Beta Globin
Mostrando 1-12 de 961 artigos, teses e dissertações.
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1. Assessment of serum endocan levels in patients with beta-thalassemia minor
SUMMARY OBJECTIVE: Beta-thalassemia minor is a blood disease caused by a hereditary decrease in beta-globin synthesis, frequently leading to hypochromic microcytic anemia. Formerly called endothelial cell-specific molecule 1, endocan is a proteoglycan released by vascular endothelial cells in many organs. Our aim was to investigate the relationship between
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence
OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was ver
Clinics. Publicado em: 18/10/2018
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3. Presence of atypical beta globin (HBB) gene cluster haplotypes in sickle cell anemia patients of India
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-06
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4. The effects of old and recent migration waves in the distribution of HBB*S globin gene haplotypes
Abstract Sickle cell hemoglobin is the result of a mutation at the sixth amino acid position of the beta (β) globin chain. The HBB*S gene is in linkage disequilibrium with five main haplotypes in the β-globin-like gene cluster named according to their ethnic and geographic origins: Bantu (CAR), Benin (BEN), Senegal (SEN), Cameroon (CAM) and Arabian-Indian
Genet. Mol. Biol.. Publicado em: 03/10/2016
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5. Prevalence of βS-globin gene haplotypes, α-thalassemia (3.7 kb deletion) and redox status in patients with sickle cell anemia in the state of Paraná, Brazil
The aim of this study was to determine the frequency of beta S-globin gene (βS globin) haplotypes and alpha thalassemia with 3.7 kb deletion (−α3.7kb thalassemia) in the northwest region of Paraná state, and to investigate the oxidative and clinical-hematological profile of βS globin carriers in this population. Of the 77 samples analyzed, 17 were Hb S
Genet. Mol. Biol.. Publicado em: 21/08/2015
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6. Investigating alpha-globin structural variants: a retrospective review of 135,000 Brazilian individuals
Background: Brazil has a multiethnic population with a high diversity of hemoglobinopathies. While screenings for beta-globin mutations are far more common, alterations affecting alpha-globin genes are usually more silent and less well known. The aim of this study was to describe the results of a screening program for alpha-globin gene mutations in a repres
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-04
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7. Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis
This review discusses hemoglobin D-Punjab, also known as hemoglobin D-Los Angeles, one of the most common hemoglobin variants worldwide. It is derived from a point mutation in the beta-globin gene (HBB: c.364G>C; rs33946267) prevalent in the Punjab region, North-western Indian. Hemoglobin D-Punjab can be inherited in heterozygosis with hemoglobin A causing n
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-04
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8. HPV infection, risk factors and viral load among Mexican male college students
Objectives: To determine the prevalence of HPV and the risky sexual behaviors associated to it in a sample of male college students, taking into account genotype and viral load. Methods: From 2002 to 2003, male students from the Autonomous University of Morelos State completed a questionnaire and provided self-collected genital samples to detect and quant
Braz J Infect Dis. Publicado em: 2014-01
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9. Sickle cell anemia: clinical diversity and beta S-globin haplotypes
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013-06
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10. Beta-S globin haplotypes in patients with sickle cell anemia: one approach to understand the diversity in Brazil
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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11. Frequency and origin of haplotypes associated with the beta-globin gene cluster in individuals with trait and sickle cell anemia in the Atlantic and Pacific coastal regions of Colombia
Sickle cell anemia is a genetic disease with high prevalence in people of African descent. There are five typical haplotypes associated with this disease and the haplotypes associated with the beta-globin gene cluster have been used to establish the origin of African-descendant people in America. In this work, we determined the frequency and the origin of ha
Genet. Mol. Biol.. Publicado em: 2013
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12. Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. OBJECTIVE: To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012