Azoles
Mostrando 13-24 de 173 artigos, teses e dissertações.
-
13. Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species
The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the activity of azoles. The objective of this study was to identify mutations in the coding region of theERG1
Mem. Inst. Oswaldo Cruz. Publicado em: 15/03/2016
-
14. Antifungal Susceptibility In Vitro Determined by the Etest(r) for Candida Obtained from the Oral Cavity of Irradiated and Elderly Individuals
Esse estudo objetivou avaliar a susceptibilidade antifúngica in vitro de espécies de Candida obtidas de pacientes irradiados em cabeça e pescoço (Grupo 1), idosos não institucionalizados (Grupo 2) e idosos institucionalizados (Grupo 3) usando a metodologia Etest(r). Candida foi isolada da saliva e identificada presuntivamente pelo teste CHROMagar Candid
Braz. Dent. J.. Publicado em: 2015-04
-
15. Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of
Braz. J. Microbiol.. Publicado em: 31/03/2015
-
16. Hologram- and descriptor-based QSAR studies for a series of non-azoles derivatives active against C. neoformans
Durante as últimas décadas as infecções fúngicas têm se tornado um crescente problema de saúde, especialmente para pacientes imunocomprometidos. Infelizmente, o padrão-ouro de terapia profilática para tal doença é baseada em derivados azólicos, que são mais fungistáticos do que fungicidas contra C. neoformans e causam hepatotoxicidade. Objetiva
J. Braz. Chem. Soc.. Publicado em: 2013-10
-
17. Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, vorico
Braz J Infect Dis. Publicado em: 2013-08
-
18. Terbinafine inhibits Cryptococcus neoformans growth and modulates fungal morphology
Cryptococcus neoformans is an encapsulated fungus that causes cryptococcosis. Central nervous system infection is the most common clinical presentation followed by pulmonary, skin and eye manifestations. Cryptococcosis is primarily treated with amphotericin B (AMB), fluconazole (FLC) and itraconazole (ITC). In the present work, we evaluated the in vitro effe
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-08
-
19. The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates
The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-05
-
20. Susceptibility tests of oropharyngeal Candida albicans from Egyptian patients to fluconazole determined by three methods
Candida albicans frequently cause oropharyngeal candidiasis in immunocompromised patients. As some of these isolates show resistance against azoles, the clinician is wary of initiating therapy with fluconazole (FZ) until a final susceptibility report is generated. We aimed to evaluate the efficacy of rapid flow cytometry (FCM) and disc diffusion (DD) methods
Brazilian Journal of Microbiology. Publicado em: 2012-03
-
21. Estudos de QSAR 2D baseados em descritores topológicos e fragmentos moleculares para uma série de derivados azólicos ativos contra Candida albicans
Azole derivatives are the main therapeutical resource against Candida albicans infection in immunocompromised patients. Nevertheless, the widespread use of azoles has led to reduced effectiveness and selection of resistant strains. In order to guide the development of novel antifungal drugs, 2D-QSAR models based on topological descriptors or molecular fragme
Química Nova. Publicado em: 2012
-
22. ResistÃncia a azÃlicos em candida spp. de origem veterinÃria: um fenÃmeno mediado por bombas de efluxo / AZOLE RESISTANCE IN CANDIDA SPP. FROM VETERINARY SOURCES: AN EFFLUX-MEDIATED PHENOMENON
O monitoramento da sensibilidade antifÃngica em espÃcies de Candida de origem veterinÃria à uma prÃtica recente e os mecanismos envolvidos ainda nÃo foram completamente elucidados. Considerando que o arsenal de drogas antifÃngicas à limitado e que o fenÃmeno de resistÃncia tem se tornado mais freqÃente, a compreensÃo deste fenÃmeno e a busca por
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
-
23. Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis
Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves t
Revista Brasileira de Farmacognosia. Publicado em: 12/08/2011
-
24. Fatores de virulência e suscetibilidade a drogas antifíngicas de cepas clínicas e ambientais de Cryptococus spp.
The cryptococcosis is a systemic mycosis, which the meningoencephalitis is the most severe and most common clinical manifestation. The main species involved in your etiology are Cryptococcus neoformans and Cryptococcus gattii. The ecology of these species is not well, known, C. neoformans has the excrement of birds, mainly pigeons, as its principal habitat a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/03/2009