Bewo Cell
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Ação de antibióticos macrolídeos (azitromicina e espiramicina) sobre o perfil de produção de citocinas em linhagem de células tro-foblásticas BeWo e mielomonocíticas THP-1 infectadas por Toxoplasma gondii
Toxoplasma gondii é um parasito intracelular obrigatório capaz de infectar uma variedade de hospedeiros, causando infecções graves em indivíduos imunocomprometidos e em mulheres durante a gestação. Os antibióticos macrolídeos, azitromicina e espiramicina, têm efeitos comprovados no controle da toxoplasmose. Células trofoblásticas da linhagem BeWo
Publicado em: 2011
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2. Susceptibilidade diferencial de células trofoblásticas humanas (BeWo) e cervicais uterinas (HeLa) à infecção por Neospora caninum
Neospora caninum is an obligate intracellular parasite, closely related to Toxoplasma gondii, and considered a major cause of abortion and congenital neosporosis in cattle worldwide. As trophoblast cells act in mechanisms of innate immune defense at fetal-maternal interface, and no data are available about the interaction of this parasite with human trophobl
Publicado em: 2010
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3. Apoptose e proliferação celular em células trofoblásticas (linhagem BeWo) são diferentemente moduladas pelas cepas de Toxoplasma gondii
Transplacental transmission causes one of the most severe forms of infection with protozoan parasite Toxoplasma gondii. The ability of the parasite to survive intracellularly largely depends on the blocking of different proapoptotic signaling cascade of its host cell. However, alterations in the incidence of apoptosis, during pregnancy, are associated with a
Publicado em: 2009
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4. Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells
The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.
American Society for Microbiology.
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5. Characterization of the human c-fms gene product and its expression in cells of the monocyte-macrophage lineage.
The McDonough strain of feline sarcoma virus contains an oncogene called v-fms whose ultimate protein product (gp140v-fms) resembles a cell surface growth factor receptor. To identify and characterize the protein product of the proto-oncogene c-fms, antisera were prepared to the viral fms sequences and used to detect specific cross-reacting sequences in huma
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6. Characterization of transforming growth factor-beta (TGF-beta) receptors on BeWo choriocarcinoma cells including the identification of a novel 38-kDa TGF-beta binding glycoprotein.
Transforming growth factor-beta (TGF-beta) is a potential mediator of placental trophoblast functions, including differentiation, hormone production, endometrial invasion, and immunosuppression. Equilibrium binding and affinity-labeling assays were used to investigate the binding characteristics of TGF-beta 1 and TGF-beta 2 on an established human choriocarc
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7. Cell-to-Cell Contact Results in a Selective Translocation of Maternal Human Immunodeficiency Virus Type 1 Quasispecies across a Trophoblastic Barrier by both Transcytosis and Infection
Mother-to-child transmission can occur in utero, mainly intrapartum and postpartum in case of breastfeeding. In utero transmission is highly restricted and results in selection of viral variant from the mother to the child. We have developed an in vitro system that mimics the interaction between viruses, infected cells present in maternal blood, and the trop
American Society for Microbiology.
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8. Human transformed trophoblast-derived cells lacking CD4 receptor exhibit restricted permissiveness for human immunodeficiency virus type 1.
We investigated the nature of interaction of the malignantly transformed cell lines of trophoblast origin BeWo, JAR, and JEG-3 with three different human immunodeficiency virus type 1 (HIV-1) isolates (RF, 3B, and NDK). After inoculation with cell-free virus, the persistence of infection was determined for 1 month by monitoring the presence of viral DNA in t
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9. Human trophoblast cell-surface antigens defined by monoclonal antibodies.
A series of monoclonal antibodies has been raised against the human choriocarcinoma cell-line, BeWo. Four antigens, Trop-1, -2, -3, and -4, are defined on normal and malignant trophoblast cells. Trop-1 and Trop-2 appear to be specifically expressed on syncytio- and cytotrophoblasts, whereas Trop-3 and Trop-4 are also detected on various tumor cell lines, nor
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10. Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.
Human keratin 18 (K18) and the homologous mouse protein, Endo B, are intermediate filament subunits of the type I keratin class. Both are expressed in many simple epithelial cell types including trophoblasts, the first differentiated cell type to appear during mouse embryogenesis. The K18 gene was identified and cloned from among the 15 to 20 similar sequenc
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11. Expression of a fms-related oncogene in carcinogen-induced neoplastic epithelial cells.
Following carcinogen exposure in vitro, normal rat tracheal epithelial cells are transformed in a multistage process in which the cultured cells become immortal and, ultimately, neoplastic. Five cell lines derived from tumors produced by neoplastically transformed rat tracheal epithelial cells were examined for the expression of 11 cellular oncogenes previou
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12. Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody.
A radioimmunoassay was developed to directly assay the presence of transferrin receptors in human tissues. Antisera developed in a goat against purified human placental transferrin binding protein was purified by fractional sodium sulfate precipitation and adsorption against Sepharose-bound transferrin to remove trace anti-transferrin activity. The antisera