Biodistribution
Mostrando 1-12 de 121 artigos, teses e dissertações.
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1. Mesenchymal stem cell therapy in acute kidney injury (AKI): review and perspectives
SUMMARY INTRODUCTION: Acute kidney injury (AKI) is highly prevalent today. It has a multifactorial aetiology and affects people of all ages, genders and ethnicities. Its treatment is essentially supportive of renal function substitution, so new treatment alternatives such as mesenchymal stem cell therapy (MSCs) should be investigated. METHODS: This review
Rev. Assoc. Med. Bras.. Publicado em: 13/01/2020
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2. Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies
The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowab
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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3. SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES
Superparamagnetic iron oxide nanoparticles are suitable contrast agents for magnetic resonance imaging due to their effect on proton relaxation times, and excellent biocompatibility and biodistribution in tissue. In the present study, a ferrofluid formed by dextran-coated iron oxide nanoparticles was prepared by the coprecipitation method and with subsequent
Quím. Nova. Publicado em: 2019-01
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4. Clinical perspectives of PSMA PET/MRI for prostate cancer
Prostate cancer imaging has become an important diagnostic modality for tumor evaluation. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has been extensively studied, and the results are robust and promising. The advent of the PET/magnetic resonance imaging (MRI) has added morphofunctional information from the standard of refere
Clinics. Publicado em: 21/09/2018
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5. Perspectives of Dendrimer-based Nanoparticles in Cancer Therapy
Abstract Currently, cancer is the second most common cause of death in the United States, exceeded only by heart disease. Chemotherapy traditionally suffers from a non-specific distribution, with only a small fraction of the drug reaching the tumor, in this sense, the use of dendrimers incorporating drugs non-covalently encapsulated inside the dendrimer or c
An. Acad. Bras. Ciênc.. Publicado em: 26/07/2018
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6. Mercury Biodistribution in Rats after Chronic Exposure to Mercury Chloride
This study aimed to evaluate the distribution of mercury in rats after controlled chronic exposure to three different doses of HgCl2 for 30 days. Samples of blood, brain, liver, testis, heart, and kidneys were collected for mercury determination. Although the rats were exposed to different doses, the Hg levels in blood were similar among the groups under stu
J. Braz. Chem. Soc.. Publicado em: 2018-07
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7. Multiple Spectroscopic and Theoretical Approaches to Study the Interaction between HSA and the Antiparasitic Drugs: Benznidazole, Metronidazole, Nifurtimox and Megazol
The interaction between four antiparasitic drugs (benznidazole (BZL), metronidazole (MTZ), nifurtimox (NFX) and megazol (MZ)) with human serum albumin (HSA), the main vehicle of biodistribution of xenobiotics, hydrophobic, small and endogenous molecules in the bloodstream, was evaluated by multiple spectroscopic techniques and theoretical calculations. In al
J. Braz. Chem. Soc.. Publicado em: 2018-07
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8. Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats
ABSTRACT Quercetin has potent antioxidant action and a hepatoprotective role. The aim of this study was to evaluate the hepatoprotective action of quercetin pretreatment in paracetamol-induced liver damage (PILD) and structural injury resulting from partial hepatectomy (PH). In the first model, Wistar rats received oral quercetin (50mg/kg/day) during 8 days.
Braz. arch. biol. technol.. Publicado em: 11/05/2017
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9. In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats
ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by t
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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10. Oxacillin magnetically targeted for the treatment of Methicillin-Resistant S. aureus infection in rats
Abstract Purpose: To evaluate the effect of oxacillin bonded to magnetic nanoparticles in local infection model in rat. Methods: Twelve Wistar rats weighing 290±18g were randomly divided into four groups (n=6, each) and all rats had a magnet ring sutured on their right thighs. In the biodistribution group rats 0.1mL of 99mTc-magnetite (0.66 MBq) was injec
Acta Cir. Bras.. Publicado em: 2017-01
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11. Functional investigation of bone implant viability using radiotracers in a new model of osteonecrosis
OBJECTIVES: Conventional imaging methods are excellent for the morphological characterization of the consequences of osteonecrosis; however, only specialized techniques have been considered useful for obtaining functional information. To explore the affinity of radiotracers for severely devascularized bone, a new mouse model of isolated femur implanted in a
Clinics. Publicado em: 2016-10
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12. Biodistribution, pharmacokinetics and toxicity of a Vasconcellea cundinamarcensis proteinase fraction with pharmacological activity
Abstract Prior studies demonstrate that a proteinase fraction from Vasconcellea cundinamarcensis V.M. Badillo, Caricaceae, exhibits wound healing activity in gastric and cutaneous models and antitumoral/antimetastatic effects. Here, we present the toxicity, pharmacokinetics and biodistribution data for this proteinase fraction following a single dose into Sw
Rev. bras. farmacogn.. Publicado em: 2016-02