibilidade de tratamento de esMago com a BNCT (BNCT em inglês, Boron Neutron Capture Therapy), sendo analisada a deposição de energia nas regiões que circundam o esMago. Como o trabalho apresentado é uma parte de um conjunto de estudos e pesquis
Publicado em: 2009
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4. Caracterização do campo de nêutrons na instalação para estudo em BNCT no Reator IEA-R1 / NEUTRON FIELD CHARACTERIZATION IN THE INSTALLATION FOR BNCT STUDY IN THE IEA R1 REACTOR.
This work aims to characterize the mixed neutron and gamma field, in the sample irradiation position, in a research installation for Boron Neutron Capture Therapy (BNCT), in the IPEN IEA-R1 reactor. The BNCT technique has been studied as a safe and selective option in the treatment of resistant cancerigenous tumors or considered non-curable by the convention
Publicado em: 2008
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5. Development of a tomographic system for online dose measurements in BNCT (Boron Neutron Capture Therapy)
Within our activities on accelerator-based boron neutron capture therapy (BNCT) carried out at the Tandar Laboratory (Comisión Nacional de Energía Atómica, Argentina) we present here the study and design of a tomographic imaging system for the measurement of the spatial distribution of the absorbed dose during a BNCT session. The 10B (n,alpha) 7Li boron n
Brazilian Journal of Physics. Publicado em: 2005-09
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6. Study of neutron-DNA interaction at the IPEN BNCT research facility
Our group at the Laboratorio do Acelerador Linear (IFUSP- USP) is currently developing several studies related to the interaction of different kinds of radiation with DNA. Initially, our plan is to study the interactions proton-DNA, gamma-DNA and neutron-DNA. In this work we describe the most important features of the neutron-DNA study, which we plan to perf
Brazilian Journal of Physics. Publicado em: 2004-09
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7. Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors.
Borocaptate sodium (Na2B12H11SH) is a boron-carrying compound under consideration for use in boron neutron capture therapy. The biodistribution of boron from borocaptate sodium administration will partly determine boron neutron capture therapy efficacy and normal tissue radiation tolerance. The biodistribution of boron was determined in 30 dogs with spontane
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8. Homogeneous immunoconjugates for boron neutron-capture therapy: Design, synthesis, and preliminary characterization
The application of immunoprotein-based targeting strategies to the boron neutron-capture therapy of cancer poses an exceptional challenge, because viable boron neutron-capture therapy by this method will require the efficient delivery of 103 boron-10 atoms by each antigen-binding protein. Our recent investigations in this area have been focused on the develo
The National Academy of Sciences.
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9. Model studies directed toward the application of boron neutron capture therapy to rheumatoid arthritis: Boron delivery by liposomes in rat collagen-induced arthritis
The application of boron neutron capture therapy to rheumatoid arthritis requires the selective delivery of the boron-10 isotope to the synovitic tissue. The use of liposomes as a boron delivery method has been explored through the measurement of the time course biodistribution of boron in rats with collagen-induced arthritis (CIA). Small unilamellar vesicle
The National Academy of Sciences.
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10. Neutron-capture therapy of human cancer: in vivo results on tumor localization of boron-10-labeled antibodies to carcinoembryonic antigen in the GW-39 tumor model system.
Antibody against carcinoembryonic antigen (CEA) was conjugated with p-[1,2-dicarba-closo-[1-3H]do-decaboran(12)-2-yl] benzenediazonium ion by an azo-coupling reaction, resulting in 30 boron atoms per IgG molecule with no loss of antibody protein. Antibody immunoreactivity was not appreciably affected by this conjugation and was stable after incubation in vit
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11. Synthesis and in vivo murine evaluation of Na4[1-(1′-B10H9)-6-SHB10H8] as a potential agent for boron neutron capture therapy
Reaction of the normal isomer of [B20H18]2− and the protected thiol anion, [SC(O)OC(CH3)3]−, produces an unexpected isomer of [B20H17SC(O)OC(CH3)3]4− directly and in good yield. The isomer produced under mild conditions is characterized by an apical–apical boron atom intercage connection as well as the location of the thiol substituent on an equatori
The National Academy of Sciences.
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12. Toward a cancer therapy with boron-rich oligomeric phosphate diesters that target the cell nucleus
The viability of boron neutron capture therapy depends on the development of tumor-targeting agents that contain large numbers of boron-10 (10B) atoms and are readily taken up by cells. Here we report on the selective uptake of homogeneous fluorescein-labeled nido-carboranyl oligomeric phosphate diesters (nido-OPDs) by the cell nucleus and their long-term re
The National Academy of Sciences.