Biotransformation
Mostrando 13-24 de 296 artigos, teses e dissertações.
-
13. Ligninolytic fungus Polyporus sp. S133 mediated metabolic degradation of fluorene
ABSTRACT This study aimed to investigate the impact of nonionic surfactants on the efficacy of fluorine degradation by Polyporus sp. S133 in a liquid culture. Fluorene was observed to be degraded in its entirety by Polyporus sp. S133 subsequent to a 23-day incubation period. The fastest cell growth rate was observed in the initial 7 days in the culture that
Braz. J. Microbiol.. Publicado em: 2016-09
-
14. Entendendo o processo químico de bioativação da sinvastatina por métodos experimentais e computacionais: uma aula prática
Cholesterol is a lipid which in high concentration can be an important risk factor for coronary diseases and atherosclerotic lesions. This lipid presents an endogenous biosynthesis that involves several steps; one of them is modulated by the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase). HMG-CoA reductase is inhibited by statins,
Quím. Nova. Publicado em: 2016-05
-
15. Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation
ABSTRACT The aim of this study was to characterize the mechanism of toxicity of fipronil on hepatocytes isolated from the rat and the effect of its biotransformation on the toxicological potential. The toxicity of fipronil was assessed by monitoring the oxygen consumption and mitochondrial membrane potential, intracellular ATP concentration, Ca2+ homeostasis
Braz. arch. biol. technol.. Publicado em: 2015-12
-
16. Metabolite variability in Caribbean sponges of the genus Aplysina
Abstract Sponges of the genus Aplysina are among the most common benthic animals on reefs of the Caribbean, and display a wide diversity of morphologies and colors. Tissues of these sponges lack mineralized skeletal elements, but contain a dense spongin skeleton and an elaborate series of tyrosine-derived brominated alkaloid metabolites that function as chem
Rev. bras. farmacogn.. Publicado em: 2015-12
-
17. Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid
ABSTRACTThe genus Erythrina, Fabaceae, is widely distributed in tropical and subtropical regions. Their flowers, fruits, seeds and bark are frequently used in folk medicine for its effects on the central nervous system such as anticonvulsant, antidepressant, analgesic, sedative, and hypnotic effects. Erythraline has been reported as one of the active compoun
Rev. bras. farmacogn.. Publicado em: 2015-10
-
18. Coupling DLLME-CE for the Stereoselective Analysis of Venlafaxine and Its Main Metabolites after Biotransformation by Fungi
Fungal biotransformations have become very important in the study of chiral drugs because the reactions performed by these microorganisms may be enantioselective. However, analyses of analytes present in liquid culture medium have proved to be very difficult due to the complexity of this matrix. The aim of this work was to couple dispersive liquid-liquid mic
J. Braz. Chem. Soc.. Publicado em: 2015-09
-
19. Efficacy of fungal decolorization of a mixture of dyes belonging to different classes
Dyes are the most difficult constituents to remove by conventional biological wastewater treatment. Colored wastewater is mainly eliminated by physical and chemical procedures, which are very expensive and have drawbacks. Therefore, the advantage of using biological processes, such as the biotransformation of dyes, is that they may lead to complete mineraliz
Braz. J. Microbiol.. Publicado em: 2015-06
-
20. Biotransformation of the Diterpene Ent-18,19-dihydroxytrachylobane by Rhizopus stolonifer
The diterpene ent-18,19-dihydroxytrachylobane was biotransformed for the first time by Rhizopus stolonifer, and yielded the new ent-11β,18,19-trihydroxytrachylobane derivative besides the new ent-kaur-11-ene diterpenes ent-16α,18,19-trihydroxykaur-11-ene and ent-18,19-dihydroxy-16α-methoxykaur-11-ene. Their structures were determined by spectrometric meth
J. Braz. Chem. Soc.. Publicado em: 2015-05
-
21. Biomarkers of oxidative stress and acetylcholinesterase activity in the blood of grass snake (Natrix natrix L.) during prehibernation and posthibernation periods
This work examined the enzymatic (superoxide dismutase-CuZn SOD, catalase-CAT, glutathione peroxidase-GSHPx, glutathione reductase-GR, and the biotransformation phase II enzyme glutathione-S-transferase-GST) and nonenzymatic (total glutathione-GSH and lipid peroxides-TBARS concentrations) biomarkers of oxidative stress and acetylcholinesterase (AChE) activit
Braz. arch. biol. technol.. Publicado em: 06/03/2015
-
22. Hydroxylation of 1,8-cineole by Mucor ramannianusand Aspergillus niger
The monoterpenoid 1,8-cineole is obtained from the leaves of Eucalyptus globulus and it has important biological activities. It is a cheap natural substrate because it is a by-product of the Eucalyptuscultivation for wood and pulp production. In this study, it was evaluated the potential of three filamentous fungi in the biotransformation of 1,8-cineole. The
Braz. J. Microbiol.. Publicado em: 2015-03
-
23. Biotransformation of Tributyltin chloride by Pseudomonas stutzeri strain DN2
A bacterial isolate capable of utilizing tributyltin chloride (TBTCl) as sole carbon source was isolated from estuarine sediments of west coast of India and identified as Pseudomonas stutzeri based on biochemical tests and Fatty acid methyl ester (FAME) analysis. This isolate was designated as strain DN2. Although this bacterial isolate could resist up to 3
Braz. J. Microbiol.. Publicado em: 2014-12
-
24. Microbial biotransformation of beclomethasone dipropionate by Aspergillus niger
Na pesquisa presente o fármaco esteróide antiasmático dipropionato de beclometasona foi submetido à biotransformação microbiana pelo Aspergillus niger. O dipropionato de beclometasona foi transformado, pela primeira vez, em metabólitos variados por biotransformação microbiana. Novos metabólitos do fármaco produzidos podem agir como novas molécula
Braz. J. Pharm. Sci.. Publicado em: 2014-12