Axotomy
Mostrando 13-24 de 79 artigos, teses e dissertações.
-
13. Microtubule destabilization and neurofilament phosphorylation precede dendritic sprouting after close axotomy of lamprey central neurons.
Axotomy of giant lamprey (Petromyzon marinus) central neurons (anterior bulbar cells) close to their somata results in ectopic axon-like sprouting from the dendritic tips. Such sprouts first appear as swellings at the tips of a small subset of dendrites 2-3 weeks after "close" axotomy. We report here that immunocytochemical examination of these swellings rev
-
14. Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.
Sympathetic neurons in the superior cervical ganglion (SCG) of adult rats depend on target-derived nerve growth factor (NGF) for maintenance of tyrosine hydroxylase (TH) levels and the noradrenergic neurotransmitter system. Axotomy of a SCG results in NGF deprivation, causing a decline in TH activity; continuous local application of NGF can prevent this decl
-
15. Exogenous heat shock cognate protein Hsc70 prevents axotomy-induced death of spinal sensory neurons
Elevation of intracellular heat shock protein (Hsp)70 increases resistance of cells to many physical and metabolic insults. We tested the hypothesis that treatment with Hsc70 can also produce that effect, using the model of axotomy-induced neuronal death in the neonatal mouse. The sciatic nerve was sectioned and in some animals purified bovine brain Hsc70 wa
Cell Stress Society International.
-
16. Electrophysiological properties of axotomized facial motoneurones that are destined to die in neonatal rats.
1. Rat facial motoneurones axotomized on the day after birth were examined morphologically, and their electrical properties were characterized using the whole-cell recording technique in thin slices of the brainstem. 2. About 40% of facial motoneurones were lost within 4 days of axotomy, and only about 20% of the neurones survived 9 days after axotomy. 3. Th
-
17. Transient, axotomy-induced changes in the membrane properties of crayfish central neurones.
1. In crayfish, the normally passive, non-spiking somata of certain unipolar, efferent neurones became spiking within 36 hr of axotomy. 2. The changes persisted for approximately 2 weeks and then waned. The decline in excitability occurred independently of regeneration, and excitability was not restored by recutting the axon stump. 3. The neuropilar processe
-
18. Changes in potassium channel activity following axotomy of B-cells in bullfrog sympathetic ganglion.
1. Whole-cell and microelectrode voltage-clamp techniques were used to investigate the changes in ionic currents and action potential shape that follow axotomy of bullfrog paravertebral sympathetic ganglion B-cells. 2. Axotomy increased M-conductance (gM; muscarine-sensitive, voltage- and time-dependent K+ conductance) by 35% at -30 mV and slowed its deactiv
-
19. Long-Term Memory Survives Nerve Injury and the Subsequent Regeneration Process
A three-neuron network (a central pattern generator [CPG]) is both sufficient and necessary to generate aerial respiratory behavior in the pond snail, Lymnaea stagnalis. Aerial respiratory behavior is abolished following a specific nerve crush that results in axotomy to one of the three CPG neurons, RPeD1. Functional regeneration of the crushed neurite occur
Cold Spring Harbor Laboratory Press.
-
20. Electrophysiology of degenerating neurones in the vagal motor nucleus of the guinea-pig following axotomy.
1. The electrophysiological properties of motoneurones in the dorsal motor nucleus of the vagus in the guinea-pig were studied at different times following cervical vagotomy. The results were compared both to normal neurones and to results obtained at the same time from intact neurones located in the contralateral nucleus. 2. The input resistances of axotomi
-
21. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy
Spinal sensory (dorsal root ganglion; DRG) neurons display slowly inactivating, tetrodotoxin-resistant (TTX-R), and rapidly inactivating, TTX-sensitive (TTX-S) Na currents. Attenuation of the TTX-R Na current and enhancement of TTX-S Na current have been demonstrated in cutaneous afferent DRG neurons in the adult rat after axotomy and may underlie abnor
The National Academy of Sciences of the USA.
-
22. Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy.
Antisense (AS) oligonucleotides (ONs) to galanin (GAL) were applied to the proximal end of a transected sciatic nerve, allowing their cellular uptake and transport into injured axons. GAL expression in dorsal root ganglia and self-mutilation behavior (autotomy) were then studied. AS-ONs with phosphorothioate or allyl modifications significantly suppressed th
-
23. Membrane properties of primary sensory neurones of the cat after peripheral reinnervation.
1. The properties of sensory neurones in the petrosal ganglion of the cat were examined in vitro with intracellular electrodes 2-30 days after cutting the carotid or the glossopharyngeal nerve or 30-120 days after crushing the nerves and allowing time for peripheral reinnervation. Both glossopharyngeal and carotid neurones with conduction velocities faster t
-
24. The effects of axotomy on the conduction of action potentials in peripheral sensory and motor nerve fibres.
Medial gastrocnemius and sural nerves in one hindlimb of the cat were transected and prevented from regenerating. After periods ranging from 29-273 days, compound action potentials were recorded from axotomised and contralateral control nerves. The amplitude and integrated area of action potentials decreased and conduction velocity slowed following axotomy.