Biomolecules Damage
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Nicotine as a Catalyst for Chlorination Promoted by Hypochlorous Acid: Experimental and Theoretical Studies
There is robust evidence of the hypochlorous acid (HClO)-mediated damage in biomolecules, and nicotine boosts the chlorination potency of HClO. We present experimental and theoretical evidence of the mechanism by which nicotine catalyzes the chlorination of pyranine. The rate constants for chlorination of pyranine by HClO were measured in the presence (5.3 �
Journal of the Brazilian Chemical Society. Publicado em: 2023
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2. Biochemistry and Renal Function: Use of Inquiry-Based Teaching Sequences for Retrieval of Specific Concepts
RESUMO As propostas de ensino atuais envolvem estratégias de ensino que auxiliam e incentivam a construção do conhecimento, fazendo com que o aluno seja um participante ativo do processo de aprendizagem, e têm sido alvo de diversas pesquisas. Este artigo relata, aula a aula, uma sequência didática realizada com alunos em fase inicial de formação, apl
Rev. bras. educ. med.. Publicado em: 13/01/2020
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3. The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females
Abstract Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed to investigate
Genet. Mol. Biol.. Publicado em: 29/11/2018
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4. Xanthine oxidase activity in patients with age-related cataract associated with hypertension
Reactive oxygen species and lipid peroxidation are important factors that contribute to the development of age-related cataract. The study included 130 patients with age-related cataract, 69 of whom were diagnosed with hypertension (HT), 20 with hypertension and type 2 diabetes mellitus (DM), and 41 had no accompanying condition. The following parameters wer
Braz J Med Biol Res. Publicado em: 26/03/2018
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5. Phenolic Content and Biomolecule Oxidation Protective Activity of Globularia alypum Extracts
ABSTRACT The protective activity of methanolic (Met E) and aqueous (Aq E) extracts of Globularia alypum L. (G. alypum) against DNA, lipid and protein oxidative damage was investigated. Moreover, the scavenging, chelating, and reducing power activities of the extracts were also evaluated. Phytochemical analysis was performed to determine phenolic compounds. R
Braz. arch. biol. technol.. Publicado em: 17/08/2017
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6. Danos oxidativos promovidos por espécies de Mn(III) sobre biomoléculas e células em situação de estresse / Oxidative damage induced by Mn(III) species over biomolecules and stressed cells
Manganese is an essential trace element, however there is considerable concern regarding its neurological effects when in excess, giving rise to a condition termed manganism which is characterized by Parkinson disease-like symptoms. Most evaluations of manganese toxicity use poorly defined Mn(II) species, although Mn(III) is known to accumulate preferentiall
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/03/2012
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7. Investigação de parâmetros de estresse oxidativo e inflamação em pacientes com doença de Fabry submetidos à terapia de reposição enzimática : correlações com globotriaosilceramida
Fabry disease (FD) is an X-linked inborn error of glycosphingolipid catabolism due to deficient activity of C-galactosidase A. Patients present as main findings angiokeratomas in skin and acroparesthesias and usually die in adult age of renal failure and stroke. As a consequence of the enzyme deficiency, the substrates (mainly globotriaosylceramide - Gb3) ac
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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8. Hidroperóxidos de lipídios como fontes de oxigênio molecular singlete (O2 [1Δg]), detecção e danos em biomoléculas / Lipid hidroperoxides as singlet molecular oxygen precursors (O2 [1Δg]), detection and damage to biomolecules
O estudo do processo da peroxidação de lipídios tem aumentado nos últimos anos, principalmente devido à implicação dos hidroperóxidos de lipídios (LOOH) em diversos processos patológicos. A decomposição destes LOOH é capaz de gerar subprodutos capazes de promover danos em biomoléculas, incluindo proteínas e DNA. No presente trabalho, utilizand
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/07/2011
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9. Pro- and antiinflammatory cytokines in steatohepatitis: what profile in moderate obesity with diabetes? / Marcadores inflamatórios sistêmicos em pacientes com doença hepática gordurosa não alcoólica (DHGNA)
Background: Fatty liver disease is a problem of obesity in the morbid modality and even more so in nonbariatric candidates, who rely on clinical treatment only. TNF- has been frequently measured in steatohepatitis (NASH) with or without diabetes, but less in known about IL-6 and IL-10. Methods: Moderately obese patients (n=80) with histologically proven Stea
Publicado em: 2010
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10. Investigação da atividade biológica de complexos de cobre(II) com ligantes inspirados em biomoléculas / Investigations on the biological activity of copper(II) complexes with ligands inspired in biomolecules
Neste trabalho, alguns novos complexos imínicos de cobre(II) com ligantes inspirados em biomoléculas como oxindóis, contendo grupos indólicos, imidazólicos ou pirrólicos com diferentes características estruturais, foram sintetizados e caracterizados por análise elementar, espectrometria ESI-MS e espectroscopias IV, UVNis e EPR. As possíveis interaç
Publicado em: 2009
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11. Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: principais métodos analíticos para sua determinação
We review here the chemistry of reactive oxygen and nitrogen species, their biological sources and targets; particularly, biomolecules implicated in the redox balance of the human blood, and appraise the analytical methods available for their detection and quantification. Those biomolecules are represented by the enzymatic antioxidant defense machinery, wher
Química Nova. Publicado em: 2007-10
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12. Investigação de lesões em DNA induzidas pelo hidrocarboneto policíclico aromático antantreno / Investigation of DNA damage induced by polycyclic aromatic hydrocarbon anthanthrene.
Anthanthrene is a polycyclic aromatic hydrocarbon (PAH) widely spread in the environment and does not have the bay or fjord regions, which in general provide high reactivity to these compounds after oxidation. However, its mutagenic activity to bacteria after metabolic activation is comparable to that of benzopyrene (BP) and, based on the sensitivity of the
Publicado em: 2007