Bioguided Fractionation
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Evaluation of Argentinean medicinal plants and isolation of their bioactive compounds as an alternative for the control of postharvest fruits phytopathogenic fungi
Abstract One of the main problems that fruit health goes through in recent years is the difficult eradication of their fungal pathogens after harvesting. This concern to the whole world because it represents huge losses of production, fruit export restrictions and consumers distrust. One of the alternatives to solve this problem could be the exploration of p
Rev. bras. farmacogn.. Publicado em: 09/12/2019
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2. Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria
Abstract Background Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected diseases. Therefore, the discovery of alternative drugs for treating chronic Chagas disease requires immediate acti
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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3. Bioactive Indole Alkaloids from Croton echioides
Bioguided fractionation of a hydroethanolic extract from the stem bark of Croton echioides Baill. led to isolation of the new indole alkaloid N-trans-feruloyl-3,5-dihydroxyindolin-2-one as a stereoisomeric mixture and the known alkaloids N-trans-p-coumaroyl-tryptamine, N-trans-p-coumaroyl-5-hydroxytryptamine, N-trans-4-methoxy-cinnamoyl-5-hydroxytryptamine,
J. Braz. Chem. Soc.. Publicado em: 2016-12
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4. Anesthetic activity and bio-guided fractionation of the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. in silver catfish Rhamdia quelen
Este trabalho tem como objetivo determinar a eficácia do óleo essencial deA. gratissima como anestésico para jundiás, bem como realizar o fracionamento bio-guiado do óleo essencial a fim de isolar os compostos responsáveis pelos efeitos observados. Os peixes foram submetidos ao banho-anestésico com óleo essencial, suas frações e compostos isolados
An. Acad. Bras. Ciênc.. Publicado em: 28/07/2015
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5. Antileishmanial and antitrypanosomal activity of the cutaneous secretion of Siphonops annulatus
Background Among the tropical parasitic diseases, those caused by protozoans are considered a challenge to public health, being represented by leishmaniasis and Chagas disease. In view of the low effectiveness and toxicity of the current therapy, animal venoms such as amphibian secretions have been used as a promising source of new drug prototypes. The pr
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/01/2015
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6. Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.
Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and E
Mem. Inst. Oswaldo Cruz. Publicado em: 16/01/2015
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7. Produção, isolamento e identificação de metabólito com atividade citotóxica de cultura de Streptomyces carpaticus / Production, isolation and identification of citotoxic activity metabolite of streptomyces carpaticus culture
This study addresses the production, isolation and identification of the substance present in culture broth of Streptomyces carpaticus which showed high biological activity against human tumor cell lines HL-60 (promyelocytic leukemia), MDA-MB 435 (breast carcinoma ), HCT-8 (colon carcinoma), SF-295 (glioblastoma). Cultures of Streptomyces carpaticus in cultu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/09/2011
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8. Bromopyrrole alkaloids from the caribbean sponge Agelas cerebrum
Bioguided fractionation of Agelas cerebrum crude extract resulted in isolation of four bromopyrrole and four bromopyrrole aminoimidazole alkaloids, identified as 5-bromopyrrole-2-carboxylic acid (1), 4-bromopyrrole-2-carboxylic acid (2), 3,4-bromopyrrole-2-carboxylic acid (3), 4,5-bromopyrrole-2-carboxylic acid (4), oroidin (5), bromoageliferin (6), dibromoa
Química Nova. Publicado em: 2011
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9. Prospecção e identificação de compostos bioativos de subprodutos agroindustriais / Prospecting and identifying bioactive compounds in agroindustrial byproducts
Atualmente, milhões de toneladas de subprodutos são produzidas durante o processamento de alimentos pelas agroindústrias. A maioria deles é rica em compostos bioativos, principalmente os fenólicos, os quais são responsáveis por várias atividades biológicas. Assim, este trabalho teve como objetivos avaliar o conteúdo de compostos fenólicos totais e
Publicado em: 2011
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10. Antimycobacterial neolignans isolated from Aristolochia taliscana
Tuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and therapeutic options for treatment are not always accessible;
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-02
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11. Constituents from Maytenus ilicifolia leaves and bioguided fractionation for gastroprotective activity
Maytenus ilicifolia Mart. ex Reissek é tradicionalmente usada no Brasil para o tratamento de úlcera gástrica. O presente trabalho relata a investigação fitoquímica de um extrato etanólico de folhas de M. ilicifolia (EEMIL) visando o isolamento de constituintes que foram usados como marcadores químicos para monitorar o fracionamento de um extrato aquo
Journal of the Brazilian Chemical Society. Publicado em: 2010
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12. VARIABILIDADE SAZONAL, ATIVIDADE ANTIMICROBIANA, FRACIONAMENTO BIO-GUIADO, ISOLAMENTO E ELUCIDAÇÃO ESTRURAL DOS PRINICPAIS CONSTITUINTES DO ÓLEO ESSENCIAL DE Lippia alba (MILL.) N. E. BROWN / SEASONAL VARIABILITY, ANTIMICROBIAL ACTIVITY, BIOGUIDED FRACTIONATION, ISOLATION AND STRUCTURAL ELUCIDATION OF THE MAIN CONSTITUENTS OF THE ESSENTIAL OIL OF Lippia alba (MILL.) N. E. BROWN
Lippia alba (Mill.) N. E. Brown é uma planta medicinal nativa da América do Sul. Conhecida popularmente como falsa-melissa, suas folhas e raízes são empregadas no tratamento de várias doenças, incluindo algumas de etiologia infecciosa. A presença dos óleos essenciais, entre outros metabólitos com reconhecida atividade antimicrobiana, pode explicar o
Publicado em: 2009