Binding
Mostrando 37-48 de 54928 artigos, teses e dissertações.
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37. Identification of Potential Inhibitors of Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Main Protease from Non-Natural and Natural Sources: A Molecular Docking Study
So far, there is neither a vaccine nor a specific antiviral drug to prevent or treat COVID-19 (coronavirus disease) infection. Recent studies have been done to investigate the capacity of human immunodeficiency virus type 1 (HIV-1) protease inhibitors be used in the treatment of COVID-19 patients. Some of those drugs have shown to be promising. Natural chemi
J. Braz. Chem. Soc.. Publicado em: 2020-12
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38. NO ESCAPE FROM CATEGORIZATION: AN INSIDER’S VIEW OF COMPOUNDS
Abstract There has been a surge of syntactic research on compounding, joining a large literature on the nature of roots and phase theory. In an attempt to probe into the syntactic domain for idiosyncratic interpretation and to account for categorial exocentricity, disappearance of subcategorization, and lexical integrity effects, some recent studies on compo
Ilha Desterro. Publicado em: 2020-12
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39. Synthesis, Characterization, Spectroelectrochemical, Photophysical and HSA-Binding Properties of Novel and Versatile meso-Tetra(4-pyridylvinylphenyl)porphyrins Coordinated to Ruthenium(II)-Polypyridyl Derivatives
The free-base meso-tetra(4-pyridylvinylphenyl)porphyrin (1a) and its zinc(II) complex were synthesized and then functionalized with [Ru(bpy)2Cl]+ units (2a and 2b) via conventional methods and evaluated in terms of photophysical, electrochemical and biological aspects. All porphyrins present moderate singlet oxygen production and fluorescence quantum yield,
J. Braz. Chem. Soc.. Publicado em: 2020-11
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40. COVID-19 - Endothelial Axis and Coronary Artery Bypass Graft Patency: a Target for Therapeutic Intervention?
Abstract It has been reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces endothelial inflammation, therefore facilitating the progression of endothelial and vascular dysfunction in coronavirus disease 2019 (COVID-19) patients. Coronary artery bypass grafting (CABG) involves mainly the use of the saphenous vein (SV) an
Braz. J. Cardiovasc. Surg.. Publicado em: 2020-10
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41. A Highly Selective Fluorescent Chemosensor for Al3+ Based on 2,2’:6’,2”-Terpyridine with a Salicylal Schiff Base
Two 2,2’:6’,2”-terpyridine-based Schiff bases (TPySSB and TPySB) have been synthesized. The TPySSB shows remarkable selective ‘off-on’ fluorescence for Al3+ in combination with photoinduced electron transfer (PET) mechanism and C=N isomerization mechanism. Chemosensor TPySSB binds Al3+ in a 1:2 ratio with an association constant 6.8 × 105 (correla
J. Braz. Chem. Soc.. Publicado em: 2020-09
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42. Calcium oxalate content from two Amazonian amilaceous roots and the functional properties of their isolated starches
Abstract The calcium oxalate content from two Amazonian amilaceous roots, Xanthosoma sagittifolium and Pachyrhizus tuberosus, before and after cooking were studied in the present work. Calcium oxalate raphides were observed by light microscopy in longitudinal sections from fresh tubers. The functional properties and physicochemical characteristics of isolate
Food Sci. Technol. Publicado em: 2020-09
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43. Chemical and Spectroscopic Characteristics of Anthrosol (Amazonian Dark Earth) and Surrounding Soil from the Brazilian Amazon Forest: Evaluation of Mineral and Organic Matter Content by Depth
The chemical and spectroscopic characteristics of soil organic matter (SOM) isolated from Amazonian dark earth (ADE) and surrounding soil (SR) were evaluated according to the soil depth. The results showed opposite trends for the soils. While ADE featured SOM with a greater aromatic condensation degree and greater hydrophobicity in the top layer, the SR show
J. Braz. Chem. Soc.. Publicado em: 2020-08
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44. Ischemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium,
Abstract Background Telogen effluvium is the most common form of non-scarring alopecia characterized by diffuse hair loss. Ischemia-modified albumin is a marker of oxidative stress and inflammation. Objective The aim of this study was to compare the levels of ischemia-modified albumin of telogen effluvium patients with healthy controls. Methods Ninety-one
An. Bras. Dermatol.. Publicado em: 2020-08
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45. Cardiovascular involvement in COVID-19: not to be missed
Abstract In December 2019, a striking appearance of new cases of viral pneumonia in Wuhan led to the detection of a novel coronavirus (SARS-CoV2). By analyzing patients with severe manifestations, it became apparent that 20 to 35% of patients who died had preexisting cardiovascular disease. This finding warrants the important need to discuss the influence of
Braz. J. Cardiovasc. Surg.. Publicado em: 2020-08
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46. Polimorfismo do gene da lectina ligante de manose e seu efeito em desfechos de curto prazo em bebês prematuros
Resumo Objetivo: A lectina ligante de manose (MBL, do inglês mannose-binding lectin), que pertence à família das colectinas, é um reagente de fase aguda que ativa o sistema complemento. Este estudo teve como objetivo investigar o efeito do polimorfismo do gene MBL2 em desfechos de curto prazo em prematuros. Método: Este estudo prospectivo incluiu cria
J. Pediatr. (Rio J.). Publicado em: 2020-08
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47. CHARACTERIZATION OF INTERACTION BETWEEN BUDDLEOSIDE AND BOVINE SERUM ALBUMIN
The primary objective of this study was to investigate the binding of buddleoside to bovine serum albumin (BSA) by different analytical techniques. The analytical principles of affinity capillary electrophoresis (ACE) and fluorescence spectroscopy used in the experiments were different. Mobility (M) that is independent of viscosity of the operating buffer an
Quím. Nova. Publicado em: 20/07/2020
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48. Synthesis, Characterization and in vitro, in vivo and in silico Anti-Inflammatory Studies of the Novel Hybrid Based on Ibuprofen and 3-Hydroxy-Copalic Acid Isolated from Copaiba Oil (Copaifera multijuga)
A novel anti-inflammatory hybrid 3-ibuprofenyl-copalic acid (3-IbuCA) was synthesized from 3-hydroxy-copalic acid isolated from Amazonian copaiba oil (Copaifera multijuga Hayne), and the anti-inflammatory ibuprofen. After full characterization, several assays to verify its anti-inflammatory effects were performed in vitro, in vivo and in silico (molecular do
J. Braz. Chem. Soc.. Publicado em: 2020-07