Azoxymethane
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. MORPHOLOGICAL CHARACTERIZATION OF COLORECTAL PITS USING AUTOFLUORESCENCE MICROSCOPY IMAGES
RESUMO CONTEXTO: O câncer colorretal é uma das patologias mais prevalentes. Seu prognóstico é ligado à detenção e ao tratamento precoces. Atualmente o diagnóstico é realizado por análise histológica de biópsias de pólipo, seguida de classificação morfológica. A classificação de padrões de Kudo é frequentemente utilizada para a diferenci
Arq. Gastroenterol.. Publicado em: 26/08/2019
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2. Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane
Abstract Purpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups re
Acta Cir. Bras.. Publicado em: 28/02/2019
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3. Synbiotic preparation with Lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci
Abstract Host microbiome and metabolome are associated with the incidence of colorectal cancer (CC), one of the major health problems in developed countries. The pro and prebiotic supplementation helps to improve the host health. Inulin is one such prebiotic used for the enhancement of naïve probiotic bacterial population. This paper explains the impact of
Food Sci. Technol. Publicado em: 29/05/2017
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4. Ponderal behavior of rats fed an omegas 3, 6 and 9 enriched diet submitted to colon carcinogenesis induced by azoxymethane
PURPOSE: To assess weight changes in rats fed diets with different ratios of omegas 3, 6 and 9 submitted to colonic carcinogenesis induced by Azoxymethane (AOM). METHODS: Sixty rats with three weeks of life were distributed into five groups of specific diets containing 12 animals each: GI- Standard diet without adminstration of AOM, GII- Standard diet with a
Acta Cir. Bras.. Publicado em: 2013-10
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5. Quantitative study of FAS ligand expression on gastric mucosa of rats submited to oxidative stress by Azoxymethane / Estudo quantitativo na expressão de FAS ligante pós indução de estresse oxidativo em mucosa gástrica com administração de azoximetano, em ratos
Objetivo: Estudar quantitativamente a expressão da proteína ativadora de apoptose FAS ligante (FAS-L) na mucosa gástrica de ratos submetidos à exposição ao Azoximetano (AOM). Métodos: Ratos Wistar (n=56) divididos em 2 grupos: G1, controle (n=28), e G2, AOM (n=28), recebendo injeções subcutâneas de solução salina (1 mL/Kg) ou AOM (5 mg/Kg), respe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/11/2011
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6. Efeito da dieta hipercalÃrica e hiperlipÃdica na formaÃÃo de criptas aberrantes induzidas por azoximetano em mucosa cÃlica de ratos / Effect of a hypercaloric and hyperlipidic diet, rich in polyunsaturated fat, ω-3 and ω-9, aberrant crypt on formation in colonic mucosa, azoxymethane-induced in rats
O cÃncer colorretal (CCR) à a quinta neoplasia mais incidente no Brasil e sua freqÃÃncia vem aumentando em paÃses industrializados. A lesÃo prÃ-neoplÃsica mais precoce com presenÃa de displasia à o foco de cripta aberrante (FCA), estando relacionada como lesÃo precursora de adenomas colorretais e cÃncer em humanos. O entendimento destas lesÃes �
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/11/2008
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7. Propriedades imunestimulatorias e antitumoral de concentrados proteicos de soro de leite bovino, de caseina e de um isolado proteico de soja. / Antitumoral and imunostimulating properties of bovine milk whey proteics concentrates, of casein and a soy protein isolated.
The objective of the present work was the investigation of immunomodulation and anticancer properties presented by bovine milk proteins with special attention to the whey proteins, in the form of whey protein concentrate (WPC). For such a task, adequate methodology was established for the production of concentrates of caseins and whey proteins, which permitt
Publicado em: 2004
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8. Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation
Aldose reductase (AR; EC 1.1.1.21), an nicotinamide adenine dinucleotide phosphate-dependent aldo–keto reductase, has been shown to be involved in oxidative stress signaling initiated by inflammatory cytokines, chemokines and growth factors. Recently, we have shown that inhibition of this enzyme prevents the growth of colon cancer cells in vitro as well as
Oxford University Press.
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9. APC-dependent suppression of colon carcinogenesis by PPARγ
Activation of PPARγ by synthetic ligands, such as thiazolidinediones, stimulates adipogenesis and improves insulin sensitivity. Although thiazolidinediones represent a major therapy for type 2 diabetes, conflicting studies showing that these agents can increase or decrease colonic tumors in mice have raised concerns about the role of PPARγ in colon cancer.
The National Academy of Sciences.
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10. Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation
Liver receptor homolog 1 (LRH-1) is an orphan nuclear receptor that synergizes with β-catenin/T cell factor 4 signaling to stimulate intestinal crypt cell renewal. We evaluated here the impact of haploinsufficiency of LRH-1 on intestinal tumorigenesis by using two independent mouse models of human colon tumorigenesis. Haploinsufficiency of LRH-1 blunts inte
National Academy of Sciences.
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11. Targeted Genetic Disruption of Peroxisome Proliferator–Activated Receptor-δ and Colonic Tumorigenesis
Peroxisome proliferator–activated receptor-delta (PPAR-δ) is overexpressed in human colon cancer, but its contribution to colonic tumorigenesis is controversial. We generated a mouse model in which PPAR-δ was genetically disrupted in colonic epithelial cells by targeted deletion of exon 4. Elimination of colon-specific PPAR-δ expression was confirmed by
Oxford University Press.
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12. Feeding of soy protein isolate to rats during pregnancy and lactation suppresses formation of aberrant crypt foci in their progeny's colons: interaction of diet with fetal alcohol exposure
Soy protein isolate (SPI) in the diet may inhibit colon tumorigenesis. We examined azoxymethane (AOM)-induced aberrant crypt foci (ACF) in male rats in relation to lifetime, pre-weaning, or post-weaning dietary exposure to SPI and also within the context of fetal alcohol exposure. Pregnant Sprague Dawley rats were fed AIN-93G diets containing casein (20%, th
BioMed Central.