Atrial Heart Septal Defects
Mostrando 25-36 de 42 artigos, teses e dissertações.
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25. Bidirectional shunt in uncomplicated atrial septal defect.
The presence of right to left shunts at atrial level in 40 patients with an uncomplicated atrial septal defect was determined by measuring the pulmonary vein to systemic artery oxygen stepdown . In six patients (group 1) a sizeable right to left shunt was found: left atrial oxygen stepdown was greater than or equal to 0.7 vol%, mean right to left shunt 0.67
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26. A Biographical Sketch of Lewis Dexter
Dr. Lewis Dexter was an outstanding cardiovascular physiologist and clinician, a respected teacher and scientist, and, most importantly, a fine human being. During his life, he brought the cardiac catheter from the laboratory to the patient and trained several generations of cardiologists. Dexter's laboratory was the first to elucidate the pathophysiologic a
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27. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice.
Retinoid-dependent pathways play a central role in regulating cardiac morphogenesis. Recently, we characterized gene-targeted RXR alpha -/- embryos, which display an atrial-like ventricular phenotype with the development of heart failure and lethality at embryonic day 14.5. To quantitate the frequency and complexity of cardiac morphogenic defects, we now use
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28. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
Heterozygous mutations in NKX2.5, a homeobox transcription factor, were reported to cause secundum atrial septal defects and result in atrioventricular (AV) conduction block during postnatal life. To further characterize the role of NKX2.5 in cardiac morphogenesis, we sought additional mutations in groups of probands with cardiac anomalies and first-degree A
American Society for Clinical Investigation.
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29. Morphology and classification of atrioventricular defects.
Anatomical studies were made on 114 necropsy specimens of atrioventricular defects with atrioventricular concordance. The malformation is characterised by disproportion between the ventricular inlet and outlet dimensions and a malorientation of the aortic valve relative to the atrioventricular valve or valves. Associated with this there is a characteristic '
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30. Right-sided endocarditis involving both tricuspid and pulmonary valves in a patient with ventricular septal defect.
A patient with alpha-haemolytic streptococcus endocarditis on a ventricular septal defect is described. The disease spread to involve both tricuspid and pulmonary valves which were largely destroyed. The patient developed severe right heart failure with pronounced rise in right atrial pressure. This led to right-to-left shunting through the foramen ovale wit
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31. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.
We have recently characterized a cardiac model of ventricular chamber defects in retinoid X receptor alpha (RXR alpha) homozygous mutant (-/-) gene-targeted mice. These mice display generalized edema, ventricular chamber hypoplasia, and muscular septal defects, and they die at embryonic day 15. To substantiate our hypothesis that the embryos are dying of car
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32. Congenital cardiac abnormalities in monozygotic twins. Report and review of the literature.
A pair of monozygotic twin girls is reported with concordance for 3 congenital cardiac abnormalities: (1) secundum atrial septal defect, (2) aneurysm of the membraneous ventricular septum, and (3) electrocardiographic frontal plane left axis deviation. A review of the published materials shows a 9.5 per cent incidence of concordance for congenital heart dise
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33. Cardiac ultrasonography in structural abnormalities and arrhythmias. Recognition and treatment.
Fetal cardiac ultrasonography has become an important tool in the evaluation of fetuses at risk for cardiac anomalies. It can both guide prenatal treatment and assist the management and timing of delivery. We recommend that a fetal echocardiogram be done when there is a family history of congenital heart disease; maternal disease that may affect the fetus; a
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34. Unknown syndrome: abnormal facies, hypothyroidism, and severe retardation: a second patient.
In the November 1987 issue of this journal, Young and Simpson presented a female infant with abnormal facies (microcephaly, blepharophimosis, small, low set, posteriorly rotated ears, bulbous nose, carp shaped mouth, and micrognathia), congenital heart abnormalities (large atrial and ventricular septal defects), congenital hypothyroidism, and severe global r
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35. Influence of colour Doppler echocardiography on the ultrasonic assessment of congenital heart disease: a prospective study.
OBJECTIVE--To evaluate the additional information provided by colour Doppler in the ultrasonic assessment of congenital heart disease. PATIENTS AND METHODS--A prospective study of 215 children (age range 1 day-16 years) presenting with clinical signs of congenital heart disease. RESULTS--Colour Doppler was essential for the diagnosis of an anomalous left cor
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36. Morphological study of defects of the atrial septum within the oval fossa: implications for transcatheter closure of left-to-right shunt.
OBJECTIVE--To determine the anatomical variability of the oval fossa in cases of atrial septal defect and to find out which factors might make such defects suitable or unsuitable for closure by umbrella or clamshell devices. DESIGN--100 specimens with defects of the atrial septum within the oval fossa were studied, especially the position of the defects with