Baclofen
Mostrando 13-24 de 130 artigos, teses e dissertações.
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13. Effect of the GABA B agonist baclofen on dipyrone-induced delayed gastric emptying in rats
Dipyrone administered intravenously (iv) or intracerebroventricularly (icv) delays gastric emptying (GE) in rats. Gamma-aminobutyric acid (GABA) is the most potent inhibitory neurotransmitter of the central nervous system. The objective of the present study was to determine the effect of icv baclofen, a GABA B receptor agonist, on delayed GE induced by dipyr
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-01
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14. Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both alpha2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nerv
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-10
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15. A new approach to the synthesis of (±)-methyl jasmonate and (±)-baclofen via conjugated addition of oxazoline cyanocuprate to Michael acceptors
A introdução de um grupamento equivalente ao ânion carboximetil a enonas e nitroalquenos através da reação de adição 1,4 do cianocuprato da 2,4,4-trimetil-2-oxazolina 3, resulta numa metodologia interessante para a síntese de produtos naturais como (±)-metil jasmonato (1) e (±)-baclofen (2).
Journal of the Brazilian Chemical Society. Publicado em: 2001-10
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16. Reações de Heck da N-Boc-3-pirrolina com sais de diazonio. Aplicações na sintese de arilcainatos, arilaspartatos, lactamas ariladas e do baclofeno e analogos
Heck Reaction of N-Boc-3-pyrroline with aryldiazonium salts reemerged as a very practical alternative to the "traditional" Heck protocols, which use mostly aryl triflates or aryl halides. The lactamols obtained in the Heck reaction were employed with success at the synthesis of important pharmacologically active compounds. The dehydration of the lactamols pr
Publicado em: 2001
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17. Estudos visando a sintese de derivados do acido 4-amino-3- (4clorofenil) butirico (BACLOFEN) / Studies towards the synthesis of derived of the 4-amine-3- (4chlorophenyl) butryric acid (BACLOFEN)
O ácido g-aminobutírico (GABA) é o mais importante neurotransmissor inibitório presente no Sistema Nervoso Central. Ele sozinho é responsável por 34% de todas as sinapses que ocorrem no cérebro. A ação do GABA no SNC é realizada através da interação com dois tipos diferentes de receptores, classificados por Hill e Bowery como GABAA e GABAB. Esse
Publicado em: 2000
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18. On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones.
1. (-)Baclofen reduces inhibitory postsynaptic potentials (IPSPs) and the associated synaptic currents (IPSCs) at inhibitory GABAergic synapses between cultured rat hippocampal neurones. The reversal potential for the IPSC is unaltered. 2. The effect of (-)baclofen is concentration dependent; the EC50 for (-)baclofen is approximately 5 microM. 3. Statistical
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19. Comparison of the action of baclofen with gamma-aminobutyric acid on rat hippocampal pyramidal cells in vitro.
Intracellular recordings from CA1 pyramidal cells in the hippocampal slice preparation were used to compare the action of baclofen, a gamma-aminobutyric acid (GABA) analogue, with GABA. Ionophoretic application of GABA or baclofen into stratum (s.) pyramidale evoked hyperpolarizations associated with reductions in the input resistance of the cell. Baclofen r
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20. Lasting reduction of severe spasticity after ending chronic treatment with intrathecal baclofen.
OBJECTIVE--To investigate whether the dose of intrathecal baclofen necessary for a sufficient reduction of muscle tone and spasms changes during treatment of severe spasticity. METHODS--A group of 27 patients received intrathecal baclofen for 61 (SD 18) months. RESULTS--Spasticity remained absent or strongly reduced after stopping the intrathecal baclofen in
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21. Assessment of Feasibility of Maillard Reaction between Baclofen and Lactose by Liquid Chromatography and Tandem Mass Spectrometry, Application to Pre Formulation Studies
The aim of this study was to determine any possible, baclofen–lactose Maillard reaction products. Granules and tablets of baclofen and lactose were prepared and maintained in heat ovens for a certain time period. The effects of lactose type, addition of magnesium stearate, and water were monitored. Heated lactose and baclofen were analyzed using reverse-ph
Springer US.
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22. Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action.
1. Intracellular recordings were obtained from neurones in layers 2 and 3 of the rat frontal neocortex in an in vitro slice preparation. Three distinct types of stimulation-evoked post-synaptic potentials were recorded in these neurones: excitatory post-synaptic potentials (e.p.s.p.s); bicuculline-sensitive, chloride-dependent inhibitory post-synaptic potent
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23. On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
1. Intracellular recordings were made from 193 substantia nigra zona compacta neurones in slices of rat mesencephalon. All cells were hyperpolarized by baclofen; this was accompanied by a fall in input resistance. Cells voltage clamped at -60 mV showed an outward current associated with a conductance increase in response to baclofen. The baclofen effects wer
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24. Comparison of the actions of baclofen at pre- and postsynaptic receptors in the rat hippocampus in vitro.
1. Intracellular microelectrode recordings were used to study the cellular location, pharmacology, and mechanism of action of gamma-aminobutyric acidB (GABAB) receptors on pyramidal cells and presynaptic axonal endings in area CA3 of organotypic hippocampal slice cultures. 2. Baclofen (bath applied at 10 microM) caused a 10-15 mV hyperpolarization of CA3 cel