Bioinorganic Chemistry
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Manganês: o papel do fracionamento químico e da especiação como determinantes de seu comportamento geoquímico e neurotóxico nos organismos em desenvolvimento / Manganese: role of chemical fractioning and speciation as determinants of its geochemical and developmental neurotoxicological effect
O manganês (Mn) é um elemento essencial, porém pode ser tóxico em concentrações acima do requerido fisiologicamente. Assim, motivado pelo aumento nos teores desse metal na bacia hidrográfica Alto do Paranapanema (ALPA) e o crescente número de estudos internacionais relacionando desordens neurológicas ao excesso de Mn em águas superficiais, o presen
Publicado em: 2009
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2. InvestigaÃÃo da Atividade de Complexos InorgÃnicos Inibidores da trans-2-enoil redutase / Research Activity of the Complex Inorganic inhibitors trans-2-enoyl reductase
A tuberculose tem sido uma das principais causas de morte no Mundo. Infelizmente, nÃo existem ainda novas drogas disponÃveis, o que tem desestimulado a investigaÃÃo neste campo. Neste trabalho, preparou-se novos metalo-compostos baseado no sistema Na3[Fe(CN)5L].H2O, sendo L = oxadiazois, hidrazonas ou derivados, que sÃo drogas estudas no tratamento para
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/04/2008
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3. Uma visão da química bioinorgânica medicinal
Metals play a vital role in human and plant physiology and important research is directed towards exploring the interrelated mechanisms that govern their interactions with biomolecules. Bioinorganic medicinal chemistry studies the functions, processing, storage and applications of metal ions and their complexes in biological systems. This paper presents a br
Química Nova. Publicado em: 2007
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4. Construção de campo de força empírico para estudo de complexos de Fe(III) com interesse bioinorgânico
In this work we present a new parametrization in molecular mechanics for studying iron complexes. This force field was implemented in the FORCES 2000 program, developed in our group for studying in coordination compounds of interest in bioinorganic chemistry. Mononuclear and dinuclear iron complexes were studied using this program with good success.
Química Nova. Publicado em: 2006-04
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5. Estudo de complexos polimetalados contendo espécies biologicamente Ativas de rutênio/dirutênio" / Study of polynuclear metal complexes containing biologically active ruthenium/diruthenium units
Os complexos de rutênio há algumas décadas são estudados visando à aplicação em medicina, catálise e fotoquímica. Particularmente, com interesse voltado para a área médica, novos compostos têm sido desenvolvidos para substituir a cis-platina no tratamento do câncer, uma vez que este medicamento atua numa gama restrita de tipos de tumores e apres
Publicado em: 2005
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6. Reatividade e implicações em processos biológicos de complexos imínicos de cobre(II) / Reactivity and implications in biological processes of imine-copper(II) complexes
Neste trabalho sintetizaram-se novos complexos imínicos e diimínicos de Cu(II) derivados da isatina, um indol endógeno, que foram então extensivamente caracterizados por análise elementar, medidas de condutividade molar, técnicas espectroscópicas: IV, UV/Vis e EPR, e por espectrometria de massa, ESI-MS. Estes compostos apresentaram equilíbrio ceto-en
Publicado em: 2005
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7. Bioinorganic chemistry in the postgenomic era
Genome sequencing has revolutionized all fields of life sciences. Bioinorganic chemistry is certainly not immune to this influence, which is presenting unprecedented challenges. A new goal for bioinorganic chemistry is the investigation of the linkages between inorganic elements and genomic information. This requires new advancements and/or the development o
The National Academy of Sciences.
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8. The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies
The bioinorganic chemistry of iron is central to life processes. Organisms must recruit iron from their environment, control iron storage and trafficking within cells, assemble the complex, iron-containing redox cofactors of metalloproteins, and manage a myriad of biochemical transformations by those enzymes. The coordination chemistry and the variable oxida
The National Academy of Sciences.
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9. Biological inorganic chemistry at the beginning of the 21st century
Advances in bioinorganic chemistry since the 1970s have been driven by three factors: rapid determination of high-resolution structures of proteins and other biomolecules, utilization of powerful spectroscopic tools for studies of both structures and dynamics, and the widespread use of macromolecular engineering to create new biologically relevant structures
The National Academy of Sciences.
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10. Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry
This perspective discusses the ways that advanced paramagnetic resonance techniques, namely electron-nuclear double resonance (ENDOR) and electron spin-echo envelope modulation (ESEEM) spectroscopies, can help us understand how metal ions function in biological systems.
The National Academy of Sciences.
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11. Soft x-ray magnetic circular dichroism: a probe for studying paramagnetic bioinorganic systems.
Soft x-ray magnetic circular dichroism was used to study a paramagnetic bioinogranic system. We measured the Fe L edges of Pyrococcus furiosus rubredoxin, using circularly polarized synchrotron radiation, a split-coil super-conducting magnet, low sample temperatures, and fluorescence detection. The observed dichroism effect is strong (30%) and in general agr
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12. Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease
The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other neurodegenerative synucleinopathies. We demonstrate here that Cu(II) ions are effective in accelerating AS aggregation at physiologically relevant concentrations without altering the resultant fibrillar structures. By using numerous spectroscopic techniques (absorption, C
National Academy of Sciences.