Biologic Therapies
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. O que é Psoríase Inversa?
A psoríase inversa é uma forma rara de psoríase que afeta entre 3% e 7% dos pacientes com psoríase (
). Atinge principalmente áreas úmidas, menos visíveis (
). Caracteriza-se por lesões nas grandes pregas cutâneas, em particular nas regiões inframamária, interglútea, perineal e axilar, que são eritematosas, brilhantes e com pouca
Núcleo de Telessaúde Sergipe. Publicado em: 12/06/2023
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2. Use of tumor necrosis factor alpha (TNF α) antagonists in a patient with psoriasis and Chagas disease
AbstractThere are several studies on the benefits of using TNFα antagonists in the treatment of psoriasis, but few studies addressing the interaction of these drugs with chronic infections. We report the case of a 52-year-old patient diagnosed with psoriasis refractory to traditional systemic agents, who was treated with biologic therapies. After one year o
An. Bras. Dermatol.. Publicado em: 2015-06
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3. Biologic therapy for psoriasis - still searching for the best target
Psoriasis is a chronic skin disease that results from the complex interaction between genetic and environmental factors. Over the last few decades, scientific evidence has redirected the focus of therapeutic studies to the immunologic pathways underlying its pathogenesis. This led to the biologic boom that we are currently experiencing, with the development
An. Bras. Dermatol.. Publicado em: 2014-04
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4. The impact of glucocorticoids and anti-cd20 therapy on cervical human papillomavirus infection risk in women with systemic lupus erythematosus
OBJECTIVE: To identify the prevalence and factors associated with cervical human papillomavirus infection in women with systemic lupus erythematosus METHODS: This cross-sectional study collected traditional and systemic lupus erythematosus-related disease risk factors, including conventional and biologic therapies. A gynecological evaluation and cervical
Clinics. Publicado em: 2013-12
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5. Avaliação do uso de terapias biológicas em pacientes com artrite reumatoide no Estado de Mato Grosso, Brasil / Evaluation of the use of biologic therapies in patients with rheumatoid arthritis in the State of Mato Grosso, Brazil
A artrite reumatoide é doença autoimune, debilitante, com graves consequências físicas, econômicas e emocionais, que afeta cerca de 0,5 a 1% da população adulta mundial. Avanços significativos no reconhecimento da fisiopatologia da doença e mecanismos de lesão permitiram desenvolvimento de novas opções de tratamento através de medicamentos que b
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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6. T-Cell Lymphomas in South America and Europe
Peripheral T-cell lymphomas are a group of rare neoplasms originating from clonal proliferation of mature post-thymic lymphocytes with different entities having specific biological characteristics and clinical features. As natural killer cells are closely related to T-cells, natural killer-cell lymphomas are also part of the group. The current World Health O
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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7. Plasmablastic multiple myeloma is associated with increased vascular endothelial growth factor immunoexpression
The biologic basis of the negative prognosis of plasmablastic myeloma is not fully understood. To determine whether histologically aggressive multiple myeloma (MM) is associated with a more angiogenic marrow environment, bone marrow samples from 50 recently diagnosed MM patients were evaluated. Twelve percent (6/50) of patients presented plasmablastic MM, an
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-11
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8. Monoclonal antibodies and other biologic agents in the treatment of asthma
Asthma represents a syndrome of airway inflammatory diseases with complex pathology. The immunologic pathogenesis is being increasingly revealed and provides opportunity for targeted biological intervention. Current experience with immunomodulators as targeted therapy in asthma is described in this literature review. Targeted therapies have included strategi
Landes Bioscience.
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9. Tissue engineering and cell based therapies, from the bench to the clinic: The potential to replace, repair and regenerate
The field of Regenerative Biology as it applies to Regenerative Medicine is an increasingly expanding area of research with hopes of providing therapeutic treatments for diseases and/or injuries that conventional medicines and even new biologic drug therapies cannot effectively treat. Extensive research in the area of Regenerative Medicine is focused on the
BioMed Central.
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10. Tetracycline-regulated cardiac gene expression in vivo.
Tight regulation of foreign genes expressed in vivo would facilitate studies of many biologic processes and would be useful for gene transfer-based therapies. To test the ability of a tetracycline-regulated gene expression system to function in vivo, we directly injected chimeric tet repressor-VP16 transactivator expression plasmids and luciferase target gen
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11. Clinical Trials For Cytoprotection In Stroke
Summary: To date, many cytoprotective drugs have reached the stage of pivotal phase 3 efficacy trials in acute stroke patients. (Table 1) Unfortunately, throughout the neuroprotective literature, the phrase “failure to demonstrate efficacy” prevails as a common thread among the many neutral or negative trials, despite the largely encouraging results enco
The American Society for Experimental NeuroTherapeutics.
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12. Role of steroids and immunosuppression and effects of interferon beta-1b in multiple sclerosis.
Corticosteroids, corticotropin, azathioprine, cyclophosphamide, and IFN-beta 1b have each had a substantial effect on the care of patients with multiple sclerosis and the design of subsequent clinical trials of experimental therapeutics for MS. The use of MRI scanning and more sensitive clinical outcome measures will possibly enable us to complete clinical t