Biological Response Modulators
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Metodologia otimizada para extração da B-glucana de Saccharomyces cerevisiae e avaliação do potencial imunomodulador e antigenotóxico em pacientes com câncer de próstata avançado
No presente estudo uma metodologia otimizada foi desenvolvida para extração da β-glucana de células de Saccharomyces cerevisiae , envolvendo sonicação e tratamento enzimático, com rendimento de 11,08 ± 0,19 %. A partir da β-glucana extraída foi obtido o carboximetilderivado correspondente, que não mostrou, in vitro, quaisquer efeitos citot
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/08/2010
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2. Characterization of environmental regulators of Bordetella pertussis.
Bordetella pertussis suppresses transcription of its virulence genes in response to specific environmental conditions, a response called modulation. The organism responds to high concentrations of SO4 and CIO4 ions, nicotinic acid, and nicotinic acid analogs in vitro; however, the in vivo modulator has not been identified. We investigated which chemical stru
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3. Estradiol and Tamoxifen Mediate Rescue of the Dominant-Negative Effects of Estrogen Response Element-Binding Protein in Vivo and in Vitro
Biological responses to estrogens are dependent on the integrated actions of proteins, including the estrogen receptor (ER)-α, that regulate the transcription of estrogen response element (ERE)-containing target genes. We have identified a naturally occurring ERE antagonist, termed an ERE-binding protein (BP). To verify that ERE-BP can induce estradiol (E2)
The Endocrine Society.
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4. Submicrosecond pacemaker precision is behaviorally modulated: The gymnotiform electromotor pathway
What are the limits and modulators of neural precision? We address this question in the most regular biological oscillator known, the electric organ command nucleus in the brainstem of wave-type gymnotiform fish. These fish produce an oscillating electric field, the electric organ discharge (EOD), used in electrolocation and communication. We show here that
The National Academy of Sciences.
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5. Expression of the murine interleukin-4 gene in an attenuated aroA strain of Salmonella typhimurium: persistence and immune response in BALB/c mice and susceptibility to macrophage killing.
Cytokines are potentially useful in vaccination as adjuvants or modulators of the type of response induced. The work below describes the expression of a cloned cytokine gene for murine interleukin-4 (mIL-4) by a live vaccine vector, an attenuated aroA strain (SL7207) of Salmonella typhimurium, in a murine model system. SL7207 was used as a carrier for two di
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6. Dehydration-responsive Nuclear Proteome of Rice (Oryza sativa L.) Illustrates Protein Network, Novel Regulators of Cellular Adaptation, and Evolutionary Perspective*
Water deficit or dehydration is the most crucial environmental constraint on plant growth and development and crop productivity. It has been postulated that plants respond and adapt to dehydration by altering their cellular metabolism and by activating various defense machineries. The nucleus, the regulatory hub of the eukaryotic cell, is a dynamic system an
The American Society for Biochemistry and Molecular Biology.
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7. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype
One of the striking features of vascular endothelium, the single-cell-thick lining of the cardiovascular system, is its phenotypic plasticity. Various pathophysiologic factors, such as cytokines, growth factors, hormones, and metabolic products, can modulate its functional phenotype in health and disease. In addition to these humoral stimuli, endothelia
The National Academy of Sciences.
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8. A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.
Successful recovery from DNA damage requires coordination of several biological processes. Eukaryotic cell cycle progression is delayed when the cells encounter DNA-damaging agents. This cell cycle delay allows the cells to cope with DNA damage by utilizing DNA repair enzymes. Thus, at least two processes, induction of the cell cycle delay and repair of dama
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9. Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis because of the complexity of AD and the overlap of its early-stage markers with normal aging. Gene microarrays provide new tools for addressing complexity because they allow overviews of the simultaneous activity of multiple cellular pathways. However, microarray data inter
National Academy of Sciences.