Biological Therapy
Mostrando 1-12 de 328 artigos, teses e dissertações.
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1. Quais as indicações para a eletroconvulsoterapia (ECT)?
A eletroconvulsoterapia (ECT) é um tratamento biológico que a partir de uma convulsão induzida propõe benefícios terapêuticos para alguns quadros de transtornos psiquiátricos. Os avanços na anestesia e equipamentos de estimulação elétrica, a utilização de eletrodos e as formas de pulso melhoraram os efeitos colaterais e a segurança no tratam
Núcleo de Telessaúde Minas Gerais - NUTEL. Publicado em: 12/06/2023
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2. Stem cell therapy as a potential treatment option for psoriasis
Abstract Psoriasis is a chronic inflammatory dermatological disorder characterized by white scales and clearly demarcated erythematous plaques. The prevalence of psoriasis varies from country to country and can occur at any age, implying that ethnicity, environmental factors, and genetic background all play a role in its onset. According to the World Psorias
Anais Brasileiros de Dermatologia. Publicado em: 2022
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3. Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes
This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of their ability to inhibit some in vitro (coagulant, proteolytic and hemolytic) and in vivo (hemorrhagic, edematogenic and lethality) toxic activities of Bothrops jararaca and Bothrops jararacussu venoms. Compounds have been synthesized from the coupling of intermedi
Journal of the Brazilian Chemical Society. Publicado em: 2022
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4. New treatments for rare bone diseases: hypophosphatemic rickets/osteomalacia
Abstract Phosphorus is one of the most abundant minerals in the human body; it is required to maintain bone integrity and mineralization, in addition to other biological processes. Phosphorus is regulated by parathyroid hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], and fibroblast growth factor 23 (FGF-23) in a complex set of processes that occur in the gu
Archives of Endocrinology and Metabolism. Publicado em: 2022
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5. Natural and Semisynthetic Triterpenes from Combretum leprosum Mart. with Antiplasmodial Activity
Malaria is responsible for thousands of deaths each year. Currently, artemisinin combination therapy (ACT) is used as first-choice medication against the disease. However, the emergence of resistant strains prompts the search for alternative compounds. The present study aimed to investigate the antiplasmodial activities of natural triterpenes (compounds 1 an
Journal of the Brazilian Chemical Society. Publicado em: 2022
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6. The Effect of Dialectic Behavioral Counseling on Depression, Anxiety, and Postpartum Hematocrit Level
Abstract Objective Childbirth is a biological, psychological, and sociological event that can be a positive or negative experience, and, without support, this period may be potentially damaging. Parturition may distort maternal emotions and lead to short- or long-term disorders such as postpartum depression and anxiety. The present research aims to study t
Rev. Bras. Ginecol. Obstet.. Publicado em: 2021-04
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7. Follow-up and outcome of the twelve-year experience in adult patients with acute promyelocytic leukemia
ABSTRACT Acute promyelocytic leukemia is a subtype of acute myeloid leukemia, characterized by the presence of neoplastic promyelocytes, due to the reciprocal balanced translocation between chromosomes 15 and 17. Currently, with the use of agents that act directly on this molecular change, such as all-trans retinoic acid and arsenic trioxide, APL has shifted
Hematol., Transfus. Cell Ther.. Publicado em: 2021-03
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8. BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
Objective: Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism’s moderation effect on resilience scores in response to cognitive therapy. Method: A
Braz. J. Psychiatry. Publicado em: 2021-02
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9. Synthesis, Characterization, Spectroelectrochemical, Photophysical and HSA-Binding Properties of Novel and Versatile meso-Tetra(4-pyridylvinylphenyl)porphyrins Coordinated to Ruthenium(II)-Polypyridyl Derivatives
The free-base meso-tetra(4-pyridylvinylphenyl)porphyrin (1a) and its zinc(II) complex were synthesized and then functionalized with [Ru(bpy)2Cl]+ units (2a and 2b) via conventional methods and evaluated in terms of photophysical, electrochemical and biological aspects. All porphyrins present moderate singlet oxygen production and fluorescence quantum yield,
J. Braz. Chem. Soc.. Publicado em: 2020-11
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10. Self-Assembled Nanoparticles of Diruthenium(II,III)-Ibuprofen Anticancer Metallodrug
The diruthenium(II,III)-ibuprofen (RuIbp) metallodrug shows anticancer activity in vitro and in vivo. The encapsulation into lipid nanoparticles enhanced the efficacy in glioblastoma, breast and prostate cancer cells. Here we report data for RuIbp hydrophobicity, solubility in alcohol/water, and behavior in 1-5% ethanol/water and ethanol/cell culture medium.
J. Braz. Chem. Soc.. Publicado em: 2020-11
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11. Spitz nevus and infliximab: association or coincidence?,
Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the ca
An. Bras. Dermatol.. Publicado em: 2020-10
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12. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain
Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcranial magne
Braz. J. Psychiatry. Publicado em: 2020-08