Atp Dependent Potassium Channels
Mostrando 1-12 de 72 artigos, teses e dissertações.
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1. Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rats
Clobenzorex is a metabolic precursor of amphetamine indicated for the treatment of obesity. Amphetamines have been involved with cardiovascular side effects such as hypertension and pulmonary arterial hypertension. The aim of the present study was to investigate whether the direct application of 10–9–10–5 M clobenzorex on isolated phenylephrine-precont
Braz J Med Biol Res. Publicado em: 07/08/2017
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2. Ação do inibidor da enzima dipeptidil peptidase 4 sobre o pré-condicionamento isquêmico em pacientes portadores de diabetes mellitus tipo 2 e doença arterial coronariana estável / Effect of dipeptidyl peptidase-4 enzyme inhibitor on ischemic preconditioning in patients with type 2 diabetes and symptomatic coronary artery disease
Ischemic preconditioning (IPC) refers to the phenomenon in which short periods of myocardial ischemia and reperfusion promote resistance to a subsequent prolonged ischemic insult. Some hypoglycemic drugs, such as glibenclamide and repaglinide, are able to inhibit this protective phenomenon probably by its effects as blockers of adenosine triphosphate-depende
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/10/2012
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3. Effect of glibenclamide on antinociceptive effects of antidepressants of different classes
OBJECTIVES: The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a K ATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action. METHODS: Three antidepressant drugs, amitriptyline as a dual-action, nonselective inhibitor of noradrenaline an
Clinics. Publicado em: 2011
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4. Avaliação dos efeitos induzidos pelo 2-Nitrato-1, 3-Dibutoxipropano (NDBP) sobre o sistema cardiovascular de ratos normotensos - abordagens en vivo e in vitro
Organic nitrates are nitric oxide (NO) donors used in the treatment of cardiovascular diseases mimicking the role of endogenous NO. This study evaluated organic nitrates newly synthesized from glycerin, which cardiovascular actions had not yet been investigated. Therefore, the cardiovascular effects produced by organic nitrates derived from glycerin: 2-nitra
Publicado em: 2010
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5. Effect of a high fat diet on mitochondria: bioenergetics, K+ transport and redox state / Efeito de dietas hiperlipídicas sobre mitocôndrias de fígado de camundongos: bioenergética, transporte de K+ e estudo redox
Obesity is associated with multiple dysfunctions including dyslipidemia, insulin resistance and diabetes. These malfunctions are associated with modifications in mitochondrial physiology. Furthermore, mitochondria are the most important site of energy metabolism and reactive oxygen species production. Alberici et al. (2006) demonstrated that hypertriglycerid
Publicado em: 2009
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6. Characterization of genes and serum proteins related to type 2 diabetes mellitus in patients treated with pioglitazone / Caracterização de genes e proteínas plasmáticas relacionadas ao diabetes melito do tipo 2 em indivíduos tratados com pioglitazona
The diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, the result from insulin secretion or action deficiency, or both. Pioglitazone is an oral hypoglycemic drug, included in the class of thiazolidinediones, which work by binding to nuclear receptors PPARY nuclear what improve the state of resistance to insulin. Pioglitazone m
Publicado em: 2008
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7. IdentificaÃÃo dos mecanismos envolvidos no relaxamento da musculatura lisa cavernosa e da aorta de coelho, induzido por doadores de Ãxido nÃtrico do complexo nitrosil-rutÃnio / Identification of the involved mechanisms in the relaxation of the cavernous smooth musculatura and aorta of rabbit, induced for nitric oxide givers of the nitrosil-rutÃnio complex
Endothelial dysfunction makes 56% of patients with erectile dysfunction decline treatment with PDE-5 inhibitors. New forms of treatment are necessary for this group of patients. The present study evaluates the relaxation in vitro induced in rabbit corpus cavernosum smooth muscle and aortic rings by sodium nitroprusside (SNP) and by two new NO-donor substance
Publicado em: 2008
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8. Efeito Protetor Do LipopolissacarÃdeo Da Escherichia Coli Na LesÃo GÃstrica Por Indometacina Em Ratos - Envolvimento Da Cicloxigenase Do Tipo 2, Da No Sintase Induzida E Dos Canais De PotÃssio SensÃveis Ao ATP. / The protective effect of Escherichia coli lipopolysaccharide in gastric injury in indomethacin rats - Involvement of cyclooxygenase type 2 NO synthase induced potassium channels and ATP-sensitive.
INTRODUÃÃO: O papel do LPS na defesa da mucosa gÃstrica ainda nÃo està estabelecido. OBJETIVOS: 1-Verificar o efeito protetor do LPS na lesÃo gÃstrica (LG), na infiltraÃÃo de neutrÃfilos (IN), no aumento da adesÃo leucocitÃria, na diminuiÃÃo dos nÃveis de GSH induzidos por indometacina (INDO) em ratos; 2-Investigar o papel da COX-2, NOSi e dos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/06/2005
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9. Participação do oxido nitrico e do canal de potassio ATP-dependente na ereção peniana em cães / Role of adenosine triphosphate-dependent potassium chanels in canine penile erection
Objective: To define the physiologic role and hemodynamic features of nitric oxide (NO) and the adenosine triphosphate (ATP)-dependent K+ (KATP)channel in canine penile erection. Material and Methods: Mongrel dogs were anesthetized, and penile erection was induced by electrical stimulation of the pelvic nerve. Changes in the intracavemous pressure (ICP) were
Publicado em: 2005
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10. The mechanism of gentisic acid-induced relaxation of the guinea pig isolated trachea: the role of potassium channels and vasoactive intestinal peptide receptors
We examined some of the mechanisms by which the aspirin metabolite and the naturally occurring metabolite gentisic acid induced relaxation of the guinea pig trachea in vitro. In preparations with or without epithelium and contracted by histamine, gentisic acid caused concentration-dependent and reproducible relaxation, with mean EC50 values of 18 µM and Ema
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-03
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11. Bradykinin enhances membrane electrical activity of pancreatic beta cells in the presence of low glucose concentrations
In most of cells bradykinin (BK) induces intracellular calcium mobilization. In pancreatic beta cells intracellular calcium is a major signal for insulin secretion. In these cells, glucose metabolism yields intracellular ATP which blocks membrane potassium channels. The membrane depolarizes, voltage-dependent Ca2+ channels are activated and the intracellular
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-09
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12. Vasorelaxant effects of the potassium channel opener SR 47063 on the isolated human saphenous vein and rat aorta
The vasorelaxant effects of SR 47063 (4-(2-cyanimino-1,2-dihydropyrid-1-yl)-2,2-dimethyl-6-nitrochromene), a new K+-channel opener structurally related to levcromakalim, were examined in isolated human saphenous vein (HSV) and rat aorta (RA). HSV or RA rings were precontracted with either KCl or noradrenaline and cumulative relaxant concentration-response cu
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-08