Bactericidal Antibody
Mostrando 13-24 de 318 artigos, teses e dissertações.
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13. Evaluation of Streptococcus pneumoniae Type XIV Opsonins by Phagocytosis-Associated Chemiluminescence and a Bactericidal Assay
The relative roles of serum factors required for opsonization of type XIV Streptococcus pneumoniae were investigated by means of luminol-enhanced chemiluminescence (CL), bactericidal, and immunofluorescence assays employing adult sera containing high (>1,000 ng of antibody nitrogen per ml) or low (<200 ng of antibody nitrogen per ml) antibody concentrations
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14. A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.
A mouse immunoglobulin G3 monoclonal antibody specific for the core oligosaccharide moiety of the lipooligosaccharide (LOS) of Bordetella pertussis has been shown to have complement-dependent bactericidal activity. This monoclonal antibody exhibits bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition this monocl
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15. Comparison of the microagglutination test with bactericidal response to Legionella pneumophila (Legionnaires disease bacterium).
This investigation found that individuals with microagglutination antibody titers of 1:32 or greater to Legionella pneumophila produced bactericidal activity against the bacterium. Those individuals with microagglutination antibody titers of 1:16 or less demonstrated no bactericidal activity.
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16. Safety and immunogenicity of a group 29E meningococcal capsular polysaccharide vaccine in adults.
A serogroup 29E Neisseria meningitidis capsular polysaccharide vaccine at a dose of 50 micrograms was injected subcutaneously into 10 adult human volunteers. One vaccinate experienced a mild systemic reaction; one complained of moderate to severe local pain and tenderness. The vaccine induced significant homologous binding and bactericidal antibody by 2 week
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17. Reversal of the Bactericidal Reaction of Serum by Magnesium Ion
Muschel, Louis H. (University of Minnesota, Minneapolis), and Jean E. Jackson. Reversal of the bactericidal reaction of serum by magnesium ion. J. Bacteriol. 91:1399–1402. 1966.—Magnesium ion was found to reverse the bactericidal action of the antibody-complement system. Concentrations of 0.03 to 0.11 m MgSO4 or MgCl2 were effective, provided that the re
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18. Deficient Serum Bactericidal Activity Against Escherichia Coli in Patients with Cirrhosis of the Liver
The serum bactericidal activity (SBA) of cirrhotic patients was compared with that of normal individuals using the release of 51Cr from radiolabeled Escherichia coli as the assay method. 80% (22/27) of patients were found to have deficient SBA against at least one of three smooth, serum-sensitive test strains of E. coli. Cirrhotic patients were found to have
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19. Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody.
A 16,600-D outer membrane protein is present in all strains of Haemophilus influenzae and antibodies to this protein are present in human serum. This study was designed to assess the role of this outer membrane protein (P6) in nontypeable H. influenzae as a target for human serum bactericidal antibody. P6 was isolated and coupled to an affinity column. Deple
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20. New Classification of Neisseria meningitidis by Means of Bactericidal Reactions
A bactericidal assay is described which allows identification of distinct serotypes within a serogroup of Neisseria meningitidis. Antisera produced in rabbits against seven group C strains by two intravenous inoculations of live organisms were found to contain two types of bactericidal antibodies. One, directed against the group-specific polysaccharide, caus
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21. Characterization of the physiological requirements for the bactericidal effects of a monoclonal antibody to OspB of Borrelia burgdorferi by confocal microscopy.
A confocal microscopy study was undertaken to characterize the bactericidal effects of the Fab fragments of CB2, an immunoglobulin G1kappa murine monoclonal antibody, to an epitope in the carboxy region of the outer surface protein B (OspB) of Borrelia burgdorferi. Simultaneous direct labeling of both fixed and live spirochetes with fluorochrome-labeled Fab-
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22. BACTERICIDAL METHOD FOR THE MEASUREMENT IN NORMAL SERUM OF ANTIBODY TO GRAM-NEGATIVE BACTERIA
Landy, Maurice (National Cancer Institute, Bethesda, Md.), J. Gabriel Michael, and James L. Whitby. Bactericidal method for the measurement in normal serum of antibody to gram-negative bacteria. J. Bacteriol. 83:631–640. 1962.—The bactericidal effect of normal serum on gram-negative bacteria was investigated with the objective of determining whether this
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23. Nonabsorbable Rabbit Anti-Salmonella typhimurium Antibody as Detected by the Complement-Mediated Bactericidal Reaction
Herzberg, Mendel (University of Florida, Gainesville), Kathryn V. Kenny, and John B. Robbins. Nonabsorbable rabbit anti-Salmonella typhimurium antibody as detected by the complement-mediated bactericidal reaction. J. Bacteriol. 91:1548–1555. 1966.—A portion of antibody active in the complement-mediated bactericidal reaction against Salmonella typhimurium
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24. A Modified Enzyme-Linked Immunosorbent Assay for Measurement of Antibody Responses to Meningococcal C Polysaccharide That Correlate with Bactericidal Responses
The standardized enzyme-linked immunosorbent assay (ELISA) for measurement of serum immunoglobulin G (IgG) antibody responses to meningococcal C polysaccharide has been modified to employ assay conditions that ensure specificity and favor detection primarily of high-avidity antibodies. The modified and standard assays were used to measure IgG antibody concen
American Society for Microbiology.